Results 51 to 60 of about 52,415 (197)

Smad6 Interacts with Runx2 and Mediates Smad Ubiquitin Regulatory Factor 1-induced Runx2 Degradation [PDF]

Journal of Biological Chemistry, 2006
Runx2 is a bone-specific transcription factor that plays a critical role in bone development, postnatal bone formation, and chondrocyte maturation. The protein levels of Runx2 are regulated by the ubiquitin-proteasome pathway. In previous studies we discovered that E3 ubiquitin ligase Smad ubiquitin regulatory factor 1 (Smurf1) induces Runx2 ...
Run, Shen, Mo, Chen, Yong-Jun, Wang, Hiroyuki, Kaneki, Lianping, Xing, Regis J, O'keefe, Di, Chen   +6 more
openaire   +2 more sources

CircRNA_102272 Promotes Cisplatin-Resistance in Hepatocellular Carcinoma by Decreasing MiR-326 Targeting of RUNX2

Cancer Management and Research, 2020
Yonghai Guan,1,* Ying Zhang,2,* Lina Hao,3 Zhenwang Nie1 1Department of Infectious Diseases, The Second Hospital of Dalian Medical University, Dalian 116023, Liaoning, People’s Republic of China; 2Sixth Department of Liver Diseases, The Sixth ...
Guan Y, Zhang Y, Hao L, Nie Z
doaj  

RUNX2 Reverses p53-Induced Chemotherapy Resistance in Gastric Cancer

Pharmacogenomics and Personalized Medicine, 2023
Yuan Huang,1 Lu Liang,2 Yong-Xiang Zhao,3 Bi-Hui Yao,2 Rui-Min Zhang,3 Lei Song,2 Zhong-Tao Zhang1 1Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People’s Republic of China; 2Department of ...
Huang Y, Liang L, Zhao YX, Yao BH, Zhang RM, Song L, Zhang ZT   +6 more
doaj  

Runx2-I was expressed in Runx2-I^TGA/TGA mice as N-terminal truncated Runx2.

, 2014
(A) Anti-Runx2 mAb (clone: 8G5) could recognize Runx2-II, Runx2-I, and their truncated versions. HEK293 cells were transiently transfected with the indicated expression vectors (see Materials and Methods).
Tomoki Nakashima (632614), Hiroshi Takayanagi (261902), Shintaro Sato (268347), Nobuaki Yoshida (111039), Hiroshi Kiyono (69959), Hideaki Okura (632611), Satoshi Kaneto (632613), Sari Kishikawa (632612)   +7 more
core   +1 more source

Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter [PDF]

, 2005
Two major isoforms of the Runx2 gene are expressed by alternative promoter usage: Runx2 type I (Runx2-I) is derived from the proximal promoter (P2), and Runx2 type II (Runx2-II) is produced by the distal promoter (P1).
Hwang, Yoo-Seok, Cho, Je-Yoel, Kim, Jee-In, Kim, Byung-Gyu, Bae, Suk-Chul, Kim, Youn-Jeong, Yoon, Won-Joon, Chi, Xin-Zi, Lee, Mi-Hye, Wozney, John M., Choi, Je-Yong, Choi, Kang-Young, Ryoo, Hyun-Mo   +12 more
core   +1 more source

Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 gene [PDF]

Journal of Cellular Physiology, 2012
AbstractEpigenetic mechanisms mediating expression of the Runt‐related transcription factor Runx2 are critical for controlling its osteogenic activity during skeletal development. Here, we characterized bona fide regulatory elements within 120 kbp of the endogenous bone‐related Runx2 promoter (P1) in osteoblasts by genomic DNase I footprinting and ...
Hovhannisyan, Hayk, Zhang, Ying, Hassan, Mohammad Q., Wu, Hai, Glackin, Carlotta, Lian, Jane B., Stein, Janet L., Montecino, Martin A., Stein, Gary S., Van Wijnen, Andre J.   +9 more
openaire   +3 more sources

RUNX2 as a promising therapeutic target for malignant tumors

Cancer Management and Research, 2021
Weizhu Zhao,1,2 Haiying Yang,3 Jie Chai,4 Ligang Xing1 1Department of Radiology, Cancer Hospital Affiliated to Shandong First Medical University, Shandong Cancer Hospital and Institute, Jinan, 250117, People’s Republic of China; 2Department of ...
Zhao W, Yang H, Chai J, Xing L
doaj  

Cbfβ regulates Runx2 function isoform-dependently in postnatal bone development [PDF]

, 2006
Runx2 and Cbfβ are essential for skeletal development during the embryonic stage. Runx2 has two isoforms with different N-termini. We examined the functions of the Runx2 isoforms and Cbfβ in postnatal bone development.
Fukuyama, Ryo, Liu, Wenguang, Moriishi, Takeshi, Miyazaki, Toshihiro, Yamana, Kei, Kanatani, Naoko, Komori, Toshihisa, Fujita, Takashi, Toyosawa, Satoru, Yoshida, Carolina A.   +9 more
core   +1 more source

RANKL, OPG, and RUNX2 expression and epigenetic modifications in giant cell tumour of bone in 32 patients: association with clinicopathological characteristics and recurrence

Bone & Joint Research
Aims: The present study investigated receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG), and Runt-related transcription factor 2 (RUNX2) gene expressions in giant cell tumour of bone (GCTB) patients in relationship with ...
Raja Amri, Ameni Chelly, Mariem Ayedi, Mohammed A. Rebaii, Sami Aifa, Sabeur Masmoudi, Hassib Keskes   +6 more
doaj   +1 more source

Functional cooperation between vitamin D receptor and Runx2 in vitamin D-induced vascular calcification. [PDF]

PLoS ONE, 2013
The transdifferentiation of vascular smooth muscle cells (VSMCs) into osteoblast-like cells has been implicated in the context of vascular calcification. We investigated the roles of vitamin D receptor (Vdr) and runt-related transcription factor 2 (Runx2)
Min-Su Han, Xiangguo Che, Gyoung-ho Cho, Hye-Ri Park, Kyung-Eun Lim, Na-Rae Park, Jung-Sook Jin, Youn-Kwan Jung, Jae-Hwan Jeong, In-Kyu Lee, Shigeaki Kato, Je-Yong Choi   +11 more
doaj   +1 more source