Results 121 to 130 of about 626,359 (311)

Treatments for comorbid anxiety and mood disorders

, 2016
Anxiety disorders (such as generalized anxiety disorder) are highly comorbid with depression, and the polyvalent effects from herbal medicines can potentially target a range of symptoms that commonly overlap in these disorders. Herbal medicines with mood-
Sarris, Jerome (R18802), Mischoulon, David, David Mischoulon, Jerome Sarris   +3 more
core   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source

“Permission to Come Out of The Dark”: A Qualitative Analysis of Male and Female Veterans’ Use of a Telehealth Art Therapy Intervention

Inquiry: The Journal of Health Care Organization, Provision, and Financing
Telehealth has expanded access to psychotherapy for veterans, yet little is known about how art therapy is experienced in remote formats. In this paper, we describe a thematic analysis that involved male and female veterans with PTSD and TBI (aside from ...
Kim Valldejuli MA, ATR-BC, Kristyn S. Stickley MA, ATR-BC, LPCC, Victoria Schwachter MA, ATR-BC, LPAT, Heather Spooner MA, ATR-BC, LPAT, John B. Williamson PhD, ABPP-CN, Girija Kaimal EdD, MA, ATR-BC   +5 more
doaj   +1 more source

The Crossroads of Addiction and Anxiety

This chapter introduces Mr. Z, a 35yearold man with a history of substance use disorder and anxiety symptoms. Mr. Z’s life has been significantly impacted by his addiction to opioids and alcohol. He presents with symptoms of constant worry, irritability,
Martinez Garza, David M., Salloum, Ihsan M.   +1 more
core   +1 more source

Anxiety disorders: traditional nursing management and new non-pharmacological approaches

, 2023
openIntroduzione - I disturbi d’ansia rappresentano il tipo più comune di malattia mentale e sebbene sia stato dimostrato che questi disturbi sono condizioni trattabili, solo il 60% dei pazienti risponde ai percorsi di cura tradizionali per cui si e ...
BIZZOTTO, SVEVA
core  

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Measuring Anxiety Symptoms – Psychometric Properties of the Dutch Version of the Lehrer–Woolfolk Anxiety Scale Questionnaire

Psychological Test Adaptation and Development
: Introduction: The Lehrer–Woolfolk Anxiety Symptom Questionnaire (LWASQ) is a self-report questionnaire based on the tripartite model of Lang (1971) for measuring treatment progress. However, so far little is known about its psychometric qualities.
Vivian Peerbooms, Th. Michael van den Boogaard, Kim Melchior, Joran Jongerling, Colin van der Heiden   +4 more
doaj   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source