Results 11 to 20 of about 522,524 (341)
The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022 Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee +16 more
wiley +1 more source
Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety
Nature Communications, 2020 Dysregulated prefrontal control over amygdala has been implicated in the etiology of stress-related psychiatric disorders. Here, the authors show that the dysregulation preferentially occurs in amygdala neurons that are mono- but not bi-directionally ...
Wei-Zhu Liu +10 more
doaj +1 more source
European Psychiatry, 2023 Introduction Many studies have investigated whether there exist predictors of good response to antimanic drugs in bipolar disorder (BD). However, these factors predict response or only indicate benign illness course. Objectives To shed some light on the
G. Anmella +11 more
doaj +1 more source
Translational Psychiatry, 2023 Genome-wide (GWAS) and copy number variant (CNV) association studies have reproducibly identified numerous risk alleles associated with bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ), but biological characterization of ...
Sevilla D. Detera-Wadleigh +32 more
doaj +1 more source
The Yale-Brown Obsessive-Compulsive scale: factor structure of a large sample
Frontiers in Psychiatry, 2010 The Yale Brown Obsessive-Compulsive scale (Y-BOCS) is a semi-structured interview considered to be the gold standard in the measurement of obsessive-compulsive disorder (OCD) severity, yet findings about its factorial structure are conflicting.
Gideon Anholt +9 more
doaj +1 more source
Translational Psychiatry, 2021 Individuals with a social anxiety disorder (SAD) show hypofunctioning of the hypothalamus–pituitary-gonadal (HPG) axis, which is linked to social fear and avoidance behavior.
Moniek H. M. Hutschemaekers +4 more
doaj +1 more source
Frontiers in Neuroscience, 2020 Chronic or prolonged exposure to stress ranks among the most important socioenvironmental factors contributing to the development of neuropsychiatric diseases, a process generally associated with loss of inhibitory tone in amygdala.
Han-Qing Pan +18 more
doaj +1 more source
American Journal of Community Psychology, Volume 70, Issue 3-4, Page 265-277, December 2022., 2022 Abstract Community violence exposure is prevalent among urban and marginalized adolescents. Although there is strong evidence that community violence exposure is associated with negative consequences, prior studies and theories suggest that these associations may differ as a function of specific characteristics of exposure.
Sarah K. Pittman, Albert D. Farrell
wiley +1 more source
New Therapeutic Targets for Mood Disorders
The Scientific World Journal, 2010 Existing pharmacological treatments for bipolar disorder (BPD) and major depressive disorder (MDD) are often insufficient for many patients. Here we describe a number of targets/compounds that clinical and preclinical studies suggest could result in ...
Rodrigo Machado-Vieira +8 more
doaj +1 more source
American Journal of Community Psychology, Volume 70, Issue 3-4, Page 314-326, December 2022., 2022 Abstract This randomized controlled trial examined the impact of The Connection Project, an experiential, relationship‐focused intervention designed to improve school belongingness and decrease symptoms of depression and loneliness among new college students.
Meghan A. Costello +6 more
wiley +1 more source