Results 41 to 50 of about 69,808 (343)

Cleidocranial dysplasia – A case report discussing the clinical and radiological manifestations

Journal of Marine Medical Society, 2020
Cleidocranial dysplasia (CCD) is a generalized skeletal disorder characterized by typical clinical and radiological abnormalities which include open cranial sutures and fontanelle, presence of Wormian bones, characteristic abnormalities of the clavicle ...
Vikram Singh Shekhawat, Yoginder Singh Gulati   +1 more
doaj   +1 more source

Runx2 and dental development

European Journal of Oral Sciences, 2006
The Runx2 gene is a master transcription factor of bone and plays a role in all stages of bone formation. It is essential for the initial commitment of mesenchymal cells to the osteoblastic lineage and also controls the proliferation, differentiation, and maintenance of these cells.
Camilleri, S, McDonald, F
openaire   +3 more sources

Extracellular acidosis suppresses calcification of vascular smooth muscle cells by inhibiting calcium influx via L-type calcium channels

Clinical and Experimental Hypertension, 2018
Vascular calcification such as arteriosclerosis, which is characterized by a calcification of the tunica media, is a severe complication of chronic kidney disease (CKD), contributing to the high prevalence of cardiovascular morbidity and mortality in ...
Shenglei Zhang, Jinsheng Xu, Yu Feng, Junxia Zhang, Liwen Cui, Huiran Zhang, Yaling Bai   +6 more
doaj   +1 more source

Combination treatment of bisphosphonate (pamidronate) and Quercus infectoria semi- purified fraction promotes proliferation and differentiation of osteoblast cell via expression of Osterix and Runx2 marker

Asian Pacific Journal of Tropical Biomedicine, 2018
Objective: To understand the effects of combination treatment of pamidronate with isolated Quercus infectoria semi-purified fraction (QIsm-F) on human foetal osteoblast cell model (hFOB 1.19 cell line) through assessment of Runt related transcription ...
Abdullah Amira Raudhah, Hapidin Hermizi, Abdullah Hasmah   +2 more
doaj   +1 more source

Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1. [PDF]

, 2015
In tumor cells, two factors are abnormally increased that contribute to metastatic bone disease: Runx2, a transcription factor that promotes expression of metastasis related and osteolytic genes; and IL-11, a secreted osteolytic cytokine.
Gillian Browne, Gary S. Stein, Hai Wu, Lucia R. Languino, Dobson, Jason R., Lian, Jane B., Jacqueline Akech, Zhang, Xuhui, Jason R. Dobson, Akech, Jacqueline, Deli Hong, Xuhui Zhang, Browne, Gillian, Jane B. Lian, Hong, Deli, Stein, Gary S., Wu, Hai, Languino, Lucia R.   +17 more
core   +2 more sources

Fibroblast-like Synoviocytes-derived Exosomal PCGEM1 Accelerates IL-1β-induced Apoptosis and Cartilage Matrix Degradation by miR-142-5p/RUNX2 in Chondrocytes

Immunological Investigations, 2021
Background Long non-coding RNA (lncRNA) prostate cancer gene expression marker 1 (PCGEM1) has been revealed to participate in the pathogenesis of osteoarthritis (OA). However, the molecular mechanism of PCGEM1 regulating OA progression has not been fully
Guang-Qiao Zeng, G. Deng, Shi-Liang Xiao, Fei Li   +3 more
semanticscholar   +1 more source

A Potential Role of RUNX2- RUNT Domain in Modulating the Expression of Genes Involved in Bone Metastases: An In Vitro Study with Melanoma Cells

Cells, 2020
Ectopic expression of RUNX2 has been reported in several tumors. In melanoma cells, the RUNT domain of RUNX2 increases cell proliferation and migration.
Michela Deiana, Luca Dalle Carbonare, Michela Serena, Samuele Cheri, Simona Mutascio, Alberto Gandini, Giulio Innamorati, Pamela Lorenzi, Michela Cumerlato, Jessica Bertacco, Franco Antoniazzi, Maria Grazia Romanelli, Monica Mottes, Donato Zipeto, Maria Teresa Valenti   +14 more
doaj   +1 more source

Runx2 is required for hypertrophic chondrocyte mediated degradation of cartilage matrix during endochondral ossification

Matrix Biology Plus, 2021
Highlights • Runx2 loss in hypertrophic chondrocytes (Runx2HC/HC) causes limb dwarfism in mice.• Decreased apoptosis leads to doubling of the zone of hypertrophic chondrocytes.• Runx2HC/HC hypertrophic chondrocytes barely expresses Mmps and aggrecanase.•
Harunur Rashid, Haiyan Chen, A. Javed
semanticscholar   +1 more source

Immunocytochemistry and western blot test for the in-situ detection of biomarkers of osteogenesis

Scientific Dental Journal, 2022
There are two ways that bones can form: intramembranous and endochondral ossification. Specific osteogenic markers, such as insulin-like growth factor (IGF-1), osteocalcin (OCN), Runt-related transcription factor 2 (RUNX2), and osterix (OSX), accompany ...
Priska Natassya, Endang Winiati Bachtiar
doaj   +1 more source

HDAC6 inactivates Runx2 promoter to block osteogenesis of bone marrow stromal cells in age-related bone loss of mice

Stem cell research & therapeutics, 2021
Senile osteoporosis can cause bone fragility and increased risk for fractures and has been one of the most prevalent and severe diseases affecting the elderly population worldwidely.
Chao Ma, Juan Gao, Jun Liang, Wei-Xiang Dai, Zhenfei Wang, Mengjiao Xia, Taoyi Chen, Sen Huang, Jian Na, Long Xu, Shiming Feng, K. Dai, Guang-Wang Liu   +12 more
semanticscholar   +1 more source