Results 151 to 160 of about 2,570 (163)

Identification of Two Imidazole Binding Sites and Key Residues for Substrate Specificity in Human Primary Amine Oxidase AOC3

Biochemistry, 2011
Human membrane primary amine oxidase (hAOC3; also known as vascular adhesion protein-1, VAP-1) is expressed upon inflammation in most tissues, where its enzymatic activity plays a crucial role in leukocyte trafficking. We have determined two new structures of a soluble, proteolytically cleaved form of hAOC3 (sAOC3), which was extracted from human ...
Elovaara, Heli, Kidron, Heidi, Parkash, Vimal, Nymalm, Yvonne, Bligt, Eva, Ollikka, Pauli, Smith, David, Pihlavisto, Marjo, Salmi, Marko, Jalkanen, Sirpa, Salminen, Tiina   +10 more
openaire   +3 more sources

Histamine oxidation in mouse adipose tissue is controlled by the AOC3 gene-encoded amine oxidase

Inflammation Research, 2009
Histaminergic status can modify adipose tissue (AT) development: histamine-free mice exhibit visceral obesity, and treatments with H3-antagonists reduce body weight gain. However, direct histamine effects on AT remain poorly documented: it has been observed that histamine stimulates lipolysis in rodent adipocytes when its oxidation by amine oxidases ...
Iffiú-Soltész, Zsuzsa, Wanecq, Estelle, Prévot, Danielle, Grès, Sandra, Carpéné, Christian   +4 more
exaly   +4 more sources

AOC3 Loss Promotes Imatinib Resistance in GIST by Stabilizing HK2 and Enhancing H3K18la‐Driven Myc Transcription

Molecular Carcinogenesis
ABSTRACT Gastrointestinal stromal tumor (GIST) frequently develops resistance to imatinib (IM). This study identifies AOC3 downregulation as a critical contributor to IM resistance. Analyzing clinical samples and IM‐sensitive/resistant GIST cell lines, we found AOC3 significantly decreased in resistant states.
Zhiyuan Guo, Linsen Zhou, Zhiqiang Wang, Haohai Jiang, Xinguo Zhu   +4 more
exaly   +3 more sources

Semicarbazide-sensitive amine oxidase substrates fail to induce insulin-like effects in fat cells from AOC3 knockout mice

Journal of Neural Transmission, 2007
Substrates of semicarbazide-sensitive amine oxidases (SSAO) stimulate glucose transport in adipocytes. To definitively demonstrate the involvement of SSAO in this insulin-like effect, glucose transport has been studied in fat cells from mice with a targeted deletion of AOC3, a gene encoding a SSAO called vascular adhesion protein-1.
S, Bour, D, Prévot, C, Guigné, C, Stolen, S, Jalkanen, P, Valet, C, Carpéné   +6 more
openaire   +2 more sources

Benzylamine antihyperglycemic effect is abolished by AOC3 gene invalidation in mice but not rescued by semicarbazide-sensitive amine oxidase expression under the control of aP2 promoter

Journal of Physiology and Biochemistry, 2012
Semicarbazide-sensitive amine oxidase (SSAO) is a transmembrane enzyme that metabolizes primary amines from endogenous or dietary origin. SSAO is highly expressed in adipose, smooth muscle and endothelial cells. In each of these cell types, SSAO is implicated in different biological functions, such as glucose transport activation, extracellular matrix ...
Grès, Sandra, Bour, Sandy, Valet, Philippe, Carpéné, Christian   +3 more
openaire   +2 more sources

Plain Language Summary of the manuscript: ROBIN: a randomised, double-masked, placebo-controlled Phase IIa study of the AOC3 inhibitor BI 1467335 in diabetic retinopathy

The above is a plain language summary of a publication developed with the authors of the original content which is published in a peer-reviewed scientific journal.
Dong Nguyen, Quan, P. Ehlers, Justis, S. Boyer, David, Jin, Xidong, Giani, Andrea, S. Ehrlich, Michael   +5 more
openaire   +1 more source

ω‐(5‐Phenyl‐2H‐tetrazol‐2‐yl)alkyl‐substituted hydrazides and related compounds as inhibitors of amine oxidase copper containing 3 (AOC3)

Archiv Der Pharmazie, 2022
Matthias Lehr
exaly  

High expression of semicarbazide-sensitive amine oxidase genes AOC2 and AOC3 , but not the diamine oxidase gene AOC1 in human adipocytes

Inflammation Research, 2003
A, Heniquez, G, Meissonnier, V, Visentin, D, Prévot, C, Carpéné   +4 more
openaire   +2 more sources

The function of proto-adipokine AOC3 during adipose tissue dysfunction in metabolic diseases

2022
Topel Batarlar, Hande, Davidsen, Laura Ingeborg, Egedal, Nadia Meincke, Park, Joo Hyun, Larsen, Bjørk Ditlev Marcher, Kornfeld, Jan-Wilhelm   +5 more
openaire   +1 more source

Inhibition of AOC3 protects against islet cell death caused by glucolipotoxicity

Diabetologie und Stoffwechsel
Lisa Naundorf, Timo Pöstges, Matthias Lehr, Martina Düfer   +3 more
openaire   +1 more source