Results 161 to 170 of about 1,062,531 (360)
Advanced Science, EarlyView.Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang +12 more
wiley +1 more source
مجله دانشگاه علوم پزشکی گرگان, 2017 Background and Objective: General anxiety disorder is one of the chronic disorders in the general population and population with clinical symptoms. This study was conducted to evaluate the efficacy of combined treatment based on acceptance and commitment
Majid Mahmoud Alilou +2 more
doaj
Light Therapy Alleviates Addiction‐Related Symptoms and Reshapes Habenula and Midbrain Pathways
Advanced Science, EarlyView.This study investigates light therapy for treating Internet Gaming Disorder (IGD). Functional MRI (fMRI) data reveal that light therapy enhances brain connectivity, particularly between the habenula and the medial orbitofrontal cortex (mOFC). These changes are associated with reduced withdrawal symptoms and addiction severity, highlighting the ...
Jinhui Li +10 more
wiley +1 more source
Fibromyalgia and anxiety disorder [PDF]
, 2007 Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/OpenObjective: The etiology of fibromyalgia is unclear. The diagnosis is based on widespread pain and muscular tenderness, but other symptoms often occur, such as
Ranavaya, Mohammed I +3 more
core
Advanced Science, EarlyView.This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu +6 more
wiley +1 more source
Affect, Interpersonal Behaviour and Interpersonal Perception During Open-Label, Uncontrolled Paroxetine Treatment of People with Social Anxiety Disorder: A Pilot Study [PDF]
, 2018 Background: Laboratory-based research with community samples has suggested changes in affective, behavioural and cognitive processes as possible explanations for the effects of serotonergic medications.
Bleau, Pierre +5 more
core +1 more source
The Microbiota Shapes Central Nervous System Myelination in Early Life
Advanced Science, EarlyView.Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch +13 more
wiley +1 more source
Effectiveness and safety of Jiuwei Zhenxin granules for treating generalized anxiety disorder: A randomized controlled trial [PDF]
, 2022 Xue Wang +12 more
openalex +1 more source
Advanced Science, EarlyView.Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang +7 more
wiley +1 more source