Results 91 to 100 of about 736,331 (320)

Proteomic Profiling of the Large‐Vessel Vasculitis Spectrum Identifying Shared Signatures of Innate Immune Activation and Stromal Remodeling

Arthritis &Rheumatology, EarlyView.
Objective Takayasu arteritis (TAK) and giant cell arteritis (GCA), the most common forms of large‐vessel vasculitis (LVV), can result in serious morbidity. Understanding the molecular basis of LVV should aid in developing better biomarkers and treatments. Methods Plasma proteomic profiling of 184 proteins was performed in two cohorts. Cohort 1 included
Robert T. Maughan, Erin Macdonald‐Dunlop, Lubna Haroon‐Rashid, Louise Sorensen, Natalie Chaddock, Shauna Masters, Andrew Porter, Marta Peverelli, Charis Pericleous, Andrew Hutchings, James Robinson, Taryn Youngstein, Raashid A. Luqmani, Justin C. Mason, Ann W. Morgan, James E. Peters   +15 more
wiley   +1 more source

Detecting Heart Disease from Multi-View Ultrasound Images via Supervised Attention Multiple Instance Learning [PDF]

MLHC 2023, 2023
Aortic stenosis (AS) is a degenerative valve condition that causes substantial morbidity and mortality. This condition is under-diagnosed and under-treated. In clinical practice, AS is diagnosed with expert review of transthoracic echocardiography, which produces dozens of ultrasound images of the heart.
arxiv  

Identifying the Severity of Heart Valve Stenosis and Regurgitation Among a Diverse Population Within an Integrated Health Care System: Natural Language Processing Approach

JMIR Cardio
BackgroundValvular heart disease (VHD) is a leading cause of cardiovascular morbidity and mortality that poses a substantial health care and economic burden on health care systems.
Fagen Xie, Ming-sum Lee, Salam Allahwerdy, Darios Getahun, Benjamin Wessler, Wansu Chen   +5 more
doaj   +1 more source

A coupling strategy for a 3D-1D model of the cardiovascular system to study the effects of pulse wave propagation on cardiac function [PDF]

arXiv, 2021
The impact of increased stiffness and pulsatile load on the circulation and their influence on heart performance have been documented not only for cardiovascular events but also for ventricular dysfunctions. For this reason, computer models of cardiac electromechanics (EM) have to integrate effects of the circulatory system on heart function to be ...
arxiv  

Progression of Hypertrophy and Myocardial Fibrosis in Aortic Stenosis

Circulation Cardiovascular Imaging, 2018
Background: Aortic stenosis is accompanied by progressive left ventricular hypertrophy and fibrosis. We investigated the natural history of these processes in asymptomatic patients and their potential reversal post-aortic valve replacement (AVR). Methods:
Russell J Everett, L. Tastet, M. Clavel, C. Chin, R. Capoulade, V. Vassiliou, J. Kwieciński, M. Gómez, E. V. van Beek, A. White, S. Prasad, É. Larose, C. Tuck, S. Semple, D. Newby, P. Pibarot, M. Dweck   +16 more
semanticscholar   +1 more source

Transcatheter Aortic Valve Replacement in Low-risk Patients With Bicuspid Aortic Valve Stenosis.

JAMA cardiology, 2020
Importance The outcomes of transcatheter aortic valve replacement (TAVR) in low-risk patients with bicuspid aortic valve stenosis have not been studied in a large scale, multicentered, prospective fashion.
J. Forrest, Basel Ramlawi, G. Michael Deeb, F. Zahr, Howard K. Song, Neal S. Kleiman, S. Chetcuti, H. Michelena, A. Mangi, Jeffrey A. Skiles, Jian Huang, J. Popma, M. Reardon   +12 more
semanticscholar   +1 more source

Unicuspid Aortic Stenosis in a Patient with Turner Syndrome: A Case Report

Frontiers in Cardiovascular Medicine, 2014
Congenital aortic valve anomalies are the cause of premature aortic stenosis in pediatric and younger adult populations. Despite being very rare, unicuspid aortic valves account for approximately 5% of isolated aortic valve replacements.
Michael eEssandoh, Karina eCastellon-Larios, Alix eZuleta-Alarcon, Juan Guillermo Portillo, Juan A Crestanello   +4 more
doaj   +1 more source

Anticoagulation intensity and outcomes among southeast‐Asians with moderate‐to‐severe mitral valve stenosis

British Journal of Clinical Pharmacology, EarlyView.
Objective To determine the optimal anticoagulation intensity of warfarin in a South‐East Asian population with moderate‐to‐severe rheumatic mitral stenosis. Methods A multicentre, retrospective study examined patients with rheumatic mitral stenosis who had not undergone valve replacement or repair and required long‐term warfarin therapy at two ...
Punyawee Puchsaka, Wipharak Rattanavipanon, Sararat Phetroong, Rudeekorn Ue‐sethasakdhi, Suparat Wattanasombat, Wattana Wongtheptien, Surakit Nathisuwan   +6 more
wiley   +1 more source

C-reactive protein in degenerative aortic valve stenosis

Cardiovascular Ultrasound, 2006
Degenerative aortic valve stenosis includes a range of disorder severity from mild leaflet thickening without valve obstruction, "aortic sclerosis", to severe calcified aortic stenosis.
Mazzone AnnaMaria, Sanchez Pedro L
doaj   +1 more source

Management of hypotension in dihydropyridine calcium channel blocker overdose: The role of high‐dose insulin therapy

British Journal of Clinical Pharmacology, EarlyView.
Aims Amlodipine poisoning is a leading cause of cardiovascular medication‐related deaths, commonly managed with high‐dose insulin (HDI) therapy. However, HDI is a vasodilator that is counterproductive in managing vasoplegia. We aim to study HDI therapy in patients with hypotension following dihydropyridine calcium channel antagonist (CCA) overdose ...
Betty S. H. Chan, Katherine Z. Isoardi, Darren M. Roberts, Ong Sook Har   +3 more
wiley   +1 more source