Results 41 to 50 of about 41,144 (263)
A Runx2 threshold for the cleidocranial dysplasia phenotype [PDF]
Human Molecular Genetics, 2008 Cleidocranial dysplasia (CCD) in humans is an autosomal-dominant skeletal disease that results from mutations in the bone-specific transcription factor RUNX2 (CBFA1/AML3). However, distinct RUNX2 mutations in CCD do not correlate with the severity of the disease.
Lou, Yang +12 more
openaire +3 more sources
Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids. [PDF]
PLoS ONE, 2014 The Runt-related transcription factor 2 (Runx2) gene encodes the transcription factor Runx2, which is the master regulator of osteoblast development; insufficiency of this protein causes disorders of bone development such as cleidocranial dysplasia ...
Hideaki Okura +7 more
doaj +1 more source
RUNX2 as a promising therapeutic target for malignant tumors
Cancer Management and Research, 2021 Weizhu Zhao,1,2 Haiying Yang,3 Jie Chai,4 Ligang Xing1 1Department of Radiology, Cancer Hospital Affiliated to Shandong First Medical University, Shandong Cancer Hospital and Institute, Jinan, 250117, People’s Republic of China; 2Department of ...
Zhao W, Yang H, Chai J, Xing L
doaj
The transcription factor Runx2 is under circadian control in the suprachiasmatic nucleus and functions in the control of rhythmic behavior. [PDF]
PLoS ONE, 2013 Runx2, a member of the family of runt-related transcription factors, is rhythmically expressed in bone and may be involved in circadian rhythms in bone homeostasis and osteogenesis. Runx2 is also expressed in the brain, but its function is unknown.
Meghan E Reale +5 more
doaj +1 more source
Role and regulation of RUNX2 in osteogenesis
European Cells and Materials, 2014 Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked.
Bruderer M +3 more
openaire +4 more sources
Clinical and Translational Medicine, 2023 Backgrounds and aims As a central event during liver fibrosis, hepatic stellate cells (HSC) have been thought to be a potential therapeutic target for liver fibrosis.
Li Zhong +9 more
doaj +1 more source
Inducible regulation of Runx2-stimulated osteogenesis [PDF]
Gene Therapy, 2006 Ex vivo gene therapy is a promising approach to orthopedic regenerative medicine. These strategies typically focus on the constitutive overexpression of osteogenic factors to induce osteoblastic differentiation and matrix mineralization. However, the unregulated production of osteoinductive molecules has also resulted in abnormal bone formation and ...
C A, Gersbach +3 more
openaire +2 more sources
Identification of the hub genes RUNX2 and FN1 in gastric cancer
Open Medicine, 2020 This study identified key genes in gastric cancer (GC) based on the mRNA microarray GSE19826 from the Gene Expression Omnibus (GEO) database and preliminarily explored the relationships among the key genes.
Han Chao +5 more
doaj +1 more source
Aqueous Two‐Phase Bioinks for Discrete Packing and Compartmentalization of 3D Bioprinted Cells
Advanced Healthcare Materials, EarlyView.Aqueous two‐phase systems (ATPS) enable the formation of biomimetic interfaces crucial for tissue engineering. However, clinical translation remains limited by the challenge of precisely controlling cellular compartmentalization. Here, we developed ATPS biomaterial inks for 3D bioprinting allowing tuneable droplet formation via NaCl modulation.
Martina Marcotulli +17 more
wiley +1 more source
Revista GICOSLa displasia cleidocraneal (OMIM #119600) es una osteocondrodisplasia de herencia autosómica dominante debida a una mutación en heterocigosis en el gen RUNX2. Su prevalencia es 1 en 1.000.000 individuos.
Nolis Camacho-Camargo +4 more
doaj +1 more source