Results 31 to 40 of about 66,303 (295)

Runx2 Integrates Estrogen Activity in Osteoblasts [PDF]

Journal of Biological Chemistry, 2003
Steroids significantly effect skeletal integrity. For example, bone mass decreases with glucocorticoid excess or with estrogen depletion after menopause. Glucocorticoid suppresses gene expression by an essential skeletal tissue transcription factor, Runx2, in rat osteoblasts.
Thomas L, McCarthy, Wei-Zhong, Chang, Yuan, Liu, Michael, Centrella   +3 more
openaire   +2 more sources

Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling [PDF]

, 2011
Vascular calcification (VC) is the process of deposition of calcium phosphate crystals in the blood vessel wall, with a central role for vascular smooth muscle cells (VSMCs). VC is highly prevalent in chronic kidney disease (CKD) patients and thought, in
A Tagariello, AK Cheung, AN Kapustin, AP Sage, BA Willems, C Hough, C Surmann-Schmitt, C-H Heldin, CA Gregory, CM Giachelli, CM Shanahan, CM Shanahan, CM Shanahan, CR Dhore, CS Viegas, CS Viegas, CS Viegas, D Proudfoot, E Neven, F Guerrero, F Liu, JL Hunt, KM McCabe, LJ Schurgers, LJ Schurgers, LS Shankman, M Jeune Le, M Mizobuchi, MG Frid, MJ Duer, ML Chatrou, MR Alexander, MS Rafael, MY Speer, N Eitzinger, QQ Huang, R Shroff, RJ Rennenberg, S Feil, S Jono, S Olechnowicz-Tietz, SA Steitz, T Cai, T Lin, VA Jesus Perez de, VP Iyemere, X Li, Y Liu, YJ Lee   +48 more
core   +2 more sources

RUNX2 (6p21.1) amplification in osteosarcoma

Human Pathology, 2019
Prior cytogenetic profiling of osteosarcomas has suggested that amplifications at the 6p12-21 locus are relatively common alterations in these tumors. However, these studies have been limited by variable testing methodologies used as well as by the relatively small numbers of cases that have been analyzed.
Sounak, Gupta, Tatsuo, Ito, Deepu, Alex, Chad M, Vanderbilt, Jason C, Chang, Nasrin, Islamdoust, Yanming, Zhang, Khedoudja, Nafa, John, Healey, Marc, Ladanyi, Meera R, Hameed   +10 more
openaire   +3 more sources

Inducible regulation of Runx2-stimulated osteogenesis [PDF]

Gene Therapy, 2006
Ex vivo gene therapy is a promising approach to orthopedic regenerative medicine. These strategies typically focus on the constitutive overexpression of osteogenic factors to induce osteoblastic differentiation and matrix mineralization. However, the unregulated production of osteoinductive molecules has also resulted in abnormal bone formation and ...
C A, Gersbach, J M, Le Doux, R E, Guldberg, A J, García   +3 more
openaire   +2 more sources

Comparison Between RunX2 and Osteocalcin Expression Following the Application of Demineralized Freeze-Dried Bone Xenograft (DBFX) and Bovine Hydroxyapatite (BHA) and Their Effect on Bone Defect (In vivo Laboratory Experiment)

Journal of Stem Cell Research and Tissue Engineering, 2022
The use of biomaterial such as bone graft material is highly needed in oral and maxillofacial surgery to overcome bone defect that happened due to various reasons. One of the bone graft that widely used is bovine hydroxyapatite (BHA).
Ikhram Kharis
doaj   +1 more source

Runx2: of bone and stretch

The International Journal of Biochemistry & Cell Biology, 2008
Runx2 is a key transcriptional modulator of osteoblast differentiation that plays a fundamental role in osteoblast maturation and homeostasis. Runx2-null mice despite normal skeletal patterning have no osteoblasts and consequently bone tissue. Mutations of the runx2 gene in humans cause cleidocranial dysplasia.
Ziros, P.G., Basdra, E.K., Papavassiliou, A.G.   +2 more
openaire   +3 more sources

RUNX2 mutations in cleidocranial dysplasia

Genetics and Molecular Research, 2013
The runt-related transcription factor 2 gene (RUNX2), which is also known as CBFA1, is a master regulatory gene in bone formation. Mutations in RUNX2 have been identified in cleidocranial dysplasia (CCD) patients. CCD is a rare autosomal dominant skeletal dysplasia that is characterized by delayed closure of cranial sutures, aplastic or hypoplastic ...
K-E, Lee, F, Seymen, J, Ko, M, Yildirim, E B, Tuna, K, Gencay, J-W, Kim   +6 more
openaire   +2 more sources

Impaired osteoblast differentiation in annexin A2- and -A5-deficient cells. [PDF]

, 2014
Annexins are a class of calcium-binding proteins with diverse functions in the regulation of lipid rafts, inflammation, fibrinolysis, transcriptional programming and ion transport.
Genetos, Damian C, Karin, Norman J, Weber, Thomas J, Wong, Alice, Yellowley, Clare E   +4 more
core   +7 more sources

A perfusion culture system for assessing bone marrow stromal cell differentiation on PLGA scaffolds for bone repair [PDF]

, 2018
Biomaterials development for bone repair is currently hindered by the lack of physiologically relevant in vitro testing systems. Here we describe the novel use of a bi-directional perfusion bioreactor to support the long term culture of human bone marrow
Alini, Mauro, Bara, Jennifer J, Bardsley, Katie, El Haj, Alicia J, Moser, Caroline, Stoddart, Martin J   +5 more
core   +2 more sources

Spatial Distribution of Macrophages During Callus Formation and Maturation Reveals Close Crosstalk Between Macrophages and Newly Forming Vessels [PDF]

, 2019
Macrophages are essential players in the process of fracture healing, acting by remodeling of the extracellular matrix and enabling vascularization. Whilst activated macrophages of M1-like phenotype are present in the initial pro-inflammatory phase of ...
Aulich, Linus, Buttgereit, Frank, Duda, Georg N., Fiedler, Alexander F., Gaber, Timo, Hauser, Anja E., Köhler, Markus, Lang, Annemarie, Niesner, Raluca A., Rauch, Ariana, Schmidt-Bleek, Katharina, Stefanowski, Jonathan   +11 more
core   +1 more source