Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis.
New England Journal of Medicine, 2020 BACKGROUND The timing and indications for surgical intervention in asymptomatic patients with severe aortic stenosis remain controversial. METHODS In a multicenter trial, we randomly assigned 145 asymptomatic patients with very severe aortic stenosis ...
D. Kang +12 more
semanticscholar +3 more sources
Cardiac amyloidosis and aortic stenosis: a state-of-the-art review
European Heart Journal Open, 2023 Cardiac amyloidosis is caused by the extracellular deposition of amyloid fibrils in the heart, involving not only the myocardium but also any cardiovascular structure.
Vikash Jaiswal +14 more
semanticscholar +1 more source
Multi-Modality Imaging in Aortic Stenosis an EACVI Clinical Consensus Document.
European Heart Journal-Cardiovascular Imaging, 2023 In this EACVI clinical scientific update, we will explore the current use of multi-modality imaging in the diagnosis, risk-stratification and follow-up of patients with aortic stenosis, with a particular focus on recent developments and future directions.
M. Dweck +16 more
semanticscholar +1 more source
Circulation, 2021 Background: Surgical aortic valve replacement (SAVR) represents a class I indication in symptomatic patients with severe aortic stenosis (AS). However, indications for early SAVR in asymptomatic patients with severe AS and normal left ventricular ...
M. Banovic +16 more
semanticscholar +1 more source
Journal of the American Medical Association (JAMA), 2021 Importance There are limited data on outcomes of transcatheter aortic valve replacement (TAVR) for bicuspid aortic stenosis in patients at low surgical risk.
R. Makkar +16 more
semanticscholar +1 more source
A model based on clinical parameters to identify myocardial late gadolinium enhancement by magnetic resonance in patients with aortic stenosis: An observational study [PDF]
, 2020 Objective With increasing age, the prevalence of aortic stenosis grows exponentially, increasing left heart pressures and potentially leading to myocardial hypertrophy, myocardial fibrosis and adverse outcomes.
Alpendurada, Francisco +6 more
core +1 more source
Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis
Circulation, 2021 Supplemental Digital Content is available in the text. Background: Valvular calcification is central to the pathogenesis and progression of aortic stenosis, with preclinical and observational studies suggesting that bone turnover and osteoblastic ...
T. Pawade +22 more
semanticscholar +1 more source
Pathological Investigation of Congenital Bicuspid Aortic Valve Stenosis, Compared with Atherosclerotic Tricuspid Aortic Valve Stenosis and Congenital Bicuspid Aortic Valve Regurgitation [PDF]
, 2016 Congenital bicuspid aortic valve (CBAV) is the main cause of aortic stenosis (AS) in young adults. However, the histopathological features of AS in patients with CBAV have not been fully investigated.We examined specimens of aortic valve leaflets ...
A Mazzone +40 more
core +7 more sources
Contrast-enhanced computed tomography assessment of aortic stenosis
Heart, 2021 Objectives Non-contrast CT aortic valve calcium scoring ignores the contribution of valvular fibrosis in aortic stenosis. We assessed aortic valve calcific and non-calcific disease using contrast-enhanced CT.
T. Cartlidge +17 more
semanticscholar +1 more source
Current Therapeutic Options in Aortic Stenosis.
Circulation Research, 2021 Aortic stenosis is the most common valvular disease requiring valve replacement. Valve replacement therapies have undergone progressive evolution since the 1960s.
Marko T. Boskovski, T. Gleason
semanticscholar +1 more source