Results 51 to 60 of about 69,808 (343)

Regulatory Effects of O-GlcNAcylation in Vascular Smooth Muscle Cells on Diabetic Vasculopathy

Journal of Lipid and Atherosclerosis, 2020
Vascular complications from uncontrolled hyperglycemia are the leading cause of death in patients with diabetes mellitus. Previous reports have shown a strong correlation between hyperglycemia and vascular calcification, which increases mortality and ...
Chang Hyun Byon, Soo Wan Kim
doaj   +1 more source

Comparison Between RunX2 and Osteocalcin Expression Following the Application of Demineralized Freeze-Dried Bone Xenograft (DBFX) and Bovine Hydroxyapatite (BHA) and Their Effect on Bone Defect (In vivo Laboratory Experiment)

Journal of Stem Cell Research and Tissue Engineering, 2022
The use of biomaterial such as bone graft material is highly needed in oral and maxillofacial surgery to overcome bone defect that happened due to various reasons. One of the bone graft that widely used is bovine hydroxyapatite (BHA).
Ikhram Kharis
doaj   +1 more source

RUNX2 (6p21.1) amplification in osteosarcoma

Human Pathology, 2019
Prior cytogenetic profiling of osteosarcomas has suggested that amplifications at the 6p12-21 locus are relatively common alterations in these tumors. However, these studies have been limited by variable testing methodologies used as well as by the relatively small numbers of cases that have been analyzed.
Sounak, Gupta, Tatsuo, Ito, Deepu, Alex, Chad M, Vanderbilt, Jason C, Chang, Nasrin, Islamdoust, Yanming, Zhang, Khedoudja, Nafa, John, Healey, Marc, Ladanyi, Meera R, Hameed   +10 more
openaire   +3 more sources

The transcription factor RUNX2 fuels YAP1 signaling and gastric cancer tumorigenesis

Cancer Science, 2021
Despite considerable efforts in the detection and treatment of gastric cancer (GC), the underlying mechanism of the progression of GC remains unknown. Our previous work has demonstrated the remarkable role of Runt‐related transcription factor 2 (RUNX2 ...
Zheng-Jun Guo, Kai Zhou, Qiang Wang, Yu-Sheng Huang, J. Ji, Yuan Peng, Xiaoyue Zhang, Taihao Zheng, Zhen Zhang, Dao-Chen Chong, Zhenzhou Yang   +10 more
semanticscholar   +1 more source

MICROmanagement of Runx2 Function in Skeletal Cells [PDF]

Current Molecular Biology Reports, 2019
Precise and temporal expression of Runx2 and its regulatory transcriptional network is a key determinant for the intricate cellular and developmental processes in adult bone tissue formation. This review analyzes how microRNA functions to regulate this network, and how dysregulation results in bone disorders.Similar to other biologic processes ...
Benjamin J, Wildman, Tanner C, Godfrey, Mohammad, Rehan, Yuechuan, Chen, Lubana H, Afreen, Quamarul, Hassan   +5 more
openaire   +2 more sources

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia.

Journal of Clinical Investigation, 2021
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared to B-cell ALL. Here, we showed that Runt-related transcription factor 2, RUNX2 was upregulated in high-risk T-ALL with KMT2A rearrangements
F. Matthijssens, Nitesh D. Sharma, Monique Nysus, C. Nickl, Hui-Ning Kang, Dominique R. Perez, B. Lintermans, W. Van Loocke, J. Roels, Sofie Peirs, L. Demoen, T. Pieters, Lindy Reunes, T. Lammens, B. De Moerloose, F. van Nieuwerburgh, D. Deforce, Laurence C. Cheung, R. Kotecha, Martijn Risseeuw, S. van Calenbergh, T. Takarada, Y. Yoneda, Frederik W. van Delft, R. Lock, Seth D. Merkley, A. Chigaev, L. Sklar, C. Mullighan, M. Loh, S. Winter, S. Hunger, S. Goossens, Eliseo F. Castillo, Wojciech Ornatowski, P. Van Vlierberghe, K. Matlawska-Wasowska   +36 more
semanticscholar   +1 more source

Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-beta and Runx2 in bone is required for hearing [PDF]

, 2010
Publisher version: http://www.nature.com/embor/journal/v11/n10/full/embor2010135.htmlDA - 20100917 IS - 1469-3178 (Electronic) IS - 1469-221X (Linking) LA - ENG PT - JOURNAL ARTICLEDA - 20100917 IS - 1469-3178 (Electronic) IS - 1469-221X (Linking) LA ...
Anil Lalwani, Chin, EN, Carol G Chen, Derynck, R, Marshall, GW, Butcher, K, Guive Balooch, Lawrence Lustig, Akil, O, Porter, AE, Robert O Ritchie, Grayson W Marshall, Jacob Johnson, Lalwani, A, Sally J Marshall, Omar Akil, Emily N Chin, Balooch, G, Humphrey, MB, Lustig, L, Delia S Brauer, Rik Derynck, Kristin Butcher, Marshall, SJ, Richard A Schneider, Tamara Alliston, Alliston, T, Chen, CG, Johnson, J, Jolie L Chang, Brauer, DS, Alexandra E Porter, Schneider, RA, Chang, JL, Ritchie, RO, Mary Beth Humphrey   +35 more
core   +1 more source

RUNX2 mutations in cleidocranial dysplasia

Genetics and Molecular Research, 2013
The runt-related transcription factor 2 gene (RUNX2), which is also known as CBFA1, is a master regulatory gene in bone formation. Mutations in RUNX2 have been identified in cleidocranial dysplasia (CCD) patients. CCD is a rare autosomal dominant skeletal dysplasia that is characterized by delayed closure of cranial sutures, aplastic or hypoplastic ...
K-E, Lee, F, Seymen, J, Ko, M, Yildirim, E B, Tuna, K, Gencay, J-W, Kim   +6 more
openaire   +2 more sources

Carbon Monoxide Releasing Molecule-3 Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Carbon Monoxide Release

Drug Design, Development and Therapy, 2021
Hui Chen,1,2 Yan Dai,1,3 Jing Cui,4 Xiaochun Yin,2 Wei Feng,2 Meiyi lv,1,5 Hui Song1 1Department of VIP Center, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration
Chen H, Dai Y, Cui J, Yin X, Feng W, lv M, Song H   +6 more
doaj  

KLF2 reduces dexamethasone-induced injury to growth plate chondrocytes by inhibiting the Runx2-mediated PI3K/AKT and ERK signalling pathways

Autoimmunity, 2023
Dexamethasone (Dex) is a type of glucocorticoid drug. Long term use can induce growth plate chondrocytes (GPCs) apoptosis, impair differentiation, and inhibit cell proliferation and bone growth.
Yulong Ma, Tao Peng, Xudong Yao, Chaonan Sun, Xiaowei Wang   +4 more
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