Results 41 to 50 of about 52,415 (197)

Transcriptional program of osteoblast differentiation : coordinated activation of Notch, Wnt, and TGF-[beta] signaling pathways in MC3T3 cell line [PDF]

, 2005
In order to examine the early events in osteoblast differentiation, three different model systems for osteoblast differentiation were compared: mouse pre-osteoblastic cell line MC3T3; mouse myoblastic cell line C2C12 and primary mouse calvarial ...
Zamurovic, Natasa
core   +1 more source

Role and regulation of RUNX2 in osteogenesis

European Cells and Materials, 2014
Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked.
Bruderer M, Richards RG, Alini M, Stoddart MJ   +3 more
openaire   +4 more sources

Runx2 Integrates Estrogen Activity in Osteoblasts [PDF]

Journal of Biological Chemistry, 2003
Steroids significantly effect skeletal integrity. For example, bone mass decreases with glucocorticoid excess or with estrogen depletion after menopause. Glucocorticoid suppresses gene expression by an essential skeletal tissue transcription factor, Runx2, in rat osteoblasts.
Thomas L, McCarthy, Wei-Zhong, Chang, Yuan, Liu, Michael, Centrella   +3 more
openaire   +2 more sources

The transcription factor Runx2 is under circadian control in the suprachiasmatic nucleus and functions in the control of rhythmic behavior. [PDF]

PLoS ONE, 2013
Runx2, a member of the family of runt-related transcription factors, is rhythmically expressed in bone and may be involved in circadian rhythms in bone homeostasis and osteogenesis. Runx2 is also expressed in the brain, but its function is unknown.
Meghan E Reale, Ian C Webb, Xu Wang, Ricardo M Baltazar, Lique M Coolen, Michael N Lehman   +5 more
doaj   +1 more source

Regulatory Effects of O-GlcNAcylation in Vascular Smooth Muscle Cells on Diabetic Vasculopathy

Journal of Lipid and Atherosclerosis, 2020
Vascular complications from uncontrolled hyperglycemia are the leading cause of death in patients with diabetes mellitus. Previous reports have shown a strong correlation between hyperglycemia and vascular calcification, which increases mortality and ...
Chang Hyun Byon, Soo Wan Kim
doaj   +1 more source

Runx2 activates hepatic stellate cells to promote liver fibrosis via transcriptionally regulating Itgav expression

Clinical and Translational Medicine, 2023
Backgrounds and aims As a central event during liver fibrosis, hepatic stellate cells (HSC) have been thought to be a potential therapeutic target for liver fibrosis.
Li Zhong, Jinqiu Zhao, Lu Huang, Yi Liu, Xiaoxiao Pang, Ke Zhan, Shan Li, Qian Xue, Xiaoli Pan, Liang Deng   +9 more
doaj   +1 more source

Talla baja asociada a dientes supernumerarios y anomalías esqueléticas como clave diagnóstica de displasia cleidocraneal en pediatría. Caso clínico.

Revista GICOS
La displasia cleidocraneal (OMIM #119600) es una osteocondrodisplasia de herencia autosómica dominante debida a una mutación en heterocigosis en el gen RUNX2. Su prevalencia es 1 en 1.000.000 individuos.
Nolis Camacho-Camargo, Francisco Cammarata-Scalisi, Gloria Fátima Silva de Arenas, Carmine Lobo-Vielma, Yoselyn Martorelli-Suarez   +4 more
doaj   +1 more source

Association of functionally different RUNX2 P2 promoter alleles with BMD

, 2006
RUNX2 gene SNPs were genotyped in subjects from the upper and lower deciles of age- and weight-adjusted femoral neck BMD. Of 16 SNPs in RUNX2 and its two promoters (P1 and P2), only SNPs in the P2 promoter were significantly associated with BMD. These P2
van Daal, Angela, Day, Christopher, Day, Christopher J., Stephens, Alexandre, Morrison, NA, Carter, SL, Nicholson, Geoff, van Daal, A, Carter, Shea, Kotowicz, MA, Carter, Shea L., Doecke, James D., Kotowicz, Mark A., Nicholson, GC, Stephens, Alexandre S. J., Morrison, Nigel, Morrison, Nigel A., Stephens, ASJ, Nicholson, Geoffrey C., Doecke, James, Kotowicz, Mark, Doecke, JD, Day, CJ   +22 more
core   +1 more source

Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts

PLOS Genetics, 2020
Chondrocytes proliferate and mature into hypertrophic chondrocytes. Vascular invasion into the cartilage occurs in the terminal hypertrophic chondrocyte layer, and terminal hypertrophic chondrocytes die by apoptosis or transdifferentiate into osteoblasts. Runx2 is essential for osteoblast differentiation and chondrocyte maturation. Runx2-deficient mice
Xin Qin, Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Toshihiro Miyazaki, Hisato Komori, Kosei Ito, Klaus von der Mark, Chiharu Sakane, Hitomi Kaneko, Toshihisa Komori   +10 more
openaire   +4 more sources

Inducible regulation of Runx2-stimulated osteogenesis [PDF]

Gene Therapy, 2006
Ex vivo gene therapy is a promising approach to orthopedic regenerative medicine. These strategies typically focus on the constitutive overexpression of osteogenic factors to induce osteoblastic differentiation and matrix mineralization. However, the unregulated production of osteoinductive molecules has also resulted in abnormal bone formation and ...
C A, Gersbach, J M, Le Doux, R E, Guldberg, A J, García   +3 more
openaire   +2 more sources