Results 61 to 70 of about 133,767 (311)

Lipoprotein(a) in patients with aortic stenosis: Insights from cardiovascular magnetic resonance.

PLoS ONE, 2017
BackgroundAortic stenosis is the most common age-related valvular pathology. Patients with aortic stenosis and myocardial fibrosis have worse outcome but the underlying mechanism is unclear.
Vassilios S Vassiliou, Paul D Flynn, Claire E Raphael, Simon Newsome, Tina Khan, Aamir Ali, Brian Halliday, Annina Studer Bruengger, Tamir Malley, Pranev Sharma, Subothini Selvendran, Nikhil Aggarwal, Anita Sri, Helen Berry, Jackie Donovan, Willis Lam, Dominique Auger, Stuart A Cook, Dudley J Pennell, Sanjay K Prasad   +19 more
doaj   +1 more source

Misconceptions and Facts About Aortic Stenosis. [PDF]

, 2017
Aortic stenosis is the most common valvular heart disease leading to intervention, and it is typically a disease of the elderly. Recent clinical advances have expanded the role of transcatheter aortic valve intervention in patients with severe aortic ...
Windecker, Stephan, Argulian, Edgar, Messerli, Franz H   +2 more
core   +1 more source

Clinical and Laboratory Characterization of Acquired Von Willebrand Syndrome

American Journal of Hematology, EarlyView.
ABSTRACT Acquired von Willebrand Syndrome (AVWS) is a rare bleeding disorder characterized by quantitative or qualitative defects of von Willebrand factor (VWF) in patients without a personal or family history of bleeding. It is frequently associated with systemic diseases, particularly lymphoproliferative disorders (LPDs) and myeloproliferative ...
Alessandro Ciavarella, Luciano Baronciani, Omid Seidizadeh, Paola Colpani, Elio Ingenito, Daniele Cattaneo, Maria Teresa Pagliari, Addolorata Truma, Alessandra Iurlo, Simona Maria Siboni, Flora Peyvandi   +10 more
wiley   +1 more source

Williams-Beuren syndrome: cardiovascular abnormalities in 20 patients diagnosed with fluorescence in situ hybridization

Arquivos Brasileiros de Cardiologia, 2003
OBJECTIVE: To evaluate the cardiovascular findings and clinical follow-up of patients with Williams-Beuren syndrome. METHODS: We studied 20 patients (11 males, mean age at diagnosis: 5.9 years old), assessed for cardiovascular abnormalities with ...
Sofia Mizuho Miura Sugayama, Regina Lúcia Moisés, Jaqueline Wagënfur, Nana Miura Ikari, Kikue Terada Abe, Cláudio Leone, Clóvis Artur Almeida da Silva, Maria de Lourdes Lopes Ferrari Chauffaille, Ae Kim Chong   +8 more
doaj   +1 more source

Model validation for a noninvasive arterial stenosis detection problem [PDF]

, 2014
Copyright @ 2013 American Institute of Mathematical SciencesA current thrust in medical research is the development of a non-invasive method for detection, localization, and characterization of an arterial stenosis (a blockage or partial blockage in an ...
Kenz, Z, Banks, HT, Birch, MJ, Kruse, C, Brewin, MP, Greenwald, SE, Whiteman, JR, Hu, S, Shaw, S   +8 more
core   +1 more source

Perspective Chapter: Lipoprotein (a), Cardiac Amyloidosis, and Aortic Stenosis - Underestimated Associations [PDF]

, 2022
This chapter aims to address two peculiar aspects of pathophysiology and clinical management of aortic valve stenosis, such as coexistence with cardiac amyloidosis and association with lipoprotein (a).
Nicola Bernardi, Pompilio Faggiano, Gloria Santangelo, Andrea Bonelli, Andrea Faggiano, Stefano Carugo, Filippo Toriello   +6 more
core   +1 more source

Spectrum of Congenital Anomalies in Myhre Syndrome—Insights Into Effects Brought by Altered TGF‐β Signaling via Gain‐of‐Function Variants in SMAD4

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome is a rare genetic disorder characterized by progressive multisystem involvement. Gain‐of‐function missense heterozygous variants affecting the Ile500 residue and Arg496 residue of the SMAD4 gene are implicated in this condition.
Kawmadi Gunawardena, Alessandro De Falco, Deborah Osio, Eleanor Sherlock, Emma Kivuva, Erina Sasaki, Francis H. Sansbury, Nayana Lahiri, Patricia Foley, Sahar Mansour, Shane McKee, Tazeen Ashraf, Nicola Brunetti‐Pierri, Usha Kini   +13 more
wiley   +1 more source

Successful percutaneous balloon dilatation of supravalvular aortic membrane

Heart Views, 2019
Supravalvular aortic stenosis is the least common type of left ventricular outflow tract obstruction. Primary balloon dilatation of membranous supravalvular aortic stenosis was performed in a 10-year-old male child with a remarkable reduction in systolic
Gurkirat Singh, Hemant Khemani, Rahul Singla, Narender Omprakash Bansal   +3 more
doaj   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Myocardial extracellular volume quantification by computed tomography predicts outcomes in patients with severe aortic stenosis.

PLoS ONE, 2021
BackgroundThe extent of myocardial fibrosis in patients with severe aortic stenosis might have an important prognostic value. Non-invasive imaging to quantify myocardial fibrosis by measuring extracellular volume fraction might have an important clinical
Yoav Hammer, Yeela Talmor-Barkan, Aryeh Abelow, Katia Orvin, Yaron Aviv, Noam Bar, Amos Levi, Uri Landes, Gideon Shafir, Alon Barsheshet, Hana Vaknin-Assa, Alexander Sagie, Ran Kornowski, Ashraf Hamdan   +13 more
doaj   +1 more source