Results 31 to 40 of about 69,808 (343)

Runx2 and Nell-1 in dental follicle progenitor cells regulate bone remodeling and tooth eruption

Stem cell research & therapeutics, 2022
Dental follicles are necessary for tooth eruption, surround the enamel organ and dental papilla, and regulate both the formation and resorption of alveolar bone.
Li Zeng, Hong He, Mingjie Sun, X. Gong, Mengqi Zhou, Yaya Hong, Yong-Jia Wu, Xue-Peng Chen, Qian-Ming Chen   +8 more
semanticscholar   +1 more source

Runt‐related transcription factor‐2 (Runx2) is required for bone matrix protein gene expression in committed osteoblasts in mice

Journal of Bone and Mineral Research, 2021
Runt‐related transcription factor‐2 (Runx2) is an essential transcription factor for osteoblast differentiation. However, its functions after the commitment into osteoblasts are controversial and remain to be clarified.
Xin Qin, Qing Jiang, H. Komori, Chiharu Sakane, Ryo Fukuyama, Yuki Matsuo, K. Ito, T. Miyazaki, T. Komori   +8 more
semanticscholar   +1 more source

Differentiation of mesenchymal stem cells isolated from the amniotic membrane and umbilical cord to osteocytes and the expression of RunX2, Osteonectin, ALP genes

Journal of Current Biomedical Reports, 2022
Mesenchymal stem cells (MSCs) are multipotent cells and able to differentiate into connective tissues such as bone, fat, cartilage, tendon, and muscle. They show to be very potent tools for tissue engineering and regenerative medicine. Several researches
Nooshin Barikrow, Amin Tabasi
doaj   +1 more source

TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes

Nature Communications, 2022
The Ten-eleven translocation (TET) family of dioxygenases mediate cytosine demethylation by catalyzing the oxidation of 5-methylcytosine (5mC). TET-mediated DNA demethylation controls the proper differentiation of embryonic stem cells and TET members ...
Lijun Wang, Xiuling You, Deng-Feng Ruan, Rui Shao, Hai-Qiang Dai, Wei-Liang Shen, Guo-Liang Xu, Wan-Lu Liu, Wei-Guo Zou   +8 more
semanticscholar   +1 more source

Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development

Nature Communications, 2021
The Runt-related transcription factor (Runx) family plays various roles in the homeostasis of cartilage. Here, we examined the role of Runx2 and Runx3 for osteoarthritis development in vivo and in vitro.
Kosei Nagata, H. Hojo, Song-Ho Chang, H. Okada, Fumiko Yano, Ryota Chijimatsu, Y. Omata, D. Mori, Yuma Makii, M. Kawata, Taizo Kaneko, Yasuhide Iwanaga, Hideki Nakamoto, Y. Maenohara, Naohiro Tachibana, Hisatoshi Ishikura, Junya Higuchi, Y. Taniguchi, Shinsuke Ohba, U. Chung, Sakae Tanaka, Taku Saito   +21 more
semanticscholar   +1 more source

Role of RUNX2 in Breast Carcinogenesis [PDF]

International Journal of Molecular Sciences, 2015
RUNX2 is a transcription factor playing the major role in osteogenesis, but it can be involved in DNA damage response, which is crucial for cancer transformation. RUNX2 can interact with cell cycle regulators: cyclin-dependent kinases, pRB and p21Cip1 proteins, as well as the master regulator of the cell cycle, the p53 tumor suppressor.
Wysokinski, Daniel, Blasiak, Janusz, Pawlowska, Elzbieta   +2 more
openaire   +2 more sources

HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes [PDF]

, 2007
HOXA10 is necessary for embryonic patterning of skeletal elements, but its function in bone formation beyond this early developmental stage is unknown. Here we show that HOXA10 contributes to osteogenic lineage determination through activation of Runx2 ...
van Wijnen, AJ, Stein, JL, Lee, SH, Montecino, M, Montecino, Martin A., Lian, JB, Lee, Suk Hee, Stein, Janet L., Hassan, MQ, Van Wijnen, Andre J., Mandeville, Matthew, Mandeville, M, Weiner, B, Weiner, Brian, Lian, Jane B., Stein, GS, Tare, Rahul S., Tare, R., Hassan, Mohammad Q., Stein, Gary S.   +19 more
core   +1 more source

Diminished arachidonate 5-lipoxygenase perturbs phase separation and transcriptional response of Runx2 to reverse pathological ventricular remodeling

EBioMedicine, 2022
Summary Background Arachidonate 5-lipoxygenase (Alox5) belongs to a class of nonheme iron-containing dioxygenases involved in the catalysis of leukotriene biosynthesis.
Saiyang Xie, Mengya Chen, Wen-xi Fang, Shiqiang Liu, Qing-Qing Wu, Chen Liu, Yun Xing, Wen-Ke Shi, Man Xu, Min Zhang, Si Chen, Xiao-Feng Zeng, Sha-Sha Wang, W. Deng, Qi-Zhu Tang   +14 more
semanticscholar   +1 more source

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice [PDF]

, 2010
Nearly every extracellular ligand that has been found to play a role in regulating bone biology acts, at least in part, through MAPK pathways. Nevertheless, much remains to be learned about the contribution of MAPKs to osteoblast biology in vivo. Here we
Zhai, Bo, Weiguo Zou, Shim, Jae-Hyuck, Hu, Dorothy, Lotinun, Sutada, Glimcher, Laurie H., Arthur, Simon; id_orcid, Michael D. Schneider, Yasuyo Sano, Min Xie, Matthew B. Greenblatt, Laurie H. Glimcher, Jae-Hyuck Shim, Roger Davis, Xie, Min, Sano, Yasuyo, Despina Sitara, Schweitzer, Michelle, Park, Jin Mo, Schneider, Michael D., Gygi, Steven, Greenblatt, Matthew B., Baron, Roland, Simon Arthur, Zou, Weiguo, Jin Mo Park, Michelle Schweitzer, Davis, Roger, Roland Baron, Sitara, Despina, Sutada Lotinun, Dorothy Hu, Bo Zhai, Steven Gygi   +33 more
core   +1 more source

Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells

Nature Communications, 2022
In bone marrow, special microenvironments, known as niches, are essential for the maintenance of hematopoietic stem cells (HSCs). A population of mesenchymal stem cells, termed CXC chemokine ligand 12 (CXCL12)-abundant reticular (CAR) cells or leptin ...
Y. Omatsu, Shota Aiba, T. Maeta, K. Higaki, Kazunari Aoki, Hitomi Watanabe, G. Kondoh, R. Nishimura, S. Takeda, U. Chung, T. Nagasawa   +10 more
semanticscholar   +1 more source