Results 41 to 50 of about 66,303 (295)
Autoimmunity, 2023 Dexamethasone (Dex) is a type of glucocorticoid drug. Long term use can induce growth plate chondrocytes (GPCs) apoptosis, impair differentiation, and inhibit cell proliferation and bone growth.
Yulong Ma +4 more
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Surface guidance of stem cell behavior: Chemically tailored co-presentation of integrin-binding peptides stimulates osteogenic differentiation in vitro and bone formation in vivo [PDF]
, 2016 Surface modification stands out as a versatile technique to create instructive biomaterials that are able to actively direct stem cell fate. Chemical functionalization of titanium has been used in this work to stimulate the differentiation of human ...
Dashnyam, Khandmaa +8 more
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Runx1 and Runx2 cooperate during sternal morphogenesis [PDF]
Development, 2010 Chondrocyte differentiation is strictly regulated by various transcription factors, including Runx2 and Runx3; however, the physiological role of Runx1 in chondrocyte differentiation remains unknown. To examine the role of Runx1, we generated mesenchymal-cell-specific and chondrocyte-specific Runx1-deficient mice [Prx1 Runx1f/f mice and α1(II) Runx1f/f
Ayako, Kimura +18 more
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Drug Design, Development and Therapy, 2021 Hui Chen,1,2 Yan Dai,1,3 Jing Cui,4 Xiaochun Yin,2 Wei Feng,2 Meiyi lv,1,5 Hui Song1 1Department of VIP Center, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration
Chen H +6 more
doaj
HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype. [PDF]
, 2019 Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending ...
Bagchi, Aranya +49 more
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Bone Morphogenetic Protein-2 Stimulates Runx2 Acetylation [PDF]
Journal of Biological Chemistry, 2006 Runx2/Cbfa1/Pebp2aA is a global regulator of osteogenesis and is crucial for regulating the expression of bone-specific genes. Runx2 is a major target of the bone morphogenetic protein (BMP) pathway. Genetic analysis has revealed that Runx2 is degraded through a Smurf-mediated ubiquitination pathway, and its activity is inhibited by HDAC4.
Eun-Joo, Jeon +13 more
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RUNX2 Reverses p53-Induced Chemotherapy Resistance in Gastric Cancer
Pharmacogenomics and Personalized Medicine, 2023 Yuan Huang,1 Lu Liang,2 Yong-Xiang Zhao,3 Bi-Hui Yao,2 Rui-Min Zhang,3 Lei Song,2 Zhong-Tao Zhang1 1Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People’s Republic of China; 2Department of ...
Huang Y +6 more
doaj
The galectin-3/RAGE dyad modulates vascular osteogenesis in atherosclerosis [PDF]
, 2013 Vascular calcification correlates with inflammation and plaque instability in a dual manner, depending on the spotty/granular (micro) or sheet-like/lamellated (macro) pattern of calcification.
BLASETTI FANTAUZZI, Claudia +9 more
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MICROmanagement of Runx2 Function in Skeletal Cells [PDF]
Current Molecular Biology Reports, 2019 Precise and temporal expression of Runx2 and its regulatory transcriptional network is a key determinant for the intricate cellular and developmental processes in adult bone tissue formation. This review analyzes how microRNA functions to regulate this network, and how dysregulation results in bone disorders.Similar to other biologic processes ...
Benjamin J, Wildman +5 more
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Biomolecular Concepts, 2020 Human periodontal ligament stem cells (HPDLSCs) are a unique population of mesenchymal stem cells (MSCs). Recently, the positive effects of photobiomodulation on the regulation of MSCs proliferation and osteogenic differentiation have gained significant ...
Abdelgawad Latifa Mohamed +3 more
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