Results 71 to 80 of about 264,693 (308)

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Follow-Up Report of Patients With Moderate Aortic Valve Regurgitation After Cardiac Surgery [PDF]

Texas Heart Institute Journal
Background: The appropriateness of aortic valve surgery for patients with moderate aortic valve regurgitation undergoing coronary artery bypass graft (CABG), mitral valve replacement (MVR), or both is uncertain.
Arezou Zoroufian, MD, Arya Afrooghe, MD, Manouchehr Ziafat, MD, Arash Jalali, PhD, Mohammadreza Babaei, MD, Pooria Ahmadi, MD, Hakimeh Sadeghian, MD   +6 more
doaj   +1 more source

Transcatheter Aortic Valve Implantation in Dialysis Patients [PDF]

, 2012
Background/Aims: Transcatheter aortic valve implantation (TAVI) has emerged as a new therapeutic option for high-risk patients. However, dialysis patients were excluded from all previous studies.
Baglin A, Braun J, Bryg RJ, Christian Kupatt, Cribier A, Edwards FH, Gerhard Steinbeck, Herzog CA, Iung B, Leon MB, London GM, Lucke JC, Maher ER, Matthias Wessely, Michael Fischereder, Philipp Lange, Rodes-Cabau J, Simon Rau, Smith CR, Stinebaugh J, Straumann E, Tanaka K, Ulf Schönermarck, Urena P, Varadarajan P, Varma R   +25 more
core   +1 more source

A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions

Advanced Science, EarlyView.
This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies, Emanuele Nicotra, Kefan Zhu, Chi Cong Nguyen, Bibhu Sharma, Adrienne Ji, Phuoc Thien Phan, Jingjing Wan, Patrick Pruscino, Hermione Truong, Jelena Rnjak‐Kovacina, Hoang‐Phuong Phan, Christopher Hayward, Nigel Hamilton Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

Surgical Complexity and Outcome of Patients Undergoing Re-do Aortic Valve Surgery

Open Heart, 2020
ObjectivesRe-do aortic valve surgery carries a higher mortality and morbidity compared with first time aortic valve replacement (AVR) and often requires concomitant complex procedures.
Mario Petrou, Renata Greco, Mirko Muretti, Xu Yu Jin, Jasmina Djordjevic, Elaine Hill, Maurizio Renna   +6 more
doaj   +1 more source

Infective endocarditis of quadricuspid aortic valve

Journal of Cardiothoracic Surgery, 2023
Background Infective endocarditis of the aortic valve is a relatively common disease presentation, with surgical intervention a mainstay of treatment in severe cases.
Ariana M. Goodman, Hossein Amirjamshidi, Daniel R. Ziazadeh, Andrew S. Jones, Kazuhiro Hisamoto   +4 more
doaj   +1 more source

Figure-8 Tachycardia Confined to the Anterior Wall of the Left Atrium [PDF]

, 2004
Incisional atrial tachycardias have been described most frequently in patients with previous corrective surgery for congenital heart defects and mitral valve disease.
Liuba, Ioan, Jönsson, Anders, Walfridsson, Håkan   +2 more
core  

Including Aortic Valve Morphology in Computational Fluid Dynamics Simulations: Initial Findings and Application to Aortic Coarctation [PDF]

, 2012
Computational fluid dynamics (CFD) simulations quantifying thoracic aortic flow patterns have not included disturbances from the aortic valve (AoV). 80% of patients with aortic coarctation (CoA) have a bicuspid aortic valve (BAV) which may cause adverse ...
Cava, Joseph Richard, Ellwein, Laura M, Gandy, Kimberly L., Krolikowski, Mary M., LaDisa, John F., Pelech, Andrew N., Samyn, Margaret M., Shadden, Shawn C., Wendell, David C.   +8 more
core   +2 more sources

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Possible predicative role of electrical risk score on transcatheter aortic valve replacement outcomes in older patients. preliminary data [PDF]

, 2018
Background:Transcatheter aortic valve replacement (TAVR) is an effective procedure capable to change the natural history of the degenerative aortic valve stenosis.
DI IORIO, Claudia, Fabietti, Marcella, Magri', Damiano, Mancone, Massimo, Mariani, MARCO VALERIO, Mastropietri, Fabiola, Moscucci, Federica, Parrotta, Ilaria, Piccirillo, Gianfranco, Sardella, Gennaro   +9 more
core   +1 more source