Results 141 to 150 of about 2,401,638 (302)
, 2012 This chapter focuses on supporting the families of children and young people with ID, autism and anxiety. A parent support model for managing the anxiety of this group will be explored, and its implementation on a small group of parents will be ...
Gobrial, E. +2 more
core
VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, EarlyView.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source
Connecting the Dots: History Gathering in Anxiety Diagnosis
In this chapter, the case of Ms. A, a 33yearold married female, serves as a starting point to explore the complexities of diagnosing anxiety disorders. Ms. A presents with a yearlong struggle marked by excessive worry, fear, and physical symptoms such as
Martinez-Sosa, Natalie +1 more
core +1 more source
Advanced Science, EarlyView.Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan +10 more
wiley +1 more source
On the neural basis of emotion processing in depression and anxiety : an fMRI study in outpatients [PDF]
, 2010 The wide implications of emotions in our social and private life, and the far-reaching consequences of dysfunctions in emotional processing, have made emotion one of the most widely studied psychological processes.
Demenescu, Liliana Ramona +1 more
core +1 more source
Advanced Science, EarlyView.Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo +10 more
wiley +1 more source
Pakistan Journal of Pharmaceutical SciencesAutism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by persistent deficits in social communication and interaction, alongside restricted and repetitive behaviors.
Michel Bourin
doaj +1 more source
Advanced Science, EarlyView.Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu +16 more
wiley +1 more source
, 2017 Severe health anxiety (SHA) shares features with obsessive-compulsive disorder (OCD) and in recent years there has been a debate as to whether the two disorders may represent two facets of the same condition.
Axelsson, Erland, +11 more
core +1 more source
Advanced Science, EarlyView.How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Yu Lu +14 more
wiley +1 more source