Nature CommunicationsUnderstanding how distinct functional circuits are coordinated to fine-tune mood and behavior is of fundamental importance. Here, we observe that within the dense projections from basolateral amygdala (BLA) to bed nucleus of stria terminalis (BNST ...
Ren-Wen Han +4 more
doaj +1 more source
Diet transition to a high-fat diet for 3 weeks reduces brain omega-3-fatty acid levels, alters BDNF signaling and induces anxiety & depression-like behavior in adult rats [PDF]
, 2012 Background: The consumption of diets high in calories and low in nutrient value is becoming increasingly common in modern society, which can lead to metabolic disorders like diabetes and obesity, and potentially to psychiatric disorders.
Fernando Gomez-Pinilla +2 more
core +1 more source
Men and women from the STRIDE clinical trial: An assessment of stimulant abstinence symptom severity at residential treatment entry [PDF]
, 2015 Background and Objectives Gender‐specific factors associated with stimulant abstinence severity were examined in a stimulant abusing or dependent residential treatment sample (N = 302).
Burrow, Allison +6 more
core +2 more sources
Potential antidepressant effects of scutellaria baicalensis, hericium erinaceus and rhodiola rosea [PDF]
, 2020 Recent studies focused on the pharmacology and feasibility of herbal compounds as a potential strategy to target a variety of human diseases ranging from metabolic to brain disorders. Accordingly, bioactive ingredients which are found within a variety of
Biagioni, F +5 more
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub +24 more
wiley +1 more source
Treating the patient not just the disease? : Delving deeper into the possible link between affective disorders and coronary heart disease through statistical analysis of a random sample of Maltese people [PDF]
, 2014 Background: Ischemic heart disease is the leading cause of death in Males in Malta and globally. Affective disorders are the commonest psychological problem.
Calleja, Neville, Debono, David
core
Efficacy of the Unified Protocol for transdiagnostic treatment of comorbid psychopathology accompanying emotional disorders compared to treatments targeting single disorders [PDF]
, 2018 OBJECTIVE: This study aimed to examine whether the Unified Protocol (UP), a transdiagnostic cognitive-behavioral therapy for emotional disorders (i.e., anxiety, mood, and related disorders), is efficacious in the treatment of co-occurring emotional ...
Ametaj, Amanda +6 more
core +2 more sources
Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni +19 more
wiley +1 more source
BMC Medical Informatics and Decision MakingBackground This study investigates how variations in Major Depressive Disorder (MDD) symptoms (HAM-D) are associated in a predictive model with randomized clinical trial (RCT) arm assignment between SSRIs and SNRIs.
Xinyu Qin +7 more
doaj +1 more source
Frontiers in PsychiatryBackgroundInteroceptive exposure (IE) to feared bodily sensations is a core component of cognitive–behavioral therapy for panic disorder (PD), but standard office-based IE can be perceived as aversive and tedious, potentially limiting engagement ...
Ricardo William Muotri +4 more
doaj +1 more source