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Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

open access: yesCardiovascular Research, 2018
Vascular calcification is associated with a significant increase in all-cause mortality and atherosclerotic plaque rupture. Calcification has been determined to be an active process driven in part by vascular smooth muscle cell (VSMC ...
Mei Y Speer   +2 more
exaly   +2 more sources

HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype

open access: yesNature Genetics, 2019
Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending ...
Rajeev Malhotra   +2 more
exaly   +2 more sources

Aortic calcification [PDF]

open access: yesEuropean Journal of Vascular and Endovascular Surgery, 2005
Objectives: Vascular calcification is a complicating factor observed in advanced atherosclerosis. This review summarises the present knowledge regarding abdominal aortic calcification. Design: Literature review.
Mangan, S. H.   +4 more
core   +4 more sources

Relationship between incidentally detected calcification of the mitral valve on 64-row multidetector computed tomography and mitral valve disease on echocardiography

open access: yesInternational Journal of General Medicine, 2012
Mehrnoush Toufan,1 Reza Javadrashid,2 Neda Paak,2 Morteza Gojazadeh,3 Majid Khalili41Cardiovascular Research Center, 2Department of Radiology, 3Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ...
Toufan M   +4 more
doaj   +1 more source

Clinicopathological Features of Anticancer Drug-induced Kidney Injury [PDF]

open access: yesZhongguo quanke yixue, 2022
Background The prevalence of anticancer drug-induced kidney injury is increasing, but related renal pathology studies are still rare. Objective To analyze the clinicopathological characteristics of patients with anticancer drug-related kidney injury ...
GENG Tonghui, LI Han, JIN Jingjing, CHENG Meijuan, ZHANG Shenglei, BAI Yaling, XU Jinsheng
doaj   +1 more source

Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox

open access: yesNature Communications, 2022
Adipocyte differentiation of bone marrow mesenchymal stem/stromal cells (BMSCs) instead of osteoblast formation contributes to age- and menopause-related marrow adiposity and osteoporosis.
Zhenxing Wang   +24 more
semanticscholar   +1 more source

Beneficial effect of the short-chain fatty acid propionate on vascular calcification through intestinal microbiota remodelling

open access: yesMicrobiome, 2022
Background Vascular calcification is a major cause of the high morbidity and mortality of cardiovascular diseases and is closely associated with the intestinal microbiota. Short-chain fatty acids (SCFAs) are derived from the intestinal microbiota and can
Jianlong Yan   +13 more
semanticscholar   +1 more source

Mechanisms and clinical implications of intervertebral disc calcification

open access: yesNature Reviews Rheumatology, 2022
Low back pain is a leading cause of disability worldwide. Intervertebral disc (IVD) degeneration is often associated with low back pain but is sometimes asymptomatic.
U. Zehra   +5 more
semanticscholar   +1 more source

Effect of cardiac function in patients with gastrointestinal cancer with or without acute kidney injury assessed using a non-invasive impedance cardiography: a case-control study

open access: yesBMC Cardiovascular Disorders, 2023
Objectives This study aimed to analyze the possible causes of changes in cardiac function and investigate the feasibility of clinical assessment of gastrointestinal cancer in patients with or without acute kidney injury (AKI) assessed using a non ...
Huihui Chen   +13 more
doaj   +1 more source

Autophagic LC3+ calcified extracellular vesicles initiate cartilage calcification in osteoarthritis

open access: yesScience Advances, 2022
Pathological cartilage calcification plays an important role in osteoarthritis progression but in which the origin of calcified extracellular vesicles (EVs) and their effects remain unknown.
Jianfei Yan   +15 more
semanticscholar   +1 more source

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