Results 31 to 40 of about 52,415 (197)

RUNX2 (6p21.1) amplification in osteosarcoma

Human Pathology, 2019
Prior cytogenetic profiling of osteosarcomas has suggested that amplifications at the 6p12-21 locus are relatively common alterations in these tumors. However, these studies have been limited by variable testing methodologies used as well as by the relatively small numbers of cases that have been analyzed.
Sounak, Gupta, Tatsuo, Ito, Deepu, Alex, Chad M, Vanderbilt, Jason C, Chang, Nasrin, Islamdoust, Yanming, Zhang, Khedoudja, Nafa, John, Healey, Marc, Ladanyi, Meera R, Hameed   +10 more
openaire   +3 more sources

MICROmanagement of Runx2 Function in Skeletal Cells [PDF]

Current Molecular Biology Reports, 2019
Precise and temporal expression of Runx2 and its regulatory transcriptional network is a key determinant for the intricate cellular and developmental processes in adult bone tissue formation. This review analyzes how microRNA functions to regulate this network, and how dysregulation results in bone disorders.Similar to other biologic processes ...
Benjamin J, Wildman, Tanner C, Godfrey, Mohammad, Rehan, Yuechuan, Chen, Lubana H, Afreen, Quamarul, Hassan   +5 more
openaire   +2 more sources

RUNX2 overexpression generates endocrine resistance in human luminal breast cancer xenografts

, 2021
T47D and IBH6 cells that overexpress RUNX2 show high levels of FGFR2 and FGF2, supporting the hypothesis that FGF2 increases RUNX2 and, in turn, RUNX2 increases FGF2, maintaining a positive loop.
Luthy, Isabel Alicia, Riggio, Marina, Vanzulli, Silvia, Pérez Piñero, Cecilia, Lamb, Caroline Ana, Rodríguez, Maria Sol, Lanari, Claudia Lee Malvina   +6 more
core   +1 more source

RUNX2 mutations in cleidocranial dysplasia

Genetics and Molecular Research, 2013
The runt-related transcription factor 2 gene (RUNX2), which is also known as CBFA1, is a master regulatory gene in bone formation. Mutations in RUNX2 have been identified in cleidocranial dysplasia (CCD) patients. CCD is a rare autosomal dominant skeletal dysplasia that is characterized by delayed closure of cranial sutures, aplastic or hypoplastic ...
K-E, Lee, F, Seymen, J, Ko, M, Yildirim, E B, Tuna, K, Gencay, J-W, Kim   +6 more
openaire   +2 more sources

Carbon Monoxide Releasing Molecule-3 Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Carbon Monoxide Release

Drug Design, Development and Therapy, 2021
Hui Chen,1,2 Yan Dai,1,3 Jing Cui,4 Xiaochun Yin,2 Wei Feng,2 Meiyi lv,1,5 Hui Song1 1Department of VIP Center, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration
Chen H, Dai Y, Cui J, Yin X, Feng W, lv M, Song H   +6 more
doaj  

Cleidocranial dysplasia – A case report discussing the clinical and radiological manifestations

Journal of Marine Medical Society, 2020
Cleidocranial dysplasia (CCD) is a generalized skeletal disorder characterized by typical clinical and radiological abnormalities which include open cranial sutures and fontanelle, presence of Wormian bones, characteristic abnormalities of the clavicle ...
Vikram Singh Shekhawat, Yoginder Singh Gulati   +1 more
doaj   +1 more source

Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-beta and Runx2 in bone is required for hearing [PDF]

, 2010
Publisher version: http://www.nature.com/embor/journal/v11/n10/full/embor2010135.htmlDA - 20100917 IS - 1469-3178 (Electronic) IS - 1469-221X (Linking) LA - ENG PT - JOURNAL ARTICLEDA - 20100917 IS - 1469-3178 (Electronic) IS - 1469-221X (Linking) LA ...
Anil Lalwani, Chin, EN, Carol G Chen, Derynck, R, Marshall, GW, Butcher, K, Guive Balooch, Lawrence Lustig, Akil, O, Porter, AE, Robert O Ritchie, Grayson W Marshall, Jacob Johnson, Lalwani, A, Sally J Marshall, Omar Akil, Emily N Chin, Balooch, G, Humphrey, MB, Lustig, L, Delia S Brauer, Rik Derynck, Kristin Butcher, Marshall, SJ, Richard A Schneider, Tamara Alliston, Alliston, T, Chen, CG, Johnson, J, Jolie L Chang, Brauer, DS, Alexandra E Porter, Schneider, RA, Chang, JL, Ritchie, RO, Mary Beth Humphrey   +35 more
core   +1 more source

East Java green tea methanolic extract can enhance RUNX2 and Osterix expression during orthodontic tooth movement in vivo [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2020
Context: Alveolar bone remodeling is important to achieve an optimal Orthodontic Tooth Movement (OTM). Runt-related transcription factor 2 (RUNX2) and Osterix (OSX) expression are important for bone remodeling.
Putri I. Sitasari, Ida B. Narmada, Thalca Hamid, Ari Triwardhani, lexander Patera Nugraha, Dwi Rahmawati   +5 more
doaj  

A Potential Role of RUNX2- RUNT Domain in Modulating the Expression of Genes Involved in Bone Metastases: An In Vitro Study with Melanoma Cells

Cells, 2020
Ectopic expression of RUNX2 has been reported in several tumors. In melanoma cells, the RUNT domain of RUNX2 increases cell proliferation and migration.
Michela Deiana, Luca Dalle Carbonare, Michela Serena, Samuele Cheri, Simona Mutascio, Alberto Gandini, Giulio Innamorati, Pamela Lorenzi, Michela Cumerlato, Jessica Bertacco, Franco Antoniazzi, Maria Grazia Romanelli, Monica Mottes, Donato Zipeto, Maria Teresa Valenti   +14 more
doaj   +1 more source

Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids. [PDF]

PLoS ONE, 2014
The Runt-related transcription factor 2 (Runx2) gene encodes the transcription factor Runx2, which is the master regulator of osteoblast development; insufficiency of this protein causes disorders of bone development such as cleidocranial dysplasia ...
Hideaki Okura, Shintaro Sato, Sari Kishikawa, Satoshi Kaneto, Tomoki Nakashima, Nobuaki Yoshida, Hiroshi Takayanagi, Hiroshi Kiyono   +7 more
doaj   +1 more source