Results 31 to 40 of about 41,144 (263)

A Potential Role of RUNX2- RUNT Domain in Modulating the Expression of Genes Involved in Bone Metastases: An In Vitro Study with Melanoma Cells

Cells, 2020
Ectopic expression of RUNX2 has been reported in several tumors. In melanoma cells, the RUNT domain of RUNX2 increases cell proliferation and migration.
Michela Deiana, Luca Dalle Carbonare, Michela Serena, Samuele Cheri, Simona Mutascio, Alberto Gandini, Giulio Innamorati, Pamela Lorenzi, Michela Cumerlato, Jessica Bertacco, Franco Antoniazzi, Maria Grazia Romanelli, Monica Mottes, Donato Zipeto, Maria Teresa Valenti   +14 more
doaj   +1 more source

Immunocytochemistry and western blot test for the in-situ detection of biomarkers of osteogenesis

Scientific Dental Journal, 2022
There are two ways that bones can form: intramembranous and endochondral ossification. Specific osteogenic markers, such as insulin-like growth factor (IGF-1), osteocalcin (OCN), Runt-related transcription factor 2 (RUNX2), and osterix (OSX), accompany ...
Priska Natassya, Endang Winiati Bachtiar
doaj   +1 more source

Comparison Between RunX2 and Osteocalcin Expression Following the Application of Demineralized Freeze-Dried Bone Xenograft (DBFX) and Bovine Hydroxyapatite (BHA) and Their Effect on Bone Defect (In vivo Laboratory Experiment)

Journal of Stem Cell Research and Tissue Engineering, 2022
The use of biomaterial such as bone graft material is highly needed in oral and maxillofacial surgery to overcome bone defect that happened due to various reasons. One of the bone graft that widely used is bovine hydroxyapatite (BHA).
Ikhram Kharis
doaj   +1 more source

RUNX2 (6p21.1) amplification in osteosarcoma

Human Pathology, 2019
Prior cytogenetic profiling of osteosarcomas has suggested that amplifications at the 6p12-21 locus are relatively common alterations in these tumors. However, these studies have been limited by variable testing methodologies used as well as by the relatively small numbers of cases that have been analyzed.
Sounak, Gupta, Tatsuo, Ito, Deepu, Alex, Chad M, Vanderbilt, Jason C, Chang, Nasrin, Islamdoust, Yanming, Zhang, Khedoudja, Nafa, John, Healey, Marc, Ladanyi, Meera R, Hameed   +10 more
openaire   +3 more sources

MICROmanagement of Runx2 Function in Skeletal Cells [PDF]

Current Molecular Biology Reports, 2019
Precise and temporal expression of Runx2 and its regulatory transcriptional network is a key determinant for the intricate cellular and developmental processes in adult bone tissue formation. This review analyzes how microRNA functions to regulate this network, and how dysregulation results in bone disorders.Similar to other biologic processes ...
Benjamin J, Wildman, Tanner C, Godfrey, Mohammad, Rehan, Yuechuan, Chen, Lubana H, Afreen, Quamarul, Hassan   +5 more
openaire   +2 more sources

RUNX2 mutations in cleidocranial dysplasia

Genetics and Molecular Research, 2013
The runt-related transcription factor 2 gene (RUNX2), which is also known as CBFA1, is a master regulatory gene in bone formation. Mutations in RUNX2 have been identified in cleidocranial dysplasia (CCD) patients. CCD is a rare autosomal dominant skeletal dysplasia that is characterized by delayed closure of cranial sutures, aplastic or hypoplastic ...
K-E, Lee, F, Seymen, J, Ko, M, Yildirim, E B, Tuna, K, Gencay, J-W, Kim   +6 more
openaire   +2 more sources

KLF2 reduces dexamethasone-induced injury to growth plate chondrocytes by inhibiting the Runx2-mediated PI3K/AKT and ERK signalling pathways

Autoimmunity, 2023
Dexamethasone (Dex) is a type of glucocorticoid drug. Long term use can induce growth plate chondrocytes (GPCs) apoptosis, impair differentiation, and inhibit cell proliferation and bone growth.
Yulong Ma, Tao Peng, Xudong Yao, Chaonan Sun, Xiaowei Wang   +4 more
doaj   +1 more source

Carbon Monoxide Releasing Molecule-3 Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Carbon Monoxide Release

Drug Design, Development and Therapy, 2021
Hui Chen,1,2 Yan Dai,1,3 Jing Cui,4 Xiaochun Yin,2 Wei Feng,2 Meiyi lv,1,5 Hui Song1 1Department of VIP Center, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration
Chen H, Dai Y, Cui J, Yin X, Feng W, lv M, Song H   +6 more
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RUNX2 Reverses p53-Induced Chemotherapy Resistance in Gastric Cancer

Pharmacogenomics and Personalized Medicine, 2023
Yuan Huang,1 Lu Liang,2 Yong-Xiang Zhao,3 Bi-Hui Yao,2 Rui-Min Zhang,3 Lei Song,2 Zhong-Tao Zhang1 1Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People’s Republic of China; 2Department of ...
Huang Y, Liang L, Zhao YX, Yao BH, Zhang RM, Song L, Zhang ZT   +6 more
doaj  

Influence of photobiomodulation and vitamin D on osteoblastic differentiation of human periodontal ligament stem cells and bone-like tissue formation through enzymatic activity and gene expression

Biomolecular Concepts, 2020
Human periodontal ligament stem cells (HPDLSCs) are a unique population of mesenchymal stem cells (MSCs). Recently, the positive effects of photobiomodulation on the regulation of MSCs proliferation and osteogenic differentiation have gained significant ...
Abdelgawad Latifa Mohamed, Abdelaziz Asmaa Mohamed, Sabry Dina, Abdelgwad Marwa   +3 more
doaj   +1 more source