Results 11 to 20 of about 69,808 (343)
Effect of cocoa administration during orthodontic tooth movement on RUNX2, calcium levels, and osteoclast bone-resorbing activity in rats [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2022 Context: Cocoa contains caffeine-rich methylxanthine, which promotes accelerated orthodontic tooth movement. Caffeine affects calcium ion equilibrium, causing low bone density and shortening orthodontic treatment.
Ananto Ali Alhasyimi +1 more
doaj +2 more sources
The International Journal of Biochemistry & Cell Biology, 2008 Runx2 is a key transcriptional modulator of osteoblast differentiation that plays a fundamental role in osteoblast maturation and homeostasis. Runx2-null mice despite normal skeletal patterning have no osteoblasts and consequently bone tissue. Mutations of the runx2 gene in humans cause cleidocranial dysplasia.
Ziros, P.G. +2 more
openaire +4 more sources
Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids. [PDF]
PLoS ONE, 2014 The Runt-related transcription factor 2 (Runx2) gene encodes the transcription factor Runx2, which is the master regulator of osteoblast development; insufficiency of this protein causes disorders of bone development such as cleidocranial dysplasia ...
Hideaki Okura +7 more
doaj +2 more sources
A Runx2 threshold for the cleidocranial dysplasia phenotype [PDF]
Human Molecular Genetics, 2008 Cleidocranial dysplasia (CCD) in humans is an autosomal-dominant skeletal disease that results from mutations in the bone-specific transcription factor RUNX2 (CBFA1/AML3). However, distinct RUNX2 mutations in CCD do not correlate with the severity of the disease.
Lou, Yang +12 more
openaire +4 more sources
Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts
PLOS Genetics, 2020 Chondrocytes proliferate and mature into hypertrophic chondrocytes. Vascular invasion into the cartilage occurs in the terminal hypertrophic chondrocyte layer, and terminal hypertrophic chondrocytes die by apoptosis or transdifferentiate into osteoblasts.
Xin Qin +10 more
semanticscholar +5 more sources
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation [PDF]
Nature Communications, 2020 The osteoblast differentiation capacity of skeletal stem cells (SSCs) must be tightly regulated, as inadequate bone formation results in low bone mass and skeletal fragility, and over-exuberant osteogenesis results in heterotopic ossification (HO) of ...
Jung-Min Kim +18 more
semanticscholar +2 more sources
Functional cooperation between vitamin D receptor and Runx2 in vitamin D-induced vascular calcification. [PDF]
PLoS ONE, 2013 The transdifferentiation of vascular smooth muscle cells (VSMCs) into osteoblast-like cells has been implicated in the context of vascular calcification. We investigated the roles of vitamin D receptor (Vdr) and runt-related transcription factor 2 (Runx2)
Min-Su Han +11 more
doaj +2 more sources
Immunity, 2023 The integrin CD49a marks highly cytotoxic epidermal-tissue-resident memory (TRM) cells, but their differentiation from circulating populations remains poorly defined.
B. Zitti +18 more
semanticscholar +1 more source
Global Medical Genetics, 2022 Sterile α motif domain-containing protein 9 (SAMD9) is a regulatory protein centrally involved in cell proliferation and apoptosis. Mapped to 7p21.2, variants in SAMD9 have been reported in
E. Scott Sills, Samuel H. Wood
doaj +1 more source
Antioxidants, 2022 Oxidative stress associated with long-term glucocorticoids administration is a route through which secondary osteoporosis can be developed. The therapeutic potential of Phoenix dactilyfera L.
Samar R. Saleh +6 more
doaj +1 more source