Results 21 to 30 of about 52,415 (197)

Runx2 rs59983488 polymorphism in class II malocclusion in the Indonesian subpopulation

Dental Journal, 2021
Background: Class II malocclusion is one of the main orthodontic issues for patients in seeking treatment. The prevalence of class II malocclusion varies in different populations.
Fadli Jazaldi, Benny M. Soegiharto, Astrid Dinda Hutabarat, Noertami Soedarsono, Elza Ibrahim Auerkari   +4 more
doaj   +1 more source

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice [PDF]

, 2010
Nearly every extracellular ligand that has been found to play a role in regulating bone biology acts, at least in part, through MAPK pathways. Nevertheless, much remains to be learned about the contribution of MAPKs to osteoblast biology in vivo. Here we
Zhai, Bo, Weiguo Zou, Shim, Jae-Hyuck, Hu, Dorothy, Lotinun, Sutada, Glimcher, Laurie H., Arthur, Simon; id_orcid, Michael D. Schneider, Yasuyo Sano, Min Xie, Matthew B. Greenblatt, Laurie H. Glimcher, Jae-Hyuck Shim, Roger Davis, Xie, Min, Sano, Yasuyo, Despina Sitara, Schweitzer, Michelle, Park, Jin Mo, Schneider, Michael D., Gygi, Steven, Greenblatt, Matthew B., Baron, Roland, Simon Arthur, Zou, Weiguo, Jin Mo Park, Michelle Schweitzer, Davis, Roger, Roland Baron, Sitara, Despina, Sutada Lotinun, Dorothy Hu, Bo Zhai, Steven Gygi   +33 more
core   +1 more source

KLF2 reduces dexamethasone-induced injury to growth plate chondrocytes by inhibiting the Runx2-mediated PI3K/AKT and ERK signalling pathways

Autoimmunity, 2023
Dexamethasone (Dex) is a type of glucocorticoid drug. Long term use can induce growth plate chondrocytes (GPCs) apoptosis, impair differentiation, and inhibit cell proliferation and bone growth.
Yulong Ma, Tao Peng, Xudong Yao, Chaonan Sun, Xiaowei Wang   +4 more
doaj   +1 more source

Runx2 and dental development

European Journal of Oral Sciences, 2006
The Runx2 gene is a master transcription factor of bone and plays a role in all stages of bone formation. It is essential for the initial commitment of mesenchymal cells to the osteoblastic lineage and also controls the proliferation, differentiation, and maintenance of these cells.
Camilleri, S, McDonald, F
openaire   +3 more sources

Extracellular acidosis suppresses calcification of vascular smooth muscle cells by inhibiting calcium influx via L-type calcium channels

Clinical and Experimental Hypertension, 2018
Vascular calcification such as arteriosclerosis, which is characterized by a calcification of the tunica media, is a severe complication of chronic kidney disease (CKD), contributing to the high prevalence of cardiovascular morbidity and mortality in ...
Shenglei Zhang, Jinsheng Xu, Yu Feng, Junxia Zhang, Liwen Cui, Huiran Zhang, Yaling Bai   +6 more
doaj   +1 more source

Combination treatment of bisphosphonate (pamidronate) and Quercus infectoria semi- purified fraction promotes proliferation and differentiation of osteoblast cell via expression of Osterix and Runx2 marker

Asian Pacific Journal of Tropical Biomedicine, 2018
Objective: To understand the effects of combination treatment of pamidronate with isolated Quercus infectoria semi-purified fraction (QIsm-F) on human foetal osteoblast cell model (hFOB 1.19 cell line) through assessment of Runt related transcription ...
Abdullah Amira Raudhah, Hapidin Hermizi, Abdullah Hasmah   +2 more
doaj   +1 more source

Influence of photobiomodulation and vitamin D on osteoblastic differentiation of human periodontal ligament stem cells and bone-like tissue formation through enzymatic activity and gene expression

Biomolecular Concepts, 2020
Human periodontal ligament stem cells (HPDLSCs) are a unique population of mesenchymal stem cells (MSCs). Recently, the positive effects of photobiomodulation on the regulation of MSCs proliferation and osteogenic differentiation have gained significant ...
Abdelgawad Latifa Mohamed, Abdelaziz Asmaa Mohamed, Sabry Dina, Abdelgwad Marwa   +3 more
doaj   +1 more source

LncRNA MYCNOS promotes prostate cancer cell proliferation by regulating the miR-466/RUNX2 axis

Journal of Biological Research - Thessaloniki, 2022
The function of lncRNA MYCNOS has only been reported in hepatocellular carcinoma. We studied the role of MYCNOS in prostate cancer (PC). In this study, MYCNOS expression in tissue samples from 64 PC patients was studied by RT-qPCR. Base pairing formed by
Guiliu Chen, Chao Tian, Chongwei Xie, Zhengguo Cao   +3 more
doaj   +1 more source

Differentiation of mesenchymal stem cells isolated from the amniotic membrane and umbilical cord to osteocytes and the expression of RunX2, Osteonectin, ALP genes

Journal of Current Biomedical Reports, 2022
Mesenchymal stem cells (MSCs) are multipotent cells and able to differentiate into connective tissues such as bone, fat, cartilage, tendon, and muscle. They show to be very potent tools for tissue engineering and regenerative medicine. Several researches
Nooshin Barikrow, Amin Tabasi
doaj   +1 more source

Identification of the hub genes RUNX2 and FN1 in gastric cancer

Open Medicine, 2020
This study identified key genes in gastric cancer (GC) based on the mRNA microarray GSE19826 from the Gene Expression Omnibus (GEO) database and preliminarily explored the relationships among the key genes.
Han Chao, Jin Lei, Ma Xuemei, Hao Qin, Lin Huajun, Zhang Zhongtao   +5 more
doaj   +1 more source