Results 81 to 90 of about 406,657 (306)

Genetic Polymorphisms, Plasma Levels of Lipoprotein (A) and its Possible Links with Degenerative Aortic Stenosis [PDF]

Journal of Biomedical & Clinical Research, 2016
Degenerative aortic stenosis is the second most common acquired valvular heart disease in adults (after mitral insufficiency) and the second most common cause for cardiac surgery (after coronary heart disease).
Vesela Tomova, Tihomir Rashev, Milena Atanasova   +2 more
doaj   +3 more sources

Early intervention or watchful waiting for asymptomatic severe aortic valve stenosis: a systematic review and meta-analysis.

, 2020
BACKGROUND: The management of patients with severe but asymptomatic aortic stenosis is challenging. Evidence on early aortic valve replacement (AVR) versus symptom-driven intervention in these patients is unknown.

core   +1 more source

Model validation for a noninvasive arterial stenosis detection problem [PDF]

, 2014
Copyright @ 2013 American Institute of Mathematical SciencesA current thrust in medical research is the development of a non-invasive method for detection, localization, and characterization of an arterial stenosis (a blockage or partial blockage in an ...
Kenz, Z, Banks, HT, Birch, MJ, Kruse, C, Brewin, MP, Greenwald, SE, Whiteman, JR, Hu, S, Shaw, S   +8 more
core   +1 more source

Longitudinal Echocardiographic Surveillance of Aortic Dilation in a Phenotype‐Enriched Turner Syndrome Cohort

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Turner syndrome (TS) is associated with thoracic aortopathy and increased risk for aortic dissection, yet the natural history of aortic dilation is not well understood. We performed a retrospective longitudinal study of individuals with TS who participated in the TS Society of the United States Healthy Heart Project between 2003 and 2023 ...
Dylan Doerner, Matthew R. Johnson, Sara Mansoorshahi, Rakesh Kathiresan, Katelyn Abel, Jonathan G. You, Emilio Quezada, Siddharth K. Prakash   +7 more
wiley   +1 more source

Emergency treatment of acute decompensated critical aortic stenosis with transcatheter aortic valve implantation

, 2020
Transcatheter aortic valve implantation (TAVI) is relatively contraindicated in the bicuspid aortic valve, and to our knowledge has not been tried where the true native annulus is of a size far in excess of current device capabilities.
Singh, Kuljit, Win, Kyi TH, Camuglia, Anthony, Provenzano, Sylvio   +3 more
core   +1 more source

Spectrum of Congenital Anomalies in Myhre Syndrome—Insights Into Effects Brought by Altered TGF‐β Signaling via Gain‐of‐Function Variants in SMAD4

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome is a rare genetic disorder characterized by progressive multisystem involvement. Gain‐of‐function missense heterozygous variants affecting the Ile500 residue and Arg496 residue of the SMAD4 gene are implicated in this condition.
Kawmadi Gunawardena, Alessandro De Falco, Deborah Osio, Eleanor Sherlock, Emma Kivuva, Erina Sasaki, Francis H. Sansbury, Nayana Lahiri, Patricia Foley, Sahar Mansour, Shane McKee, Tazeen Ashraf, Nicola Brunetti‐Pierri, Usha Kini   +13 more
wiley   +1 more source

Neonatal aortic stenosis

The Journal of Thoracic and Cardiovascular Surgery, 1990
Aortic stenosis in the neonate has been associated in the past with a high operative mortality. As a result, in the current era of percutaneous balloon dilatation, the optimal mode of therapy remains controversial. An approach of stabilization with cardiopulmonary bypass, followed by relief of left ventricular outflow tract obstruction, was used at ...
K, Turley, E L, Bove, J J, Amato, M, Iannettoni, J, Yeh, J V, Cotroneo, R J, Galdieri   +6 more
openaire   +2 more sources

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Assessment and risk prediction in patients with aortic stenosis: insights from cardiovascular magnetic resonance [PDF]

, 2015
BACKGROUND Aortic stenosis affects not only the valve but also the myocardium. In response to the increased afterload, left ventricular hypertrophy initially occurs as a compensatory response to maintain wall stress and cardiac output but ultimately,
Chin, Calvin Woon Loong
core   +3 more sources

Valvular Aortic Stenosis: A Proteomic Insight

, 2010
Calcified aortic valve disease is a slowly progressive disorder that ranges from mild valve thickening with no obstruction of blood flow, known as aortic sclerosis, to severe calcification with impaired leaflet motion or aortic stenosis.
Lopez-Almodovar, Luis, Cuesta, Fernando de La, Fernando Vivanco, Martin-Rojas, Tatiana, Luis F. Lopez-Almodovar, Tatiana Martin-Rojas, Darde, Veronica, Barderas, Maria, Fernando de la Cuesta, Barroso, Gemma, Maria G. Barderas, Veronica M. Darde, Luis R. Padial, Gemma Barroso, Gloria Alvarez-Llamas, Gil Dones, Félix, Vivanco, Fernando, Felix Gil-Dones, Juarez-Tosina, Rocio, Padial, Luis, Álvarez Llamas, Gloria, Rocio Juarez-Tosina   +21 more
core   +1 more source