Results 71 to 80 of about 69,808 (343)

BET protein inhibitor JQ1 downregulates chromatin accessibility and suppresses metastasis of gastric cancer via inactivating RUNX2/NID1 signaling

Oncogenesis, 2020
Chromatin accessibility is critical for tumor development, whose mechanisms remain unclear. As a crucial regulator for chromatin remodeling, BRD4 promotes tumor progression by regulating multiple genes.
Si-Qi Zhou, Shu Zhang, Lei Wang, Shuling Huang, Yue Yuan, Jie Yang, Hui Wang, Xihan Li, Pin Wang, Lin Zhou, Jun Yang, Yue-Mei Xu, Huan Gao, Yi-Xuan Zhang, Y. Lv, X. Zou   +15 more
semanticscholar   +1 more source

A Zic2/Runx2/NOLC1 signaling axis mediates tumor growth and metastasis in clear cell renal cell carcinoma

Cell Death and Disease, 2021
Clear cell renal cell carcinoma (ccRCC) is one of the most common malignancies with rapid growth and high metastasis, but lacks effective therapeutic targets. Here, using public sequencing data analyses, quantitative real-time PCR assay, western blotting,
Chen-Yan Wu, Lei Li, Shi‐Lu Chen, Xia Yang, C. Z. Zhang, Yun Cao   +5 more
semanticscholar   +1 more source

Runx2/Sp7 double transgenic mice.

, 2012
(A) X-ray analysis of lower limb bones from a wild-type mouse (wt), Runx2 transgenic mouse (Runx2), Sp7 transgenic mouse (Sp7), and Runx2/Sp7 double transgenic mouse (Runx2/Sp7) at 6 weeks of age.
Hiroshi Kawaguchi (33997), Kouhei Nakamura (180123), Takeshi Moriishi (154743), Kenji Takada (180138), Zenjiro Maruyama (180098), Kei Yamana (180117), Hisato Komori (154755), Keishi Kawasaki (180103), Masako Mori (180113), Satoru Toyosawa (180128), Toshihisa Komori (154757), Wenguang Liu (147612), Toshihiro Miyazaki (154749), Carolina A. Yoshida (180093), Tatsuya Furuichi (180107), Ryo Fukuyama (154745)   +15 more
core   +1 more source

Antagonistic Functions of USAG-1 and RUNX2 during Tooth Development [PDF]

, 2016
Supernumerary teeth and tooth agenesis are common morphological anomalies in humans. We previously obtained evidence that supernumerary maxillary incisors form as a result of the successive development of the rudimentary maxillary incisor tooth germ in ...
Mary MacDougall, Kazuyuki Saito (506650), Sugai, Manabu, Motoko Yanagita, Yanagita, Motoko, Manabu Sugai, Yumiko Togo, Boyen Huang (342326), Bessho, Kazuhisa, Manabu Sugai (342332), Yumiko Togo (562202), Honoka Kiso (342330), Toshihisa Komori, Komori, Toshihisa, Saito, Kazuyuki, Togo, Yumiko, Takahashi, Katsu, MacDougall, Mary, Kazuhisa Bessho, Kazuhisa Bessho (65293), Huang, Boyen, Hidemitsu Harada, Hiroko Tsukamoto (562203), Harada, Hidemitsu, Kiso, Honoka, Tsukamoto, Hiroko, Honoka Kiso, Akira Shimizu, Hiroko Tsukamoto, Katsu Takahashi (342327), Akira Shimizu (342338), Kazuyuki Saito, Boyen Huang, Motoko Yanagita (134965), Mary MacDougall (2182746), Toshihisa Komori (154757), Shimizu, Akira, Hidemitsu Harada (2940285), Katsu Takahashi   +38 more
core   +2 more sources

RUNX2-modifying enzymes: therapeutic targets for bone diseases

Experimental and Molecular Medicine, 2020
RUNX2 is a master transcription factor of osteoblast differentiation. RUNX2 expression in the bone and osteogenic front of a suture is crucial for cranial suture closure and membranous bone morphogenesis.
Woo-Jin Kim, Hye-Lim Shin, Bong-Soo Kim, Hyun-Jung Kim, H. Ryoo   +4 more
semanticscholar   +1 more source

The phenotypes of Usag-1^+/+/Runx2^+/+, Usag-1^+/+/Runx2^-/-, Usag-1^-/-/Runx2^+/+ and Usag-1^-/-/Runx2^-/- mice at E15 and P0.

, 2016
The phenotypes of Usag-1+/+/Runx2+/+, Usag-1+/+/Runx2-/-, Usag-1-/-/Runx2+/+ and Usag-1-/-/Runx2-/- mice at E15 and P0.
Kazuyuki Saito (506650), Hiroko Tsukamoto (562203), Boyen Huang (342326), Katsu Takahashi (342327), Akira Shimizu (342338), Manabu Sugai (342332), Yumiko Togo (562202), Motoko Yanagita (134965), Mary MacDougall (2182746), Toshihisa Komori (154757), Honoka Kiso (342330), Hidemitsu Harada (2940285), Kazuhisa Bessho (65293)   +12 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Talla baja asociada a dientes supernumerarios y anomalías esqueléticas como clave diagnóstica de displasia cleidocraneal en pediatría. Caso clínico.

Revista GICOS
La displasia cleidocraneal (OMIM #119600) es una osteocondrodisplasia de herencia autosómica dominante debida a una mutación en heterocigosis en el gen RUNX2. Su prevalencia es 1 en 1.000.000 individuos.
Nolis Camacho-Camargo, Francisco Cammarata-Scalisi, Gloria Fátima Silva de Arenas, Carmine Lobo-Vielma, Yoselyn Martorelli-Suarez   +4 more
doaj   +1 more source

Identification of the hub genes RUNX2 and FN1 in gastric cancer

Open Medicine, 2020
This study identified key genes in gastric cancer (GC) based on the mRNA microarray GSE19826 from the Gene Expression Omnibus (GEO) database and preliminarily explored the relationships among the key genes.
Han Chao, Jin Lei, Ma Xuemei, Hao Qin, Lin Huajun, Zhang Zhongtao   +5 more
doaj   +1 more source

Inducible regulation of Runx2-stimulated osteogenesis [PDF]

Gene Therapy, 2006
Ex vivo gene therapy is a promising approach to orthopedic regenerative medicine. These strategies typically focus on the constitutive overexpression of osteogenic factors to induce osteoblastic differentiation and matrix mineralization. However, the unregulated production of osteoinductive molecules has also resulted in abnormal bone formation and ...
C A, Gersbach, J M, Le Doux, R E, Guldberg, A J, García   +3 more
openaire   +2 more sources