Results 1 to 10 of about 69,808 (343)
International Journal of Molecular Sciences, 2023 Runt-related transcription factor 2 (RUNX2) is critical for the modulation of chondrocyte osteoblast differentiation and hypertrophy. Recently discovered RUNX2 somatic mutations, expressional signatures of RUNX2 in normal tissues and tumors, and the ...
Tsung-Chieh Lin
exaly +5 more sources
Clinical and Translational Medicine, 2023 Backgrounds and aims As a central event during liver fibrosis, hepatic stellate cells (HSC) have been thought to be a potential therapeutic target for liver fibrosis.
Li Zhong +9 more
doaj +3 more sources
Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2
International Journal of Molecular Sciences, 2019 Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells, and its expression is upregulated in preosteoblasts, reaches the maximal level in
Toshihisa Komori
exaly +2 more sources
RUNX2 as a promising therapeutic target for malignant tumors
Cancer Management and Research, 2021 Weizhu Zhao,1,2 Haiying Yang,3 Jie Chai,4 Ligang Xing1 1Department of Radiology, Cancer Hospital Affiliated to Shandong First Medical University, Shandong Cancer Hospital and Institute, Jinan, 250117, People’s Republic of China; 2Department of ...
Zhao W, Yang H, Chai J, Xing L
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Regulation of Skeletal Development and Maintenance by Runx2 and Sp7
International Journal of Molecular SciencesRunx2 (runt related transcription factor 2) and Sp7 (Sp7 transcription factor 7) are crucial transcription factors for bone development. The cotranscription factor Cbfb (core binding factor beta), which enhances the DNA-binding capacity of Runx2 and ...
Toshihisa Komori
exaly +2 more sources
Cleidocranial dysplasia: A rare case report
Journal of Pharmacy and Bioallied Sciences, 2023 Cleidocranial dysplasia (CCD) is a rare hereditary disease of unknown etiology which was previously known as cleidocranial dysostosis. It usually follows an autosomal dominant mode of transmission with no predilection of genre or ethnic group.
Akshay A Dhobley +3 more
doaj +1 more source
Contemporary Clinical Dentistry, 2022 Background: It is known that a large number of mediators involved in osteogenesis can influence bone development and repair; however, whether these mediators could be used as markers of bone maturity has yet to be determined.
Daniel Fernando Hergemöller +6 more
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Whole Aspect of Runx2 Functions in Skeletal Development
International Journal of Molecular Sciences, 2022 Runt-related transcription factor 2 (Runx2) is a fundamental transcription factor for bone development. In endochondral ossification, Runx2 induces chondrocyte maturation, enhances chondrocyte proliferation through Indian hedgehog (Ihh) induction, and ...
T. Komori
semanticscholar +1 more source
Frontiers in Bioscience-Landmark, 2023 Background: RUNX2 (Runt-related transcription factor 2) acts as a key regulator in the odontogenic differentiation of human dental pulp stem cells (hDPSCs). Moreover, the inclusion of exon 5 is important for RUNX2 function. Our previous study showed that
Yanan Zhang +4 more
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Glutathione limits RUNX2 oxidation and degradation to regulate bone formation
JCI Insight, 2023 Reactive oxygen species (ROS) are natural products of mitochondrial oxidative metabolism and oxidative protein folding. ROS levels must be well controlled, since elevated ROS has been shown to have deleterious effects on osteoblasts.
G. Hu +6 more
semanticscholar +1 more source