Results 91 to 100 of about 83,894 (241)
British Journal of Pharmacology, EarlyView.Abstract Cardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from endothelial dysfunction and plaque formation to erosion, rupture and myocardial injury.
Shreya Mahabhashyam +4 more
wiley +1 more source
Cell Proliferation, EarlyView.PCSK9 aggravates AAA by promoting ferroptosis in VSMCs. In the pathological AAA environment, PCSK9 upregulation triggers ferritinophagy‐dependent degradation of FTH1, leading to Fe2+ release, triggering lipid peroxidation and ferroptosis, exacerbating AAA.
Mengdie Xia +13 more
wiley +1 more source
Tobacco smoking and the risk of aortic aneurysm in the UK biobank
Scientific ReportsSmoking is an established risk factor for aortic aneurysm, however, few studies have investigated the associations with different aortic aneurysm subsites.
Lili Zheng +6 more
doaj +1 more source
Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases
Cell Proliferation, EarlyView.m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du +7 more
wiley +1 more source
مجله دانشگاه علوم پزشکی بیرجند, 2015 Background and Aim: Abdominal aortic aneurysm is an important mortality factor especially in old men. The present study aimed at investigating prevalence of abdominal aortic aneurysm in people over 65 years old who referred to the ultrasonic centers in ...
Mahyar Mohamadifard +2 more
doaj
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, EarlyView.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
Journal of Advanced Nursing, EarlyView.ABSTRACT Aim To evaluate the quality of action research studies using the Quality Assessment Action Research Checklist (QuARC) and to assess its utility as a tool for quality appraisal. Design A hybrid systematic narrative review following Turnbull et al.'s six‐stage methodology and reported in accordance with PRISMA 2020 guidance.
Mary Casey +4 more
wiley +1 more source