Results 101 to 110 of about 1,753,663 (307)

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Preemptive treatment in the acute and early subacute phase of uncomplicated type B aortic dissections with poor prognosis factors

Frontiers in Cardiovascular Medicine
ObjectiveDue to its favorable outcome regarding late morbidity and mortality, thoracic endovascular repair (TEVAR) is becoming more popular for uncomplicated type B aortic dissection (TBAD).
Charlotte Sachs, Charlotte Sachs, Fabien Vecchini, Fabien Vecchini, Marie Corniquet, Michel Bartoli, Pierre-Antoine Barral, Mariangela De Masi, Mariangela De Masi, Virgile Omnes, Virgile Omnes, Philippe Piquet, Philippe Piquet, Jean-Marc Alsac, Marine Gaudry, Marine Gaudry   +15 more
doaj   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Elective Open Suprarenal Aneurysm Repair in England from 2000 to 2010 an Observational Study of Hospital Episode Statistics [PDF]

, 2013
Background: Open surgery is widely used as a benchmark for the results of fenestrated endovascular repair of complex abdominal aortic aneurysms (AAA).
Hinchliffe, RJ, Jan D Poloniecki, Thompson, MM, Holt Peter J. E., Sollazzo Giuseppe, Hinchliffe Robert J., Alan Karthikesalingam, Robert J Hinchliffe, Matthew M Thompson, Peter J E Holt, Poloniecki, JD, Karthikesalingam, A, Patterson Benjamin O., Thompson Matthew M., Benjamin O Patterson, Giuseppe Sollazzo, Holt, PJ, Vidal-Diez, A, Sollazzo, G, Vidal-Diez Alberto, Karthikesalingam Alan, Patterson, BO, Alberto Vidal-Diez, Poloniecki Jan D.   +23 more
core   +1 more source

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

Retrograde conduit-assisted hybrid repair for tandem common carotid and subclavian lesions

Annals of Vascular Surgery - Brief Reports and Innovations
Background: Tandem occlusive disease involving both the common carotid artery (CCA) and subclavian artery (SCA) presents a unique technical challenge. Open bypass procedures remain durable but carry significant morbidity, particularly in patients with ...
Marisa Doran, Carter Colwell, Mamata Tokala, Daniel Zumsteg, Esmaeel Dadashzadeh, Joshua Adams   +5 more
doaj   +1 more source

Cerebral protection during surgery of the aortic arch

, 2010
Brain injury represents a primary concern during aortic valve surgery. Valid surgical techniques and reliable methods of brain protection are required to obtain a favorable outcome after such a complex surgery.
SAVINI, CARLO, DI BARTOLOMEO, ROBERTO, PACINI, DAVIDE, DI EUSANIO, MARCO, Pilato E   +4 more
core   +1 more source

Extracellular matrix composition and remodeling in human abdominal aortic aneurysms: a proteomics approach. [PDF]

, 2011
Abdominal aortic aneurysms (AAA) are characterized by pathological remodeling of the aortic extracellular matrix (ECM). However, besides the well-characterized elastolysis and collagenolysis little is known about changes in other ECM proteins.
Mandal, K, Marjan Jahangiri, Didangelos, Athanasios, Didangelos, A, Smith, A, Mandal, Kaushik, Saje, A, Smith, Alberto, Xu, Q, Jahangiri, M, Mayr, Manuel; id_orcid, Mayr, M, Athanasios Didangelos, Alberto Smith, Qingbo Xu, Jahangiri, Marjan, Kaushik Mandal, Angelika Saje, Saje, Angelika, Yin, Xiaoke; id_orcid, Xu, Qingbo, Xiaoke Yin, Manuel Mayr, Yin, X   +23 more
core   +1 more source

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

Advanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang, Yuping Zhang, Xiaoning Su, Ning Liu, Hui Zeng, Bo Yang, Yang Xue, Fang Guo, Changkui Liu   +8 more
wiley   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source