Results 11 to 20 of about 52,415 (197)
The International Journal of Biochemistry & Cell Biology, 2008 Runx2 is a key transcriptional modulator of osteoblast differentiation that plays a fundamental role in osteoblast maturation and homeostasis. Runx2-null mice despite normal skeletal patterning have no osteoblasts and consequently bone tissue.
Basdra, E.K. +2 more
core +5 more sources
The Role of RUNX2 in Osteosarcoma Oncogenesis [PDF]
Sarcoma, 2011 Osteosarcoma is an aggressive but ill-understood cancer of bone that predominantly affects adolescents. Its rarity and biological heterogeneity have limited studies of its molecular basis.
J. A. Squire +4 more
core +4 more sources
Role of RUNX2 in Breast Carcinogenesis [PDF]
International Journal of Molecular Sciences, 2015 RUNX2 is a transcription factor playing the major role in osteogenesis, but it can be involved in DNA damage response, which is crucial for cancer transformation.
Elzbieta Pawlowska +2 more
core +3 more sources
A Runx2 threshold for the cleidocranial dysplasia phenotype [PDF]
Human Molecular Genetics, 2010 Cleidocranial dysplasia (CCD) in humans is an autosomal-dominant skeletal disease that results from mutations in the bone-specific transcription factor RUNX2 (CBFA1/AML3). However, distinct RUNX2 mutations in CCD do not correlate with the severity of the
Pratap, Jitesh +12 more
core +4 more sources
Investigating the role of Runx2 in haematopoiesis
Self-renewing multipotent haematopoietic stem cells (HSCs) are a rare but vital cell population supporting life-long homeostasis of the entire blood and immune system.
Meaker, Grace Ann
core +2 more sources
TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts.
PLoS ONE, 2011 Deletion of TIEG1/KLF10 in mice results in a gender specific osteopenic skeletal phenotype with significant defects in both cortical and trabecular bone, which are observed only in female animals.
John R Hawse +10 more
doaj +2 more sources
Runt-related transcription factor 2 (Runx2) measurement in phytoestrogen-induced bone: a comparison of western blot and immunohistochemistry methods [PDF]
, 2022 Estrogen deficiency can contribute to osteoporosis in postmenopausal women. Phytoestrogens are becoming more widely recognized as potential estrogen replacement therapy. The administration of phytoestrogens can cause bone formation, which is marked by an
Ma'arif, Burhan +5 more
core +4 more sources
The roles of osteoclasts and RUNX2 in the progression of prostate cancer bone metastases [PDF]
, 2021 Metastasis to the skeleton is the major cause of death from prostate cancer (PC). Patients with metastatic PC are treated with androgen deprivation therapy (ADT) to decrease testosterone levels and thereby inhibit further growth of the tumor.
Huang, Junchi
core +1 more source
Journal of Stem Cell Research and Tissue Engineering, 2022 The use of biomaterial such as bone graft material is highly needed in oral and maxillofacial surgery to overcome bone defect that happened due to various reasons. One of the bone graft that widely used is bovine hydroxyapatite (BHA).
Ikhram Kharis
doaj +1 more source
HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes [PDF]
, 2007 HOXA10 is necessary for embryonic patterning of skeletal elements, but its function in bone formation beyond this early developmental stage is unknown. Here we show that HOXA10 contributes to osteogenic lineage determination through activation of Runx2 ...
van Wijnen, AJ +19 more
core +1 more source