Results 71 to 80 of about 1,753,663 (307)

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

A novel all-retrograde approach for t-Branch implantation in ruptured thoracoabdominal aneurysm

Journal of Vascular Surgery Cases and Innovative Techniques, 2018
The off-the-shelf t-Branch device (Cook Medical, Bloomington, Ind) significantly advanced the endovascular treatment of ruptured thoracoabdominal aortic aneurysms.
A. Claire Watkins, MD, MS, Alla Avramenko, MD, Raphael Soler, MD, Dominique Fabre, MD, PhD, Stephan Haulon, MD, PhD   +4 more
doaj   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Paraplegia following aortic surgery [PDF]

Spinal Cord, 1982
It has long been recognised that paraplegia may occur after various surgical procedures on the heart and the aorta. Paraplegia occurring following traumatic rupture of the aorta has not been commonly reported due to the dismal prognosis of such rupture. Over the past 3 years, we have encountered five patients who survived traumatic rupture of the aorta
C, Lynch, S I, Weingarden
openaire   +2 more sources

Classical supravalvar aortic stenosis and peripheral pulmonary stenosis [PDF]

, 2014
Supravalvar aortic stenosis as well as peripheral pulmonary stenosis are rare forms of congenital heart disease, which occur, however, relatively frequently in association.
Ramakrishnan, S., Gupta, S.K., Kahr, P.C., Kothari, Shyam S.   +3 more
core  

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

Advanced Science, EarlyView.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang, Zhehao Lin, Lu Chen, Ying Ni, Jun Zhou, Wenjuan Zhang, Huilin Wang, Peifeng Ying, Xiu Lu, Kai Wang, Qingran Kong, Naxin Xu, Dingsheng Zhao, Jianwei Li, Guohui Zhong, Xingchen Meng, Sarkawt Hamad, Junmeng Zheng, Yuan Fu, Rongjiang Qin, Xuran Chu, Shangxuan Li, Youyou Li, Yili Wu, Yi Wang, Weihong Song, Yingxian Li, Shukuan Ling   +27 more
wiley   +1 more source

Accelerated biological aging, genetic susceptibility, and lifestyle in relation to abdominal aortic aneurysm: A prospective study

The Journal of Nutrition, Health and Aging
Objectives: This study aimed to investigate the associations of biological age (BA) acceleration and genetic risk with the incidence of abdominal aortic aneurysm (AAA), and to evaluate the extent to which BA acceleration mediates the impact of a healthy ...
Xinyi Liu, Yongliang Zhong, Suwei Chen, Chengnan Li, Yipeng Ge, Haiou Hu, Junming Zhu   +6 more
doaj   +1 more source

Standardizing clinical end points in aortic arch surgery: a consensus statement from the International Aortic Arch Surgery Study Group.

, 2014
Since the introduction of hypothermic circulatory arrest for aortic arch surgery in 1975,1 there has been considerable progress in addressing this complex surgical pathology.2–4 However, the rapidity with which operative techniques have evolved has ...
Yan TD, Tian DH, Oo A, Hughes GC, Chen EP, Underwood MJ, Kazui T, Griepp RB, Coselli JS, Mohr FW, Lemaire SA, Elefteriades JA, Mathew JP, Kouchoukos NT, Misfeld M, DI BARTOLOMEO, ROBERTO, Bavaria JE, DI EUSANIO, MARCO, Sundt TM, Trimarchi S, Bannon PG, International Aortic Arch Surgery Study Group   +21 more
core   +1 more source

Bioinspired Passive Flow Routing to Mitigate Thrombosis in Prosthetic Heart Valves and Cardiovascular Devices

Advanced Science, EarlyView.
Bioinspired passive flow routing mitigates thrombosis in cardiovascular devices by redirecting a small fraction of forward flow into stagnation‐prone regions. Inspired by avian alula and aircraft slat mechanisms, strategically placed routing channels restore washout around mechanical heart valves, reducing low‐shear exposure by four orders of magnitude
Yevgeniy Kreinin, Mark Epshtein, Yahel Talmon, Tirosh Mekler, Itay Or, Mahli Raad, Gil Bolotin, Josué Sznitman, Netanel Korin   +8 more
wiley   +1 more source

Retrograde Cerebral Perfusion with Hypothermic Circulatory Arrest in Aortic Arch Surgery : Operative and Long-Term Results [PDF]

, 2001
2001-11Methods: Clinical data were retrospectively collected for 207 consecutive patients who underwent aortic arch surgery using continuous retrograde cerebral perfusion (CRCP) and hypothermic circulatory arrest (HCA) at Tenri Hospital (138 patients ...
Ueda, Yuichi
core   +1 more source