Results 101 to 110 of about 20,895 (217)

Refining the Genetic Contribution to Type 2 Diabetes Subtypes

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9450-9460, October 2026.
ABSTRACT Background Type 2 diabetes (T2D) is a complex and highly heterogeneous disease driven in part by genetic predisposition and can be stratified into clinical subgroups to aid disease management. We recently grouped T2D subjects in the Qatar Biobank (QBB) cohort into Severe Insulin‐Deficient Diabetes (SIDD), Severe Insulin‐Resistant Diabetes ...
Nayra M. Al‐Thani, Salman M. Toor, Umm‐Kulthum Ismail Umlai, Usama Aliyu, Karsten Suhre, Omar M. E. Albagha   +5 more
wiley   +1 more source

Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis

Insect Molecular Biology, Volume 35, Issue 5, Page 556-575, October 2026.
RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour, Angelo José Rinaldi, Eulálio Gutemberg Dias dos Santos, Gabriely Teixeira Bhering Faria, Ana Márcia Escocard de Azevedo Manhães, Jorge Fernando Pereira, Alexander Machado Auad, Maria Goreti de Almeida Oliveira, Humberto Josué de Oliveira Ramos   +8 more
wiley   +1 more source

Predictors of in vitro response to somatostatin and dopamine receptor‐targeted treatments are lacking in clinically non‐functioning pituitary tumors

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Clinically non‐functioning pituitary neuroendocrine tumors (NF‐PitNETs) lack effective medical therapies, and the role of somatostatin receptor ligands (SRLs) and dopamine agonists (DAs) in this setting is controversial. We evaluated the in vitro response of NF‐PitNETs to multiple SRL and/or DA treatments, focusing on the role of receptor ...
Claudia Campana, Jessica Amarù, Diego Criminelli Rossi, Anna Arecco, Paolo Nozza, Mara Boschetti, Gianluigi Zona, Diego Ferone, Marica Arvigo, Federico Gatto   +9 more
wiley   +1 more source

The Unexpected Discovery of Paleocene? Coals in Outcrops Thought to Be Cambrian, Al Huqf, Oman

Journal of Petroleum Geology, Volume 49, Issue 4, Page 1179-1194, October 2026.
ABSTRACT Two brown organic deposits were encountered whilst investigating kaolinitic claystones thought to occur at the base of a Cambrian formation at outcrop. The age of these organic deposits is probably Paleocene from palynology. Organic petrography shows that they are subbituminous coals with some oil source potential.
Mohammed H. Al Kindi, Alan P. Heward, Lorraine B. Eglinton, Steve R. Packer, Darrin T. Stead   +4 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Pyrazolyl Thioureas (PTUs) as SIRT1 and SIRT2 Inhibitors

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Pyrazolyl thioureas were designed and synthesized as sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) inhibitors. 6a (IC50 (SIRT1) = 5.3 µM; IC50 (SIRT2) = 2.2 µM) and 7f (IC50 (SIRT1) = 12.4 µM; IC50 (SIRT2) = 13.6 µM) showed micromolar inhibition on target enzymes and HepG2‐based assays confirmed a SIRT2‐mediated effect on tubulin acetylation. Docking studies
Matteo Lusardi, Cecilia Astigiano, Deianira Bellitto, Matteo Raineri, Giorgia Guccione, Annalisa Salis, Elena Cichero, Chiara Brullo, Marco Ponassi, Santina Bruzzone, Andrea Spallarossa   +10 more
wiley   +1 more source

Near‐Field Acoustic and Gravity Wave Modes in the Ionosphere Triggered by Ground Motion and Tsunami During the 2024 Mw7.4 Hualien Earthquake

Journal of Geophysical Research: Atmospheres, Volume 131, Issue 18, 28 September 2026.
Abstract The interaction between the atmosphere and other components of the Earth system, such as the solid Earth and the oceans, remains an open and active area of research. In particular, the dynamic response of the ionosphere to forcing from below, such as earthquakes and tsunamis, is not yet fully understood.
Oluwasegun M. Adebayo, Lucie Rolland, Esfhan A. Kherani, Tung‐Yuan Hsiao, Loren C. Chang, Alexandre A. Pimenta, Virginia A. Klausner   +6 more
wiley   +1 more source

Early life factors documented in electronic health records predict recurrent acute otitis media. [PDF]

PLoS One
Hurst JH, Zhao C, Raynor EM, Lee JW, Gitomer SA, Woods CW, Kelly MS, Smith MJ, Goldstein BA.   +8 more
europepmc   +1 more source

Diagnostic accuracy and management of suspected acute otitis media: A multi-continental survey of primary care physicians using tympanic membrane images in clinical cases. [PDF]

Eur J Gen Pract
Lindman I, Ahlstrand L, Lundberg T, Moberg A, Mossberg K, Caballero L, Heal C, Coenen S, Picard I, Kaduszkiewicz H, Escales C, Hansmann-Wiest J, Fitzgerald N, Ito T, Haugen Fossum G, Braend AM, Eales O, Ngcobo S, Llor C, Van Hecke O, Ebell M, Gunnarsson R, Sundvall PD.   +22 more
europepmc   +1 more source

Colitis-Associated Colorectal Cancer-STAT3 Inhibition as a Preventive Strategy. [PDF]

Int J Mol Sci
Robinson P, Hoang T, Italia Z, Italia Z, Chang CC, Damania AV, Ajami NJ, Rodriguez E, Kasembeli M, Zorrilla LH, Soto LMS, Pham C, Nguyen J, Zamil Y, Durán CAC, Bharadwaj U, Mahalingam R, Tweardy DJ.   +17 more
europepmc   +1 more source

Improving Guideline-concordant Antibiotic Use for Acute Otitis Media in a Pediatric Primary Care Network. [PDF]

Pediatr Qual Saf
Sweeney S, Simon A, Morano L, Chang J, Goebel K, Campbell K, Morelli SA, Kronman MP.   +7 more
europepmc   +1 more source