Considerations on the Development of Therapeutics in Vascular Calcification [PDF]
Journal of Cardiovascular Development and DiseaseCardiovascular disease is the leading cause of death worldwide. Vascular calcification, the deposition of calcium phosphate mineral in the arterial wall, is the most significant predictor of morbidity and mortality.
Ana M. Valentin Cabrera +2 more
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Calcimimetics and Vascular Calcification. [PDF]
Toxins (Basel)In patients with chronic kidney disease (CKD), cardiovascular events (CVA) are the main cause of morbidity and mortality. Vascular calcification, linked to bone mineral metabolism disorders such as elevated serum phosphate, parathyroid hormone (PTH), and FGF23, well-known uremic toxins, aggravate this risk.
Chandu A +5 more
europepmc +4 more sources
Probiotic Supplementation in Chronic Kidney Disease: Outcomes on Uremic Toxins, Inflammation, and Vascular Calcification from Experimental and Clinical Models [PDF]
ToxinsChronic kidney disease (CKD) is associated with gut microbiota alterations that contribute to increased inflammation and the generation of uremic toxins and may worsen the disease progression.
Teresa Obrero +22 more
doaj +2 more sources
Shifting osteogenesis in vascular calcification [PDF]
JCI Insight, 2021 Transitions between cell fates commonly occur in development and disease. However, reversing an unwanted cell transition in order to treat disease remains an unexplored area.
Jiayi Yao +8 more
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Niacin inhibits vascular calcification via modulating of SIRT1/SIRT6 signaling pathway [PDF]
Cell Death DiscoveryVascular calcification (VC) is a common pathological state that often accompanies calcium-phosphorus metabolism disorder and chronic kidney diseases (CKDs).
Chao-hua Kong +11 more
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NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization [PDF]
Nature CommunicationsVascular calcification, a key risk factor for cardiovascular diseases, is driven by the phenotypic transition of vascular smooth muscle cells from a contractile to an osteogenic phenotype.
Wenjie Guo +14 more
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Clinicopathological Features of Anticancer Drug-induced Kidney Injury [PDF]
Zhongguo quanke yixue, 2022 Background The prevalence of anticancer drug-induced kidney injury is increasing, but related renal pathology studies are still rare. Objective To analyze the clinicopathological characteristics of patients with anticancer drug-related kidney injury ...
GENG Tonghui, LI Han, JIN Jingjing, CHENG Meijuan, ZHANG Shenglei, BAI Yaling, XU Jinsheng
doaj +1 more source
BMC Cardiovascular Disorders, 2023 Objectives This study aimed to analyze the possible causes of changes in cardiac function and investigate the feasibility of clinical assessment of gastrointestinal cancer in patients with or without acute kidney injury (AKI) assessed using a non ...
Huihui Chen +13 more
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Aortic calcification and femoral bone density are independently associated with left ventricular mass in patients with chronic kidney disease [PDF]
, 2012 Background Vascular calcification and reduced bone density are prevalent in chronic kidney disease and linked to increased cardiovascular risk. The mechanism is unknown.
Chue, Colin D. +8 more
core +10 more sources
Correlation between serum level of PARP1 and vascular calcification in hemodialysis patients
Linchuang shenzangbing zazhi, 2023 Objective To explore the correlation between serum level of poly(ADP-ribose) polymerase 1 (PARP1) and vascular calcification in hemodialysis (HD) patients.
Hui Zhang +4 more
doaj +1 more source