The Genetics of Thoracic Aortic Aneurysms and Dissection: A Clinical Perspective
Biomolecules, 2020 Thoracic aortic aneurysm and dissection (TAAD) affects many patients globally and has high mortality rates if undetected. Once thought to be solely a degenerative disease that afflicted the aorta due to high pressure and biomechanical stress, extensive ...
Nicolai P Ostberg +3 more
semanticscholar +1 more source
TGFβ (transforming growth factor-β) blockade induces a human-like disease in a nondissecting mouse model of abdominal aortic aneurysm [PDF]
, 2017 Objective-Current experimental models of abdominal aortic aneurysm (AAA) do not accurately reproduce the major features of human AAA. We hypothesized that blockade of TGF beta (transforming growth factor-beta) activity-a guardian of vascular integrity ...
Clément, Marc +12 more
core +2 more sources
Advanced Science, EarlyView.Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen +18 more
wiley +1 more source
Association of Aortic Aneurysms and Dissections With Subarachnoid Hemorrhage
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background It is uncertain whether aortic diseases, such as aneurysm and dissection, are associated with intracranial aneurysm formation and aneurysmal subarachnoid hemorrhage (SAH). Methods and Results We used data on claims between 2008 and 2015 from a
Mais Al‐Kawaz +3 more
doaj +1 more source
ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy
Advanced Science, EarlyView.Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie +11 more
wiley +1 more source
Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰
EBioMedicine, 2019 Background: Aortic dissection is a severe inflammatory vascular disease with high mortality and limited therapeutic options. The hallmarks of aortic dissection comprise aortic inflammatory cell infiltration and elastic fiber disruption, highlighting the ...
Guan Lian +11 more
doaj
A case report of aortic root repair using a pericardial autograft for type A aortic dissection
Journal of Cardiothoracic Surgery, 2020 Background Acute type A aortic dissection with a dissection flap extending into the sinus segment often involves the commissures and the coronary ostia.
Yi Chang +3 more
doaj +1 more source
Journal of Cardiothoracic Surgery, 2023 Background Traumatic aortic dissection with traumatic diaphragmatic hernia is a rare traumatic disease. The purpose of this article is to investigate the imaging characteristics and treatment strategies for traumatic diaphragmatic hernia with aortic ...
Hao-Hao Wu +2 more
doaj +1 more source
Repair of stent graft-induced retrograde type A aortic dissection using the E-vita open prosthesis† [PDF]
, 2017 OBJECTIVES Stent graft-induced retrograde type A dissection is a life-threatening complication after endovascular treatment of acute aortic type B dissections.
Czerny, Martin +6 more
core
Molecular and Genetic Insights into Thoracic Aortic Dilation in Conotruncal Heart Defects [PDF]
, 2016 Thoracic aortic dilation (AD) has commonly been described in conotruncal defects (CTDs), such as tetralogy of Fallot, double outlet right ventricle and transposition of the great arteries, and truncus arteriosus.
Kay, W. Aaron
core +2 more sources