Results 11 to 20 of about 66,303 (295)
Molecules, 2020 RUNX2, a master osteogenic transcript ion factor, is overexpressed in several cancer cells; in melanoma it promotes cells migration and invasion as well as neoangiogenesis.
Maria Teresa Valenti +5 more
doaj +1 more source
Runx2 rs59983488 polymorphism in class II malocclusion in the Indonesian subpopulation
Dental Journal, 2021 Background: Class II malocclusion is one of the main orthodontic issues for patients in seeking treatment. The prevalence of class II malocclusion varies in different populations.
Fadli Jazaldi +4 more
doaj +1 more source
Impact of antibiotics on the proliferation and differentiation of human adipose-derived mesenchymal stem cells [PDF]
, 2017 Adipose tissue is a promising source of mesenchymal stem cells. Their potential to differentiate and regenerate other types of tissues may be affected by several factors. This may be due to in vitro cell-culture conditions, especially the supplementation
Gola, Joanna +6 more
core +10 more sources
Shh–Gli2–Runx2 inhibits vascular calcification
Nephrology Dialysis Transplantation, 2023 ABSTRACT Background In patients with chronic kidney disease (CKD), vascular calcification (VC) is common and is associated with a higher risk of all-cause mortality. Shh, one ligand for Hedgehog (Hh) signaling, participates in osteogenesis and several cardiovascular diseases.
Aoran Huang +6 more
openaire +2 more sources
LncRNA MYCNOS promotes prostate cancer cell proliferation by regulating the miR-466/RUNX2 axis
Journal of Biological Research - Thessaloniki, 2022 The function of lncRNA MYCNOS has only been reported in hepatocellular carcinoma. We studied the role of MYCNOS in prostate cancer (PC). In this study, MYCNOS expression in tissue samples from 64 PC patients was studied by RT-qPCR. Base pairing formed by
Guiliu Chen +3 more
doaj +1 more source
International Journal of Molecular Sciences, 2023 Runt-related transcription factor 2 (RUNX2) is critical for the modulation of chondrocyte osteoblast differentiation and hypertrophy. Recently discovered RUNX2 somatic mutations, expressional signatures of RUNX2 in normal tissues and tumors, and the prognostic and clinical significance of RUNX2 in many types of cancer have attracted attention and led ...
openaire +2 more sources
Journal of Current Biomedical Reports, 2022 Mesenchymal stem cells (MSCs) are multipotent cells and able to differentiate into connective tissues such as bone, fat, cartilage, tendon, and muscle. They show to be very potent tools for tissue engineering and regenerative medicine. Several researches
Nooshin Barikrow, Amin Tabasi
doaj +1 more source
Role of RUNX2 in Breast Carcinogenesis [PDF]
International Journal of Molecular Sciences, 2015 RUNX2 is a transcription factor playing the major role in osteogenesis, but it can be involved in DNA damage response, which is crucial for cancer transformation. RUNX2 can interact with cell cycle regulators: cyclin-dependent kinases, pRB and p21Cip1 proteins, as well as the master regulator of the cell cycle, the p53 tumor suppressor.
Wysokinski, Daniel +2 more
openaire +2 more sources
Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1. [PDF]
, 2015 In tumor cells, two factors are abnormally increased that contribute to metastatic bone disease: Runx2, a transcription factor that promotes expression of metastasis related and osteolytic genes; and IL-11, a secreted osteolytic cytokine.
Afzal +59 more
core +2 more sources
New Insights into the Runt Domain of RUNX2 in Melanoma Cell Proliferation and Migration [PDF]
, 2018 The mortality rate for malignant melanoma (MM) is very high, since it is highly invasive and resistant to chemotherapeutic treatments. The modulation of some transcription factors affects cellular processes in MM.
Antoniazzi, Franco +19 more
core +2 more sources