Results 71 to 80 of about 41,144 (263)

SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2. [PDF]

PLoS ONE, 2017
Activation of SIRT1 has previously been shown to protect mice against osteoporosis through yet ill-defined mechanisms. In this study, we outline a role for SIRT1 as a positive regulator of the master osteoblast transcription factor, RUNX2.
Kayvan Zainabadi, Cassie J Liu, Leonard Guarente   +2 more
doaj   +1 more source

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Antagonistic Functions of USAG-1 and RUNX2 during Tooth Development. [PDF]

PLoS ONE, 2016
Supernumerary teeth and tooth agenesis are common morphological anomalies in humans. We previously obtained evidence that supernumerary maxillary incisors form as a result of the successive development of the rudimentary maxillary incisor tooth germ in ...
Yumiko Togo, Katsu Takahashi, Kazuyuki Saito, Honoka Kiso, Hiroko Tsukamoto, Boyen Huang, Motoko Yanagita, Manabu Sugai, Hidemitsu Harada, Toshihisa Komori, Akira Shimizu, Mary MacDougall, Kazuhisa Bessho   +12 more
doaj   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Specific Residues of RUNX2 Are Obligatory for Formation of BMP2-Induced RUNX2-SMAD Complex to Promote Osteoblast Differentiation [PDF]

Cells Tissues Organs, 2008
BMP2 signaling and RUNX2 regulatory pathways converge for transcriptional control of bone formation in vivo. SMAD proteins are recruited to RUNX2 regulatory complexes via an overlapping nuclear matrix targeting signal/Smad interacting domain sequence (391–432) in Runx2.
Javed, Amjad, Afzal, Faiza, Bae, Jong-Sup, Gutierrez, Soraya E., Zaidi, Kaleem, Pratap, Jitesh, Van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Lian, Jane B.   +9 more
openaire   +3 more sources

Primary extraskeletal osteosarcoma of the omentum in a young dog

Brazilian Journal of Veterinary Pathology
Extraskeletal osteosarcoma (EOSA) is a rare and aggressive mesenchymal neoplasm in dogs, primarily affecting older animals, with the spleen being the most common site of involvement.
João Pedro Sanches de Ávila, André Gustavo Alves Holanda, Caroline Cristine Ferreira Mazula, João Antônio Ulhôa Oliveira, Fernanda Gosuen Gonçalves Dias, Pâmela Rodrigues Reina Moreira, Denner Santos dos Anjos   +6 more
doaj   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Long non-coding RNAs in bone formation: Key regulators and therapeutic prospects

Open Life Sciences
Recent scientific investigations have revealed the intricate mechanisms underlying bone formation, emphasizing the essential role of long non-coding RNAs (lncRNAs) as critical regulators.
Jiang Chun, Wang Peng, Tan ZhenWei, Zhang Yin   +3 more
doaj   +1 more source

CircRNA_102272 Promotes Cisplatin-Resistance in Hepatocellular Carcinoma by Decreasing MiR-326 Targeting of RUNX2

Cancer Management and Research, 2020
Yonghai Guan,1,* Ying Zhang,2,* Lina Hao,3 Zhenwang Nie1 1Department of Infectious Diseases, The Second Hospital of Dalian Medical University, Dalian 116023, Liaoning, People’s Republic of China; 2Sixth Department of Liver Diseases, The Sixth ...
Guan Y, Zhang Y, Hao L, Nie Z
doaj  

HDACs control RUNX2 expression in cancer cells through redundant and cell context-dependent mechanisms

Journal of Experimental & Clinical Cancer Research, 2019
Background RUNX2 is a Runt-related transcription factor required during embryogenesis for skeletal development and morphogenesis of other organs including thyroid and breast gland.
Gloria Manzotti, Federica Torricelli, Benedetta Donati, Valentina Sancisi, Mila Gugnoni, Alessia Ciarrocchi   +5 more
doaj   +1 more source