Results 141 to 150 of about 23,910 (287)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid, Piyush Padhi, Mahsa Gifani, John S. Beck, Jacob P. Thomas, Gargi Khadse, Catherine Kudela, Gregory J. Phillips, Anumantha G. Kanthasamy, Scott E. Counts   +9 more
wiley   +1 more source

Current Approaches to Support Patients to Withdraw From Image and Performance Enhancing Drugs

Clinical Endocrinology, EarlyView.
ABSTRACT Image and performance‐enhancing drugs (IPEDs) include agents such as androgens, growth hormone, and erythropoietin, which are used to enhance appearance and physical performance. Androgens, also known as anabolic‐androgenic steroids (AAS), are the most used IPEDs worldwide.
Elizabeth Hyams, Bonnie Grant, Richard Quinton, Channa N. Jayasena   +3 more
wiley   +1 more source

Assessing patient perception following outpatient dermatological surgical procedures

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Despite receiving similar information about outpatient dermatologic surgical procedures, some patients still hold misconceptions about the nature of their lesions and the treatment. No studies have been done to understand this difference in the perception of surgery.
Ana Morelló‐Vicente, Inés Oteiza‐Rius, Elisa María Gómez‐González, Ane Carrera‐Gabilondo, Deiane Marcos‐Muñagorri, Mónica María Fernández‐Álvarez, Rafael Salido‐Vallejo   +6 more
wiley   +1 more source

The Efficacy Of Benzodiazepines As Acute Anxiolytics In Children: A Meta-Analysis

, 2017
Objective: Current practice guidelines do not recommend benzodiazepines for acute management of anxiety disorders in pediatric patients. However, in procedural settings, benzodiazepines are commonly used to relieve acute pre-procedural stress.
Kuang, Heide
core   +1 more source

Prevalence of binge eating disorder symptoms and associated characteristics in Danish adults with type 2 diabetes: A cross‐sectional study

Diabetic Medicine, EarlyView.
Abstract Aims Coexistence of binge eating disorder (BED) and type 2 diabetes is linked to poor health outcomes, but data on the prevalence and clinical profile of BED symptoms remain limited and inconsistent. We estimated the prevalence of BED symptoms and examined their associated clinical characteristics in Danish adults with type 2 diabetes ...
Pernille Fiil Nybo, Sidsel Louise Domazet, Michael Einar Røder, Jakob Linnet   +3 more
wiley   +1 more source

Are Smartphones Associated With Stress and Poor Sleep Quality? The Perspective of Dental Students

European Journal of Dental Education, EarlyView.
ABSTRACT Objective This study aimed to examine the association between problematic smartphone use, sleep quality and psychosocial factors among dental students, and to identify key behavioural and psychological predictors of high‐risk smartphone use within this academically demanding population.
Ahmet Şanlıdağ, Tuğba Aydın, Melih Can Uzel, Çiğdem Yıldırım Navruz   +3 more
wiley   +1 more source

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source

Swiss Practice Recommendations for Chronic Prurigo Including Prurigo Nodularis

International Journal of Dermatology, EarlyView.
Chronic prurigo, including prurigo nodularis, is a chronic, often treatment‐refractory condition characterized by persistent pruritus and chronic scratch lesions. Advances in the understanding of its underlying pathophysiology have enabled the development of novel targeted therapies; however, management remains challenging due to the expanding range of
Simon M. Mueller, Helmut Beltraminelli, Wolf‐Henning Boehncke, Maximilian Böhm, Antonio Cozzio, Peter Häusermann, Ahmad Jalili, Antonios G. A. Kolios, Claudia Lang, Eva Loos, Christoph Schlapbach, Curdin Conrad   +11 more
wiley   +1 more source

Altered photoperiod affects behaviour in a key fish grazer, the thinlip grey mullet, Chelon ramada

Journal of Fish Biology, EarlyView.
Abstract The aim of this study is to address experimentally the immediate impacts of an alteration of the photoperiod, simulating an extreme artificial light pollution, on the behaviour and stress of a key grazer fish common in temperate coastal ecosystems in Europe, the thinlip grey mullet, Chelon ramada.
Caroline Roux, Alex Bois, Patrick Chèvre, Fabrice Vétillard, Philippe Jatteau, Marie‐Laure Bégout, Soizic Morin, Laure Carassou   +7 more
wiley   +1 more source