Results 21 to 30 of about 69,808 (343)

The effect of different intensities Resistance Training on expression mir-204 and transcription factors of osteogenic, Runx2 and biomechanical properties on bone in Old male Wistar rats [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2021
Purpose:  Bones are largely influenced by nutrition, activity levels and lifestyle, and structural adaptations in the form and size of the bone occur by the forces of weight bearing and forces applied by the muscles.
ZAHRA HEMATI FARSANI, Ebrahim Banitalebi, Mohamad Faramarzi, Amin Bigham-Sadegh   +3 more
doaj   +1 more source

The Role of RUNX2 in Osteosarcoma Oncogenesis [PDF]

Sarcoma, 2011
Osteosarcoma is an aggressive but ill-understood cancer of bone that predominantly affects adolescents. Its rarity and biological heterogeneity have limited studies of its molecular basis. In recent years, an important role has emerged for the RUNX2 “platform protein” in osteosarcoma oncogenesis. RUNX proteins are DNA-binding transcription factors that
Martin, J. W., Zielenska, M., Stein, G. S., van Wijnen, A. J., Squire, J. A.   +4 more
openaire   +3 more sources

Emerging RUNX2-Mediated Gene Regulatory Mechanisms Consisting of Multi-Layered Regulatory Networks in Skeletal Development

International Journal of Molecular Sciences, 2023
Skeletal development is tightly coordinated by chondrocytes and osteoblasts, which are derived from skeletal progenitors, and distinct cell-type gene regulatory programs underlie the specification and differentiation of cells.
H. Hojo
semanticscholar   +1 more source

RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis

Cell Death and Differentiation, 2022
Runt-related transcription factor 2 (RUNX2) is an osteogenesis-related transcription factor that has emerged as a prominent transcription repressing factor in carcinogenesis.
Xin Yin, Xu Teng, Tian-Yu Ma, Tian-Shu Yang, Jing-Yao Zhang, Miao-Miao Huo, Wei Liu, Yunkai Yang, Bao-Wen Yuan, Hefen Yu, Wei Huang, Yan Wang   +11 more
semanticscholar   +1 more source

BEL β-Trefoil Reduces the Migration Ability of RUNX2 Expressing Melanoma Cells in Xenotransplanted Zebrafish

Molecules, 2020
RUNX2, a master osteogenic transcript ion factor, is overexpressed in several cancer cells; in melanoma it promotes cells migration and invasion as well as neoangiogenesis.
Maria Teresa Valenti, Giulia Marchetto, Massimiliano Perduca, Natascia Tiso, Monica Mottes, Luca Dalle Carbonare   +5 more
doaj   +1 more source

Runx2 rs59983488 polymorphism in class II malocclusion in the Indonesian subpopulation

Dental Journal, 2021
Background: Class II malocclusion is one of the main orthodontic issues for patients in seeking treatment. The prevalence of class II malocclusion varies in different populations.
Fadli Jazaldi, Benny M. Soegiharto, Astrid Dinda Hutabarat, Noertami Soedarsono, Elza Ibrahim Auerkari   +4 more
doaj   +1 more source

SIRT6 protects vascular smooth muscle cells from osteogenic transdifferentiation via Runx2 in chronic kidney disease

Journal of Clinical Investigation, 2021
Vascular calcification (VC) is regarded as an important pathological change lacking effective treatment and associated with high mortality. Sirtuin 6 (SIRT6) is a member of the Sirtuin family, a class III histone deacetylase and a key epigenetic ...
Wen-Xin Li, Weijing Feng, Xiao-Yan Su, Dongling Luo, Zhi-Bing Li, Yongqiao Zhou, Yong-Jun Zhu, Meng-Bi Zhang, Jie Chen, Bao-Hua Liu, Hui Huang   +10 more
semanticscholar   +1 more source

Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages

Cell Reports, 2022
SUMMARY The transcriptional regulator Runx2 (runt-related transcription factor 2) has essential but distinct roles in osteoblasts and chondrocytes in skeletal development.
H. Hojo, Taku Saito, X. He, Qiu-Yu Guo, Shoko Onodera, Toshifumi Azuma, M. Koebis, K. Nakao, A. Aiba, M. Seki, Yutaka Suzuki, H. Okada, Sakae Tanaka, U. Chung, Andrew P. McMahon, Shinsuke Ohba   +15 more
semanticscholar   +1 more source

ac4C acetylation of RUNX2 catalyzed by NAT10 spurs osteogenesis of BMSCs and prevents ovariectomy-induced bone loss

Molecular Therapy: Nucleic Acids, 2021
N-acetyltransferase 10 (NAT10) is the key enzyme for N4-acetylcytidine (ac4C) modification of mRNA, which participates in various cellular processes and is related to many diseases.
W. Yang, H.-Y. Li, Y.-F. Wu, Rujia Mi, W.-Z. Liu, X. Shen, Yi-Xuan Lu, Y.H. Jiang, Meng-Jun Ma, H.-Y. Shen   +9 more
semanticscholar   +1 more source

LncRNA MYCNOS promotes prostate cancer cell proliferation by regulating the miR-466/RUNX2 axis

Journal of Biological Research - Thessaloniki, 2022
The function of lncRNA MYCNOS has only been reported in hepatocellular carcinoma. We studied the role of MYCNOS in prostate cancer (PC). In this study, MYCNOS expression in tissue samples from 64 PC patients was studied by RT-qPCR. Base pairing formed by
Guiliu Chen, Chao Tian, Chongwei Xie, Zhengguo Cao   +3 more
doaj   +1 more source