, 2006 Several homeodomain (HD) proteins are critical for skeletal patterning and respond directly to BMP2 as an early step in bone formation. RUNX2, the earliest transcription factor proven essential for commitment to osteoblastogenesis, is also expressed in ...
Aberg +71 more
core +1 more source
Histological and immunohistochemical evaluation of mandibular bone tissue regeneration [PDF]
, 2018 The purpose of the study was to perform an immunohistochemical and histological evaluation of samples taken from different bone regeneration procedures in atrophic human mandible.
Brauner, E +8 more
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Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids. [PDF]
PLoS ONE, 2014 The Runt-related transcription factor 2 (Runx2) gene encodes the transcription factor Runx2, which is the master regulator of osteoblast development; insufficiency of this protein causes disorders of bone development such as cleidocranial dysplasia ...
Hideaki Okura +7 more
doaj +1 more source
MicroRNA-433 Dampens Glucocorticoid Receptor Signaling, Impacting Circadian Rhythm and Osteoblastic Gene Expression [PDF]
, 2016 FUNDING This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [AR44877]; the National Institutes for Dental and Craniofacial Research [5T90DE21989]; a Grant-in-Aid award ...
Delany, Anne M +4 more
core +1 more source
RUNX2 as a promising therapeutic target for malignant tumors
Cancer Management and Research, 2021 Weizhu Zhao,1,2 Haiying Yang,3 Jie Chai,4 Ligang Xing1 1Department of Radiology, Cancer Hospital Affiliated to Shandong First Medical University, Shandong Cancer Hospital and Institute, Jinan, 250117, People’s Republic of China; 2Department of ...
Zhao W, Yang H, Chai J, Xing L
doaj
The transcription factor Runx2 is under circadian control in the suprachiasmatic nucleus and functions in the control of rhythmic behavior. [PDF]
PLoS ONE, 2013 Runx2, a member of the family of runt-related transcription factors, is rhythmically expressed in bone and may be involved in circadian rhythms in bone homeostasis and osteogenesis. Runx2 is also expressed in the brain, but its function is unknown.
Meghan E Reale +5 more
doaj +1 more source
Local origins impart conserved bone type-related differences in human osteoblast behaviour [PDF]
, 2015 Osteogenic behaviour of osteoblasts from trabecular, cortical and subchondral bone were examined to determine any bone type-selective differences in samples from both osteoarthritic (OA) and osteoporotic (OP) patients.
Clarkin, C E +6 more
core +3 more sources
CTRP13 attenuates vascular calcification by regulating Runx2 [PDF]
The FASEB Journal, 2019 ABSTRACT Vascular calcification is strongly associated with increased cardiovascular mortality and morbidity. C1q/ TNF‐related protein‐13 (CTRP13) is a secreted adipokine that plays important roles in the cardiovascular system. However, the functional role of CTRP13 in the development of vascular calcification has
Yongxia, Li +4 more
openaire +2 more sources
Clinical and Translational Medicine, 2023 Backgrounds and aims As a central event during liver fibrosis, hepatic stellate cells (HSC) have been thought to be a potential therapeutic target for liver fibrosis.
Li Zhong +9 more
doaj +1 more source
Identification of the hub genes RUNX2 and FN1 in gastric cancer
Open Medicine, 2020 This study identified key genes in gastric cancer (GC) based on the mRNA microarray GSE19826 from the Gene Expression Omnibus (GEO) database and preliminarily explored the relationships among the key genes.
Han Chao +5 more
doaj +1 more source