Results 81 to 90 of about 41,911 (295)

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Thoracic Aortic Aneurysm Growth in Bicuspid Aortic Valve Patients: Role of Aortic Stiffness and Pulsatile Hemodynamics

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Bicuspid aortic valve (BAV) is the most common congenital cardiac abnormality. A thoracic aortic aneurysm (TAA) is present in ≈50% of BAV patients, who also have an 8‐fold higher risk of aortic dissection than the general population.
Jasjit Rooprai, Munir Boodhwani, Luc Beauchesne, Kwan‐Leung Chan, Carole Dennie, Sudhir Nagpal, David Messika‐Zeitoun, Thais Coutinho   +7 more
doaj   +1 more source

Mechanisms and Subclinical Consequences of Aortic Stiffness [PDF]

Hypertension, 2017
The number of published articles on PubMed with arterial stiffness or aortic stiffness in the title during the past 20 years exceeds 4000 articles published, with more than one-half published in the past 5 years (see Figure). The studies published on the topic of arterial stiffness span the full translational continuum from basic mechanistic studies in
openaire   +2 more sources

Generation of Self‐Organizing Macrovascular Constructs by Bioprinting Human iPSC‐Derived Mesodermal Progenitor Cells

Advanced Science, EarlyView.
ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan, Nathaly A. Chicaiza‐Cabezas, Florian Kleefeldt, Philipp Wörsdörfer, Jürgen Groll, Süleyman Ergün   +5 more
wiley   +1 more source

Aortic stiffness in normal and hypertensive pregnancy

Blood Pressure, 2009
The objective of this study was to examine whether aortic stiffness, as assessed by pulse wave analysis, could reliably discriminate between normal and hypertensive pregnancies. One hundred pregnant women were studied: five with severe pre-eclampsia, 27 with gestational hypertension, 14 with chronic hypertension and 54 with normal pregnancy.
B, Avni, G, Frenkel, L, Shahar, A, Golik, D, Sherman, V, Dishy   +5 more
openaire   +2 more sources

A Steerable and Expandable Magnetic Aspiration Catheter for Enhanced Aspiration Thrombectomy

Advanced Intelligent Systems, EarlyView.
This article presents a novel magnetic aspiration catheter (MAC) that can be both actively steered and undergo distal‐end expansion via externally applied magnetic fields. The MAC facilitates precise branch selection and enhances clot engagement by improving endovascular navigation and aspiration efficiency. Phantom experiments validate its feasibility
Hakjoon Lee, Xiao Dong, Dong‐in Kim, A. M. Masum Bulbul Chowdhury, Nader Latifi Gharamaleki, Jin‐young Kim, Sung Won Youn, Hongsoo Choi   +7 more
wiley   +1 more source

Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension

Cellular Physiology and Biochemistry, 2017
Background/Aims: Our previous studies demonstrated that intrinsic aortic smooth muscle cell (VSMC) stiffening plays a pivotal role in aortic stiffening in aging and hypertension. However, the underlying molecular mechanisms remain largely unknown.
Ning Zhou, Jia-Jye Lee, Shaunrick Stoll, Ben Ma, Kevin D. Costa, Hongyu Qiu   +5 more
doaj   +1 more source

Drug therapies and presence of coronary artery disease may affect aortic stiffness in Alzheimer’s disease

, 2015
Osman Bektaş,1 Zeki Yüksel Günaydin,1 Ahmet Karagöz,2 Ahmet Kaya1 1Ordu University, Department of Cardiology, Ordu, 2Giresun University, Department of Cardiology, Giresun, TurkeyWe have read the original research entitled "Altered ...
Kaya, Ahmet, Bektaş O, Kaya A, Karagöz, Ahmet, Günaydın ZY, Günayd n, Zeki Yüksel, Bekta , Osman, Karagöz A   +7 more
core   +1 more source

Pre‐Curved Everting Robots With Embedded Steering Intelligence Fabricated by CO2 Laser Welding

Advanced Intelligent Systems, EarlyView.
Design and experimental demonstration of a laser welded growing robot for anatomically guided navigation. The robot follows an aortic arch phantom entering the branchiocephalic branch through steering by design. The figure shows the physical phantom setup, CAD defined weld geometry and full robot eversion.
Brandon Saldarriaga, Panagiotis Kalozoumis, Panagiotis Vartholomeos, Carlo Seneci, Kawal Rhode, Christos Bergeles   +5 more
wiley   +1 more source

Aortic Wall Elastic Properties in Case of Bicuspid Aortic Valve

Frontiers in Physiology, 2019
Purpose of the ReviewBicuspid aortic valve (BAV) is associated with a significant risk of development of aneurysm and dissection of the ascending thoracic aorta.
Guillaume Goudot, Tristan Mirault, Tristan Mirault, Patrick Bruneval, Patrick Bruneval, Gilles Soulat, Mathieu Pernot, Emmanuel Messas, Emmanuel Messas   +8 more
doaj   +1 more source