Results 31 to 40 of about 726,988 (249)

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

Advanced Science, EarlyView.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma, Fei Ma, Ning Ding, Lin Xie, Anning Yang, Jiangyong Shen, Yun jiao, Kai Wu, YueE Chai, Zhigang Bai, Jiantuan Xiong, Nan Li, Huiping Zhang, Yideng Jiang   +13 more
wiley   +1 more source

Validation of numerical simulation methods in aortic arch using 4D Flow MRI

Heart and Vessels, 2017
Computational fluid dynamics (CFD) are the gold standard in studying blood flow dynamics. However, CFD results are dependent on the boundary conditions and the computation model. The purpose of this study was to validate CFD methods using comparison with
S. Miyazaki, K. Itatani, T. Furusawa, T. Nishino, M. Sugiyama, Y. Takehara, S. Yasukochi   +6 more
semanticscholar   +1 more source

Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection

Advanced Science, EarlyView.
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng, Yansong Wang, Haoyue Huang, Yinglong Ding, Jun Wang, Meili Liu, Kun Song, Lianbo Shao, You Yu, Ziying Yang, Zhenya Shen   +10 more
wiley   +1 more source

Hypothermia and cerebral protection strategies in aortic arch surgery: a comparative effectiveness analysis from the STS Adult Cardiac Surgery Database

European Journal of Cardio-Thoracic Surgery, 2017
OBJECTIVES Hypothermic circulatory arrest is essential to aortic arch surgery, although consensus regarding optimal cerebral protection strategy remains lacking. We evaluated the current use and comparative effectiveness of hypothermia/cerebral perfusion
B. Englum, Xia He, B. Gulack, A. Ganapathi, J. Mathew, M. Brennan, B. Reece, B. Keeling, B. Leshnower, E. Chen, J. Jacobs, V. Thourani, Chad G. Hughes   +12 more
semanticscholar   +1 more source

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Advanced Science, EarlyView.
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang   +13 more
wiley   +1 more source

Estimate of genetic variants using CNV‐Seq for fetuses with oligohydramnios or polyhydramnios

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
The overall detection rate of clinically significant findings was 8%, with 5.0% in the isolated group and 11.0% in non‐isolated group. Non‐isolated group especially oligohydramnios subgroup is inclined to obtained more pathogenicity genetic anomalies and to terminate their pregnancy outcome.
Panlai Shi, Yaqin Hou, Duo Chen, Huanan Ren, Yanjie Xia, Xiangdong Kong   +5 more
wiley   +1 more source

In Situ Laser Fenestration Is a Feasible Method for Revascularization of Aortic Arch During Thoracic Endovascular Aortic Repair

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2017
Background Reconstruction of the aortic major branches during thoracic endovascular aortic repair is complicated because of the complex anatomic configuration and variation of the aortic arch.
J. Qin, Zhen Zhao, Ruihua Wang, K. Ye, Weimin Li, Xiao-bing Liu, Guang Liu, Chaoyi Cui, Hui-hua Shi, Zhiyou Peng, Fukang Yuan, Xinrui Yang, Min Lu, Xin-tian Huang, M. Jiang, Xin Wang, M. Yin, Xinwu Lu   +17 more
semanticscholar   +1 more source

Self‐gated, dynamic contrast‐enhanced magnetic resonance imaging with compressed‐sensing reconstruction for evaluating endothelial permeability in the aortic root of atherosclerotic mice

NMR in Biomedicine, Volume 36, Issue 1, January 2023., 2023
Atherosclerotic plaques at high risk of causing cardiovascular events are characterized by a prominent inflammatory infiltrate accompanied by the presence of an extensive network of leaky microvessels. In this paper, we present a dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) acquisition and compressed sensing reconstruction to aortic ...
Claudia Calcagno, John A. David, Abdallah G. Motaal, Bram F. Coolen, Thijs Beldman, Alexandra Corbin, Arnav Kak, Sarayu Ramachandran, Alison Pruzan, Arthi Sridhar, Raphael Soler, Christopher M. Faries, Zahi A. Fayad, Willem J. M. Mulder, Gustav J. Strijkers   +14 more
wiley   +1 more source

Fate of the dissected aortic arch after ascending replacement in type A aortic dissection†

European Journal of Cardio-Thoracic Surgery, 2017
OBJECTIVES To evaluate the fate of a dissected aortic arch after limited surgical repair of type A aortic dissection. METHODS Of the 271 patients operated for acute type A dissection between 2001 and 2015, 86 (age 57 ± 13 years, 74% men) with ...
B. Rylski, N. Hahn, F. Beyersdorf, S. Kondov, M. Wolkewitz, P. Blanke, T. Plonek, M. Czerny, M. Siepe   +8 more
semanticscholar   +1 more source

Mesenteric thrombosis: An unusual complication of severe acute pancreatitis—Report of two cases

Advances in Digestive Medicine, EarlyView.
Abstract The incidence of acute pancreatitis is 34 per 100 000 people in the general population and is on the rise. Approximately 15% to 20% of all patients experience severe pancreatitis, with a mortality rate nearing 20%. This condition is often linked to vascular complications, although mesenteric thrombosis is a rare presentation.
Asya Zubillaga‐Mares, Erika Barlandas‐Quintana, Aranza Judith Sánchez‐Lopez, Minnet Serrano‐Sanchez, Javier Meza‐Hernandez, Alejandra Nuñez‐Venzor   +5 more
wiley   +1 more source