Results 71 to 80 of about 52,415 (197)

Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2

, 2008
RUNX/AML transcription factors are critical regulators of cell growth and differentiation in multiple lineages and have been linked to human cancers including acute myelogenous leukemia (RUNX1), as well as breast (RUNX2) and gastric cancers (RUNX3). RUNX
Lian, Jane B., Rajgopal, Arun, Redick, Sambra D., Young, Daniel W., Stein, Janet L., Mujeeb, Khwaja A., Javed, Amjad, Van Wijnen, Andre J., Doxsey, Stephen J., Pockwinse, Shirwin M., Stein, Gary S., Nickerson, Jeffrey A.   +11 more
core   +1 more source

Role of the RUNX2 p.R225Q mutation in cleidocranial dysplasia: a rare presentation and an analysis of the RUNX2 protein structure

Genetics and Molecular Research, 2014
Cleidocranial dysplasia (CCD; MIM 119600) is an autosomal dominant hereditary disorder of skeletal features whose characteristic clinical symptoms are caused by mutations in the RUNX2 gene. Varying degrees of clavicular hypoplasia and dental abnormalities are the most prominent features of this disorder.
L Z, Wu, W Q, Su, Y F, Liu, X, Ge, Y, Zhang, X J, Wang   +5 more
openaire   +2 more sources

RUNX2 Plays An Oncogenic Role in Esophageal Carcinoma by Activating the PI3K/AKT and ERK Signaling Pathways

Cellular Physiology and Biochemistry, 2018
Background/Aims: Esophageal carcinoma is a frequently occurring cancer at upper gastrointestinal tract. We aimed to evaluate the roles and possible mechanism of Runt Related Transcription Factor 2 (RUNX2) in the development of esophageal cancer. Methods:
Huibin Lu, Tian Jiang, Kewei Ren, Zongming Li Li, Jianzhuang Ren, Gang Wu, Xinwei Han   +6 more
doaj   +1 more source

Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells

Molecular Cancer, 2012
Background The Runt-related transcription factor Runx2 is essential for bone development but is also implicated in progression of several cancers of breast, prostate and bone, where it activates cancer-related genes and promotes invasive properties.
Tandon Manish, Gokul Karthiga, Ali Syed A, Chen Zujian, Lian Jane, Stein Gary S, Pratap Jitesh   +6 more
doaj   +1 more source

RUNX2 promueve la progresión tumor en osteosarcoma [PDF]

, 2011
Magíster en ciencias médicas, mención biología celularEl Osteosarcoma (OS) es el tumor sólido maligno más frecuente en la infancia y la adolescencia, corresponde al 20% de todos los tumores óseos y al 5% de los cánceres pediátricos.
Vega Villa, Óscar Andrés
core  

Analysis of RUNX2 expression in SKOV3 cells.

, 2013
A. Semi-quantitative duplex RT-PCR analysis of RUNX2 mRNA expression levels in the shRNA-RUNX2 clones 3 and 6, compared to the mock-transfected control clone. Displayed are images of representative results following sqRT-PCR analysis.
Stephane Gobeil (108928), Marie-Claude Renaud (467072), Dimcho Bachvarov (30717), Zhi-Qiang Wang (244034), Mamadou Keita (467069), Magdalena Bachvarova (74369), Alexandra Sebastianelli (467073), Xuan Bich Trinh (347448), Chantale Morin (467070), Marie Plante (21802), Jean Gregoire (467071)   +10 more
core   +1 more source

Pin1-mediated Runx2 modification is critical for skeletal development

, 2013
Runx2 is the master transcription factor for bone formation. Haploinsufficiency of RUNX2 is the genetic cause of cleidocranial dysplasia (CCD) that is characterized by hypoplastic clavicles and open fontanels.
Islam, Rabia, Woo, Kyung-Mi, Baek, Jeong-Hwa, Stein, Janet L., Bae, Suk-Chul, Lian, Jane B., Yoon, Won-Joon, van Wijnen, Andre, Komori, Toshihisa, Cho, Young-Dan, Uchida, Takafumi, Choi, Je-Yong, Stein, Gary S., Ryoo, Hyun-Mo   +13 more
core   +2 more sources

DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes

Scientific Reports, 2017
The Runt-related transcription factor 2 (RUNX2) is critical for bone formation as well as chondrocyte maturation. Matrix metalloproteinase (MMP)-13 is a major contributor to cartilage degradation in osteoarthritis (OA).
Atsushi Takahashi, María C. de Andrés, Ko Hashimoto, Eiji Itoi, Miguel Otero, Mary B. Goldring, Richard O. C. Oreffo   +6 more
doaj   +1 more source

Primary extraskeletal osteosarcoma of the omentum in a young dog

Brazilian Journal of Veterinary Pathology
Extraskeletal osteosarcoma (EOSA) is a rare and aggressive mesenchymal neoplasm in dogs, primarily affecting older animals, with the spleen being the most common site of involvement.
João Pedro Sanches de Ávila, André Gustavo Alves Holanda, Caroline Cristine Ferreira Mazula, João Antônio Ulhôa Oliveira, Fernanda Gosuen Gonçalves Dias, Pâmela Rodrigues Reina Moreira, Denner Santos dos Anjos   +6 more
doaj   +1 more source

Specific Residues of RUNX2 Are Obligatory for Formation of BMP2-Induced RUNX2-SMAD Complex to Promote Osteoblast Differentiation

, 2008
BMP2 signaling and RUNX2 regulatory pathways converge for transcriptional control of bone formation in vivo. SMAD proteins are recruited to RUNX2 regulatory complexes via an overlapping nuclear matrix targeting signal/Smad interacting domain sequence ...
Pratap, Jitesh, Janet L. Stein, Gary S. Stein, Soraya Gutierrez, Stein, Janet L., Javed, Amjad, Faiza Afzal, Van Wijnen, Andre J., Andre J. van Wijnen, Jong-Sup Bae, Jitesh Pratap, Lian, Jane B., Gutierrez, Soraya E., Amjad Javed, Kaleem Zaidi, Bae, Jong-Sup, Jane B. Lian, Afzal, Faiza, Zaidi, Kaleem, Stein, Gary S.   +19 more
core   +1 more source