Results 81 to 90 of about 1,753,663 (307)

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Standards of reporting in open and endovascular aortic surgery (STORAGE guidelines). [PDF]

, 2019
The number of patients undergoing surgery on the thoracic and thoraco-abdominal aorta has been steadily increasing over the past decade. This document aims to give guidance to authors reporting on results in aortic surgery by clarifying definitions of ...
Tsagakis, K, De Paulis, R, Roselli, Eric E, Rylski, B, Pacini, Davide, Schachner, T, Durko, Andras, Carrel, T, Schachner, Thomas, Carrel, Thierry, Siepe, Matthias, Carrel, Thierry P., Siepe, M, Roselli, EE, Ronchey, Sonia, Beyersdorf, F, De Paulis, Ruggero, Czerny, Martin, Tsagakis, Konstantinos, Schönhoff, Florian, Beyersdorf, Friedhelm, Ronchey, S, Schoenhoff, FS, Pacini, D, Czerny, M, Rylski, Bartosz, Quintana, E, Quintana, Eduard   +27 more
core   +2 more sources

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

Advanced Science, EarlyView.
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang, Ziyang Tong, Chunmei Fan, Silong Chen, Jiarui Guo, Jianghua Hu, Ke Yao, Zi Yin, Xiao Chen, Yibo Yu   +9 more
wiley   +1 more source

The Future of Aortic Surgery.

Portuguese journal of cardiac thoracic and vascular surgery
Portuguese Journal of Cardiac Thoracic and Vascular Surgery, Vol. 31 No.
openaire   +2 more sources

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

The Fate of Bronchial Artery Aneurysm over the Last 25 Years: A Systematic Review and Pooled Analysis

Journal of Vascular Diseases
Purpose: Bronchial artery aneurysms (BAA) and pseudoaneurysms (BAP) are uncommon vascular lesions that may present incidentally with hemoptysis or following rupture.
Konstantinos-E. Koumarelas, Platon-M. Dimopoulos, Konstantinos Kotopoulos, Leszek Kukulski, Dimitrios-D. Papazoglou, Vaiva Dabravolskaite, Thomas R. Wyss, Drosos Kotelis, Vladimir Makaloski   +8 more
doaj   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Prospective analysis of metabolic syndrome and inflammation in aortic aneurysm risk: UK Biobank study

Frontiers in Endocrinology
Context/ObjectivesMetabolic syndrome (MetS) is associated with various diseases, yet its connection with aortic aneurysm (AA) is not well understood. The role of chronic inflammation as a mediator in this relationship also remains unclear.
Xinyi Liu, Hao Liu, Suwei Chen, Chen Gong, Yipeng Ge, Zhiyu Qiao, Chengnan Li, Junming Zhu   +7 more
doaj   +1 more source

Acute type B aortic dissection in the absence of aortic dilatation [PDF]

, 2012
BackgroundIncreasing aortic diameter is thought to be an important risk factor for acute type B aortic dissection (ABAD). However, some patients develop ABAD in the absence of aortic dilatation. In this report, we sought to characterize ABAD patients who
J. B. Froehlich, Iternational Registry of Acute Aortic Dissection investigators, Rampoldi, Vincenzo, B. E. Muhs, Jonker, Frederik H.W., Muhs, Bart E., Trimarchi, Santi, Eagle, Kim A., F. L. Moll, K. A. Eagle, G. R. Upchurch, H. J. Patel, V. Rampoldi, Patel, Himanshu J., Froehlich, James B., S. Trimarchi, F. H. W. Jonker, Upchurch, Gilbert R., Moll, Frans L.   +18 more
core   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source