Results 91 to 100 of about 41,911 (295)

The focal adhesion: a regulated component of aortic stiffness. [PDF]

PLoS ONE, 2013
Increased aortic stiffness is an acknowledged predictor and cause of cardiovascular disease. The sources and mechanisms of vascular stiffness are not well understood, although the extracellular matrix (ECM) has been assumed to be a major component.
Robert J Saphirstein, Yuan Z Gao, Mikkel H Jensen, Cynthia M Gallant, Susanne Vetterkind, Jeffrey R Moore, Kathleen G Morgan   +6 more
doaj   +1 more source

Structure-function relationships in the aortic valve [PDF]

, 2012
PhDGlobally, heart valve dysfunction constitutes a large portion of the cardiovascular disease load, causing high rates of mortality in European and industrialized countries.
Anssari-Benam, Afshin
core  

Spectrum of Congenital Anomalies in Myhre Syndrome—Insights Into Effects Brought by Altered TGF‐β Signaling via Gain‐of‐Function Variants in SMAD4

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome is a rare genetic disorder characterized by progressive multisystem involvement. Gain‐of‐function missense heterozygous variants affecting the Ile500 residue and Arg496 residue of the SMAD4 gene are implicated in this condition.
Kawmadi Gunawardena, Alessandro De Falco, Deborah Osio, Eleanor Sherlock, Emma Kivuva, Erina Sasaki, Francis H. Sansbury, Nayana Lahiri, Patricia Foley, Sahar Mansour, Shane McKee, Tazeen Ashraf, Nicola Brunetti‐Pierri, Usha Kini   +13 more
wiley   +1 more source

P6.07 A STUDY TO DETERMINE IF THE REFLECTED WAVE TRANSIT TIME FROM BRACHIAL SUPRASYSTOLIC WAVEFORM ANALYSIS IS REPRESENTATIVE OF LARGE ARTERY STIFFNESS

Artery Research, 2013
Background: Aortic stiffness is clinically important, but measurement can be time consuming. The ‘reflected wave transit time’ (RWTT) is thought to represent aortic stiffness and, since this can be measured quickly by brachial cuff oscillometry, could be
M. Eskandari, R.E.D. Climie, S.B. Nikolic, J.E. Sharman   +3 more
doaj   +1 more source

Aortic stiffness in lone atrial fibrillation: a novel risk factor for arrhythmia recurrence. [PDF]

PLoS ONE, 2013
BackgroundRecent community-based research has linked aortic stiffness to the development of atrial fibrillation. We posit that aortic stiffness contributes to adverse atrial remodeling leading to the persistence of atrial fibrillation following catheter ...
Dennis H Lau, Melissa E Middeldorp, Anthony G Brooks, Anand N Ganesan, Kurt C Roberts-Thomson, Martin K Stiles, Darryl P Leong, Hany S Abed, Han S Lim, Christopher X Wong, Scott R Willoughby, Glenn D Young, Jonathan M Kalman, Walter P Abhayaratna, Prashanthan Sanders   +14 more
doaj   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Review of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (MS) is a connective‐tissue disorder within the acromelic dysplasia spectrum. It is characterized by congenital craniofacial, skeletal, cutaneous anomalies, respiratory, cardiovascular along with intellectual disability, deafness, and progressive fibrosis.
Camille Viaut, Valerie Cormier‐Daire
wiley   +1 more source

Cardiovascular aging: Insights from local and regional measures of aortic stiffness using magnetic resonance imaging

Artery Research, 2014
Aortic stiffness is now established as an independent marker of cardiovascular aging and cardiovascular risk. However, the specific role of the proximal aorta, specifically the ascending aorta, remains understudied.
Alban Redheuil
doaj   +1 more source

Aortic stiffness index and diurnal variability (dipper/non-dipper) in hypertensive patients Aortic stiffness and hypertension

, 2018
Aim: Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients. In this study, we aimed to evaluate how aortic elasticity parameters [aortic distensibility (AD), aortic stiffness index (ASI), aortic strain (AS)] is ...
Ertem, Ahmet Göktuğ, Köseoğlu, Cemal, Aslan, Turgay, Efe, Tolga Han, Erdoğan, Mehmet, Kurmuş, Özge, Bilge, Mehmet   +6 more
core   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source