Results 81 to 90 of about 52,415 (197)

Long non-coding RNAs in bone formation: Key regulators and therapeutic prospects

Open Life Sciences
Recent scientific investigations have revealed the intricate mechanisms underlying bone formation, emphasizing the essential role of long non-coding RNAs (lncRNAs) as critical regulators.
Jiang Chun, Wang Peng, Tan ZhenWei, Zhang Yin   +3 more
doaj   +1 more source

Expressão das proteínas da matriz na discondroplasia da tíbia [PDF]

, 2010
Doutoramento em BiologiaA discondroplasia da tíbia (TD) em aves consiste numa anomalia do esqueleto onde existe uma falha nos processos normais da ossificação endocondral.
Velada, Isabel de Jesus Pereira Godinho
core  

Genetic and Functional Characterization of RUNX2

, 2007
RUNX2 belongs to the RUNT domain family of transcription factors of which three have been identified in humans (RUNX1, RUNX2 and RUNX3). RUNX proteins are vital for metazoan development and participate in the regulation of cellular differentiation and ...
Stephens, Alexandre
core   +1 more source

RUNX2 analysis of Danish cleidocranial dysplasia families

, 2011
Cleidocranial dysplasia (CCD) is an autosomal dominant inherited disease caused by mutations in the Runt gene RUNX2. Screening of 19 Danish CCD families revealed 16 pathogenic mutations (84%) representing 8 missense mutations, 2 nonsense mutations, 4 ...
Silahtaroglu, A, Kreiborg, S, Eiberg, H, Riis, A K, Hove, H, Lauridsen, E, Hansen, L   +6 more
core   +1 more source

Epigenome editing revealed the role of DNA methylation of T-DMR/CpG island shore on Runx2 transcription

Biochemistry and Biophysics Reports
RUNX2 is a transcription factor crucial for bone formation. Mutant mice with varying levels of Runx2 expression display dosage-dependent skeletal abnormalities, underscoring the importance of Runx2 dosage control in skeletal formation.
Yutaro Kawa, Miyuki Shindo, Jun Ohgane, Masafumi Inui   +3 more
doaj   +1 more source

HES1 cooperates with pRb to activate RUNX2-dependent transcription

, 2018
The retinoblastoma protein, pRb, can activate the transcription factor RUNX2, an essential regulator of osteogenic differentiation, but the mechanism of this activation is unknown.
이종서
core   +1 more source

RUNX2 isoform II protects cancer cells from ferroptosis and apoptosis by promoting PRDX2 expression in oral squamous cell carcinoma

eLife
Ferroptosis is a distinct iron-dependent programmed cell death and plays important roles in tumor suppression. However, the regulatory mechanisms of ferroptosis need further exploration. RUNT-related transcription factor 2 (RUNX2), a transcription factor,
Junjun Huang, Rong Jia, Jihua Guo
doaj   +1 more source

The prolyl hydroxylase inhibitor dimethyloxalylglycine enhances dentin sialophoshoprotein expression through VEGF-induced Runx2 stabilization.

PLoS ONE, 2014
Prolyl hydroxylase (PHD) inhibitors are suggested as therapeutic agents for tissue regeneration based on their ability to induce pro-angiogenic responses.
Saeed Ur Rahman, Min-Sun Lee, Jeong-Hwa Baek, Hyun-Mo Ryoo, Kyung Mi Woo   +4 more
doaj   +1 more source

Expression of Runx2 in calcified ligament.

, 2013
A, Runx2 expression (arrowheads) in the posterior longitudinal ligament (arrows). In situ hybridization of Runx2 in wild-type (WT) mouse vertebrae at birth (left). LacZ staining in WT mouse vertebrae at birth (middle). Immunohistochemistry of Runx2 in WT
Hiroyuki Inose (310743), Yoshinori Asou (310747), Makiko Iwasaki (310737), Shingo Sato (185673), Jinying Piao (310739), Hiroki Ochi (310745), Shu Takeda (310753), Ayako Kimura (310741), Kenichi Shinomiya (310750), Atsushi Okawa (310752)   +9 more
core   +1 more source

Runx2 and dental development

, 2006
The Runx2 gene is a master transcription factor of bone and plays a role in all stages of bone formation. It is essential for the initial commitment of mesenchymal cells to the osteoblastic lineage and also controls the proliferation, differentiation ...
Camilleri, S, McDonald, F
core   +3 more sources