Results 151 to 160 of about 1,167,573 (358)

Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectives on Nanodelivery Strategies

Advanced Science, EarlyView.
Brain diseases involve multilayered metabolic disruptions that reshape cellular interactions and microenvironments. This review outlines core metabolic features across disease states and presents emerging nanodelivery strategies as precision tools to reprogram pathological metabolism.
Jingyi Zhou, Chen Jiang
wiley   +1 more source

Anxiety Disorders in Primary Care [PDF]

, 1997
I.V. Miclujia
openalex   +1 more source

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

Advanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo, Qiancheng Mao, Xinyu Fang, Liuxuan Huang, Haoquan Tian, Wenguang Yang, Feiyue Zhou, Ke Ma   +7 more
wiley   +1 more source

Posttraumatic Stress Disorder-Related Differences in Neural Connectivity Among Female Trauma Survivors

Biological Psychiatry Global Open Science
Background: Posttraumatic stress disorder (PTSD) is a debilitating condition that disproportionately impacts females. Prior research indicates that males with PTSD exhibit hypoconnectivity of frontal brain regions measured with resting ...
Natalie C. Noble, Mohammad S.E. Sendi, Julia B. Merker, Samantha R. Linton, Theresa K. Webber, Russell T. Toll, Amit Etkin, Wei Wu, Kerry J. Ressler, Antonia V. Seligowski   +9 more
doaj   +1 more source

DSM-III generalized anxiety disorder: An empirical investigation of more stringent criteria

, 1985
Naomi Breslau, Glenn C. Davis
openalex   +1 more source

Cognitive behavioural therapy improved symptoms in children with anxiety disorders [PDF]

, 1998
Gail A. Bernstein, Amy R. Perwien, CARRIE M. BORCHARDT   +2 more
openalex   +1 more source

Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury

Advanced Science, EarlyView.
This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li, Hongyuan Xing, Yifan Shen, Meng Chen, Bowen Lyu, Xiaofeng Yang, Li Sun, Chao Jiang, Jianyu Lv, Xin Ding, Zhongyang Gao, Yue Wang   +11 more
wiley   +1 more source

Social Anxiety Disorder

New England Journal of Medicine, 2003
Is common, underdiagnosed, impairing, and treatable The hallmark of social anxiety disorder is extreme and persistent fear of embarrassment and humiliation.1 People with this condition (which is also known as social phobia) often avoid participating in social and public activities, such as public speaking, social gatherings, or meetings.
openaire   +6 more sources

Igfbp2 Downregulation in PVT‐CeA Glutamatergic Circuits Drives Neonatal Anesthesia‐Induced Fear Memory Deficits

Advanced Science, EarlyView.
Repeated neonatal sevoflurane exposure impairs adolescent fear memory through Igfbp2 downregulation in paraventricular thalamus‐central amygdala glutamatergic projections. Restoring Igfbp2 or activating this circuit rescues memory deficits, neuronal excitability, and spine density, identifying a precise molecular target for preventing anesthesia ...
Weiming Zhao, Ke Peng, Baojian Zhao, Xiaowen Meng, Gang Wang, Hanbing Xu, Li Deng, Xisheng Shan, Yichan Wang, Qiya Xu, Yanan Gao, Ruixia Weng, Hong Liu, Jin Tao, Huayue Liu, Shaoyong Song, Fuhai Ji   +16 more
wiley   +1 more source

Consumer experiences of synchronous telepsychology within a community anxiety disorder clinic: A qualitative study

Health Literacy and Communication Open
Background The provision of psychological services via telecommunication modalities, including videoconferencing, has increased in recent years, particularly subsequent to the COVID-19 pandemic.
Emma St John, Emma Minchin, Denise Milicevic, Laura Kirsten, Sabrina Agius, Ilona Juraskova   +5 more
doaj   +1 more source