Results 271 to 280 of about 71,529 (343)

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

Decreasing Preoperative Anxiety in Patients with Newly Available Multimodal Approaches-A Narrative Review. [PDF]

J Clin Med
Kisielewska W, Kościółek M, Kowalczyk W, Mitura B, Mitura L, Rogula S, Leszczyński PK, Antosik K, Mitura K.   +8 more
europepmc   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Daily Administration of Agmatine Reduced Anxiety-like Behaviors and Neural Responses in the Brains of Male Mice with Persistent Inflammation in the Craniofacial Region. [PDF]

Nutrients
Iwamoto Y, Piriyaprasath K, Yusuf ASH, Hasegawa M, Kakihara Y, Sato T, Fujii N, Yamamura K, Okamoto K.   +8 more
europepmc   +1 more source

The Effects of Elinzanetant on Simulated Driving Performance in Healthy Women: A Randomized Phase I Study

Clinical and Translational Science, Volume 18, Issue 7, July 2025.
ABSTRACT Elinzanetant is a dual neurokinin–1 and –3 receptor antagonist in development for treating vasomotor symptoms associated with menopause. Its central nervous system action and bedtime dosing could produce next‐morning residual effects that impact safety when driving.
Klaus Francke, Stefan Klein, Jennifer Burke, Marcus‐Hillert Schultze‐Mosgau, Gary Kay   +4 more
wiley   +1 more source

Neuroactive steroid exposure impacts neurodevelopment: Comparison of human and rodent placental contribution

Journal of Neuroendocrinology, Volume 37, Issue 7, July 2025.
Abstract The placenta is a fetal endocrine organ that secretes many neuroactive factors, including steroids, that play critical roles in brain development. The study of the placenta‐brain axis and the links between placental function and brain development represents an emerging research area dubbed “neuroplacentology.” The placenta drives many ...
Claire‐Marie Vacher, Alex Tsompanidis, Morgan R. Firestein, Anna A. Penn   +3 more
wiley   +1 more source

Anxiolytic, Antidepressant, and Anticholinesterase Effects of Essential Oil from <i>Myrcia sylvatica</i> (G.Mey.) DC. [PDF]

Biomolecules
Silva Júnior AQD, Garcia MM, Farias WDS, Sousa DJDA, Barroso AS, Figueiredo PLB, Santos GBD, de Oliveira RB, Mourão RHV.   +8 more
europepmc   +1 more source

Long‐Term Clinical Response to Medical Treatment, Behavioral Therapy, or Their Combination in Cats With Hyperesthesia Syndrome

Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT Background Hyperesthesia syndrome (HS) is a common yet poorly understood condition in cats, with hypothesized neurological and behavioral causes and limited data on outcomes and treatment. Objectives This study aimed to describe the clinical outcomes and the treatment response of 28 cats with HS, managed through various therapeutic strategies.
Claudia Pauciulo, Stefania Uccheddu, Andrea Corda, Federica Biggio, Daniele Sebastian Corlazzoli, Marika Menchetti, Antonella Gallucci   +6 more
wiley   +1 more source

Nationwide trends in diagnosed sedative, hypnotic or anxiolytic use disorders in adolescents and young adults enrolled in Medicaid: 2001-2019. [PDF]

Addiction
Bushnell G, Lloyd K, Olfson M, Gerhard T, Keyes K, Cerdá M, Hasin D.   +6 more
europepmc   +1 more source

Hope among patients discharged from an intensive care unit: A prospective cohort study

Nursing in Critical Care, Volume 30, Issue 4, July 2025.
Abstract Background Hope is important during critical illness due to the uncertainty and loss of control in the patient's life. Following intensive care, hope might provide a therapeutic effect and increase coping, leading to improved recovery. Aim To describe the levels of hope in patients during the first year after ICU treatment, and to explore ...
Mona Austenå, Tone Rustøen, Milada Cvancarova Hagen, Åse Valsø, Kjetil Sunde, Kirsti Tøien   +5 more
wiley   +1 more source