Results 11 to 20 of about 41,144 (263)

Branch site mutated mice revealed distinct roles of two Runx2 isoforms in bone development [PDF]

Frontiers in Cell and Developmental Biology
Runx2 is a key regulator of osteoblast differentiation and chondrocyte maturation. However, the distinct functions of the two functional isoforms remain to be clarified.
Qing Jiang, Manyu Zhang, Haoyunyan Jin, Ziheng Zhang, Chiharu Sakane, Yuki Matsuo, Yuki Matsuo, Simeng Lai, Wen Zhang, Huilin Yang, Huilin Yang, Toshihisa Komori, Xin Qin   +12 more
doaj   +2 more sources

Runx2 acetylation enhances pulmonary inflammation in chronic obstructive pulmonary disease through activating CDK8 [PDF]

Respiratory Research
Background Runt-related transcription factor 2 (Runx2), a transcription factor of the RUNX family, is involved in various inflammatory diseases. However, the role of Runx2 was unclear in chronic obstructive pulmonary disease (COPD).
Yi-Cheng Ma, Dan-Lei Chen, Ju-Hong Wu, Fei Tang, Tian-Rui Sui, Zhi-Yong Wu, Qi-Yuan He, Yu Wang, Min-Min Tang, Dong-Xu Hua, Jing Yang, Hui Zhao, Jun Fei, Wei Cao, Lin Fu   +14 more
doaj   +2 more sources

Cleidocranial dysplasia: A rare case report

Journal of Pharmacy and Bioallied Sciences, 2023
Cleidocranial dysplasia (CCD) is a rare hereditary disease of unknown etiology which was previously known as cleidocranial dysostosis. It usually follows an autosomal dominant mode of transmission with no predilection of genre or ethnic group.
Akshay A Dhobley, Aparna V Thombre, Dipak Ghatage, Ranu Ingole Patil   +3 more
doaj   +1 more source

Osteocalcin and Runx2 expression in anterior maxillary reconstructions using bone xenografts associated to bone marrow aspirate concentrate

Contemporary Clinical Dentistry, 2022
Background: It is known that a large number of mediators involved in osteogenesis can influence bone development and repair; however, whether these mediators could be used as markers of bone maturity has yet to be determined.
Daniel Fernando Hergemöller, André Antonio Pelegrine, Paulo José Pasquali, Luis Guilherme Scavone de Macedo, Marcelo Lucchesi Teixeira, Peter Karyen Moy, Antonio Carlos Aloise   +6 more
doaj   +1 more source

HnRNP A1 Suppresses the Odontogenic Differentiation and the Inclusion of RUNX2 Exon 5 of Dental Mesenchymal Cells

Frontiers in Bioscience-Landmark, 2023
Background: RUNX2 (Runt-related transcription factor 2) acts as a key regulator in the odontogenic differentiation of human dental pulp stem cells (hDPSCs). Moreover, the inclusion of exon 5 is important for RUNX2 function. Our previous study showed that
Yanan Zhang, Junjun Huang, Lingyan Yan, Rong Jia, Jihua Guo   +4 more
doaj   +1 more source

The Role of RUNX2 in Osteosarcoma Oncogenesis [PDF]

Sarcoma, 2011
Osteosarcoma is an aggressive but ill-understood cancer of bone that predominantly affects adolescents. Its rarity and biological heterogeneity have limited studies of its molecular basis. In recent years, an important role has emerged for the RUNX2 “platform protein” in osteosarcoma oncogenesis. RUNX proteins are DNA-binding transcription factors that
Martin, J. W., Zielenska, M., Stein, G. S., van Wijnen, A. J., Squire, J. A.   +4 more
openaire   +3 more sources

Phenotype from SAMD9 Mutation at 7p21.2 Appears Attenuated by Novel Compound Heterozygous Variants at RUNX2 and SALL1

Global Medical Genetics, 2022
Sterile α motif domain-containing protein 9 (SAMD9) is a regulatory protein centrally involved in cell proliferation and apoptosis. Mapped to 7p21.2, variants in SAMD9 have been reported in
E. Scott Sills, Samuel H. Wood
doaj   +1 more source

The effect of different intensities Resistance Training on expression mir-204 and transcription factors of osteogenic, Runx2 and biomechanical properties on bone in Old male Wistar rats [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2021
Purpose:  Bones are largely influenced by nutrition, activity levels and lifestyle, and structural adaptations in the form and size of the bone occur by the forces of weight bearing and forces applied by the muscles.
ZAHRA HEMATI FARSANI, Ebrahim Banitalebi, Mohamad Faramarzi, Amin Bigham-Sadegh   +3 more
doaj   +1 more source

Phoenix dactilyfera L. Pits Extract Restored Bone Homeostasis in Glucocorticoid-Induced Osteoporotic Animal Model through the Antioxidant Effect and Wnt5a Non-Canonical Signaling

Antioxidants, 2022
Oxidative stress associated with long-term glucocorticoids administration is a route through which secondary osteoporosis can be developed. The therapeutic potential of Phoenix dactilyfera L.
Samar R. Saleh, Doaa A. Ghareeb, Aliaa A. Masoud, Eman Sheta, Mohamed Nabil, Inas M. Masoud, Adham M. Maher   +6 more
doaj   +1 more source

Effect of cocoa administration during orthodontic tooth movement on RUNX2, calcium levels, and osteoclast bone-resorbing activity in rats [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2022
Context: Cocoa contains caffeine-rich methylxanthine, which promotes accelerated orthodontic tooth movement. Caffeine affects calcium ion equilibrium, causing low bone density and shortening orthodontic treatment.
Ananto Ali Alhasyimi, Pinandi Sri Pudyani   +1 more
doaj   +1 more source