A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
Value of Post-/Pre-Procedural Aortic Regurgitation Ratio vs. Pre-Procedural Aortic Valve Calcium Score to Predict Moderate to Severe Paravalvular Leak Requiring Post-Dilation after Transcatheter Aortic Valve Implantation. [PDF]
J Clin Med, 2023 Uebelacker R +3 more
europepmc +1 more source
The FEBS Journal, EarlyView.NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu +9 more
wiley +1 more source
Aortic Valve Calcium Score as Measured by Native Vs. Contrast Enhanced Computer Tomography and the Implications for the Diagnosis of Severe Aortic Stenosis in TAVR Patients With Low Gradient Aortic Stenosis. [PDF]
, 2021 Mohammad El Garhy, Ellizabeth Costello
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The FEBS Journal, EarlyView.Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi +12 more
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Frontiers in Cardiovascular MedicineBackgroundTranscatheter aortic valve implantation (TAVI) has gained widespread clinical acceptance owing to its minimally invasive approach and enhanced postoperative recovery.
Yan Zhu +13 more
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Journal of Cardiovascular Electrophysiology, EarlyView.ABSTRACT Background Left bundle branch area pacing (LBBAP) has been reported to improve long‐term clinical outcomes in patients requiring permanent pacemaker implantation (PPMI) after transcatheter aortic valve replacement (TAVR). Deep septal pacing (DSP) has emerged as a potential alternative to LBBAP.
Liangzhen Qu, Xueting Duan, Han Chen
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P179 Aortic valve calcium scores in lung cancer screening: a local targeted lung health check program experience [PDF]
, 2023 Anand Iyer +3 more
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Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development
Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah +8 more
wiley +1 more source
Indexing calcium score of the aortic valve to the annulus area improves the grading of aortic stenosis severity in patients within the grey zone of aortic valve calcification [PDF]
, 2022 D Gomes +13 more
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