Results 161 to 170 of about 1,048,768 (410)

Role of p38 MAPK in Atherosclerosis and Aortic Valve Sclerosis

International Journal of Molecular Sciences, 2018
Atherosclerosis and aortic valve sclerosis are cardiovascular diseases with an increasing prevalence in western societies. Statins are widely applied in atherosclerosis therapy, whereas no pharmacological interventions are available for the treatment of ...
A. Reustle, M. Torzewski
semanticscholar   +1 more source

Tall Stature and Scoliosis Associated With a Novel Homozygous Loss‐of‐Function Missense Variant in NPR3

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT NPR3‐related tall stature is characterized by tall stature, elongated big toes, and additional epiphyses in hand and foot bones. The condition is caused by biallelic loss‐of‐function variants affecting natriuretic peptide receptor 3 (NPR3). Five individuals from four different families have been reported.
Pierre Moffatt, Chantal Janelle, Valancy Miranda, Ghalib Bardai, Frank Rauch   +4 more
wiley   +1 more source

Preoperative aortic root geometry and postoperative cusp configuration primarily determine long-term outcome after valve-preserving aortic root repair [PDF]

, 2012
ObjectiveTechnical controversies exist in valve-preserving aortic root replacement. We sought to determine predictors of long-term stability of the aortic valve.MethodsA total of 430 patients (aged 57 ± 15 years, 323 male) underwent valve-preserving ...
Aicher, Diana, Groesdonk, Heinrich-Volker, Kunihara, Takashi, Langer, Frank, Rodionycheva, Svetlana, Sata, Fumihiro, Schäfers, Hans-Joachim   +6 more
core   +1 more source

Potential Causality and Emerging Medical Therapies for Lipoprotein(a) and Its Associated Oxidized Phospholipids in Calcific Aortic Valve Stenosis.

Circulation Research, 2019
The prevalence of calcific aortic valve disease is increasing with aging of the population. Current treatment options for advanced or symptomatic aortic stenosis are limited to traditional surgical or percutaneous aortic valve replacement.
S. Tsimikas
semanticscholar   +1 more source

The Influence of the Aortic Root Geometry on Flow Characteristics of a Bileaflet Mechanical Heart Valve [PDF]

arXiv, 2018
Bileaflet mechanical heart valves have one of the most successful valve designs for more than 30 years. These valves are often used for aortic valve replacement, where the geometry of the aortic root sinuses may vary due to valvular disease and affect valve performance. Common geometrical sinus changes may be due to valve stenosis and insufficiency. In
arxiv  

Myxomatous degeneration of aortic valve causing severe aortic regurgitation. A rare case report

SAGE Open Medical Case Reports
Myxomatous degeneration of a valve is a non-inflammatory degenerative process due to the disruption of the fibrous layer of the valve with mucopolysaccharide accumulation. It is mostly seen in the mitral valve but involvement in only aortic valve is rare.
Rakesh Kumar Kodakkandla, Venkata Sreedatta Sarraju, Nagesh Ayalasomayajula   +2 more
doaj   +1 more source

Central aortic valve coaptation area during diastole as seen by 64-multidetector computed tomography (MDCT) [PDF]

, 2010
As multiple new procedures now require better visualization of the aortic valve, we sought to better define the central aortic valve coaptation area seen during diastole on multi-detector row cardiac computed tomography (MDCT).
A Gopal, DS Jassal, GM Feuchtner, GM Feuchtner, H Alkadhi, H Isma’eel, Irfan Zeb, Jigar Kadakia, JJ Chen, Matthew J. Budoff, NE Lebowitz, Sameer Raina, Sameh Elamir, Song Shou Mao, Yasmin S. Hamirani   +14 more
core   +3 more sources

Two-year outcomes after transcatheter or surgical aortic-valve replacement.

New England Journal of Medicine, 2012
BACKGROUND The Placement of Aortic Transcatheter Valves (PARTNER) trial showed that among high-risk patients with aortic stenosis, the 1-year survival rates are similar with transcatheter aortic-valve replacement (TAVR) and surgical replacement. However,
S. Kodali, Mathew R. Williams, Craig R. Smith, L. Svensson, J. Webb, R. Makkar, G. Fontana, T. Dewey, V. Thourani, A. Pichard, M. Fischbein, W. Szeto, Scott Lim, K. Greason, P. Teirstein, S. Malaisrie, P. Douglas, R. Hahn, B. Whisenant, A. Zajarías, Duolao Wang, J. Akin, W. Anderson, M. Leon, T. Investigators   +24 more
semanticscholar   +1 more source

Image-based immersed boundary model of the aortic root [PDF]

arXiv, 2017
Each year, approximately 300,000 heart valve repair or replacement procedures are performed worldwide, including approximately 70,000 aortic valve replacement surgeries in the United States alone. This paper describes progress in constructing anatomically and physiologically realistic immersed boundary (IB) models of the dynamics of the aortic root and
arxiv  

Adverse Cardiovascular Risk Profile and Increased Diurnal Salivary Cortisol in Girls With Turner Syndrome: An Exploratory Study

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Patients with Turner Syndrome (TS) and those exposed to high concentrations of glucocorticoids have a number of characteristics in common, including an increased risk of cardiovascular disease. Pediatric TS patients underwent studies of salivary cortisol (SC) and cortisone (SCn), body composition, continuous glucose monitoring, vascular ...
Lily Jones, Julie Park, Silothabo Dliso, Daniel B. Hawcutt, Alena Shantsila, Gregory Y. H. Lip, Joanne Blair   +6 more
wiley   +1 more source