Results 81 to 90 of about 69,808 (343)

Runx2 gene construct and splicing patterns.

, 2014
Runx2 transcription is induced by distal and proximal promoters (P1 and P2, respectively). Although the first exon of Runx2-II contains a 197-bp mini-intron, the two parts of the exon are often shown as a single exon (exon 1), as we have done here (gray ...
Tomoki Nakashima (632614), Hiroshi Takayanagi (261902), Shintaro Sato (268347), Nobuaki Yoshida (111039), Hiroshi Kiyono (69959), Hideaki Okura (632611), Satoshi Kaneto (632613), Sari Kishikawa (632612)   +7 more
core   +1 more source

Single‐Cell Resolution Mapping of Osteoarthritis‐Associated Chondrocyte Dynamics Using a High‐Density CMOS MEA Platform

Advanced Healthcare Materials, EarlyView.
Single‐cell and spatially resolved impedance mapping using a high‐density CMOS‐MEA platform enables non‐invasive monitoring of osteoarthritis‐associated chondrocyte dynamics. Continuous label‐free measurements reveal heterogeneous remodeling behaviors, including proliferation, migration, and phenotypic transitions, establishing a powerful approach for ...
Neha Deshpande, Pauline Coquart, Bram Theuns, Susanne Cremery, Jaime Rodolfo V. Garcia III, Julien Verplanken, Dennis Lambrechts, Dries Braeken, Liesbet Lagae, Johanna Bolander   +9 more
wiley   +1 more source

RUNX2 promotes malignant progression in gastric cancer by regulating COL1A1

Cancer Biomarkers, 2021
BACKGROUND: Runt-related transcription factor 2 (RUNX2) is an important gene that has been implicated in the progression of human cancer. Aberrant expression of RUNX2 predicts gastric cancer (GC) metastasis.
Yanlei Li, Ran Sun, Xiu-Lan Zhao, Bao-Cun Sun   +3 more
semanticscholar   +1 more source

Hybrid Biofabrication of a Hierarchically Organized Periosteum‐Inspired In Vitro Platform

Advanced Healthcare Materials, EarlyView.
A hybrid biofabrication strategy integrates melt electrowriting with extrusion‐based 3D bioprinting to create a hierarchically organized periosteum‐inspired in vitro platform. Spatially defined osteogenic, fibrous, and endothelial cell‐containing compartments support long‐term culture, osteogenic maturation, and CD31+ endothelial cell organization ...
Yakui Liu, Xinggui Tian, Anne Bernhardt, Anja Lode, Max von Witzleben, Ege Kirbas, Stefan Zwingenberger, Michael Gelinsky   +7 more
wiley   +1 more source

Role of Runx2 in Calcific Aortic Valve Disease in Mouse Models

Frontiers in Cardiovascular Medicine, 2021
Background: Calcific aortic valve disease is common in the aging population and is characterized by the histological changes of the aortic valves including extracellular matrix remodeling, osteochondrogenic differentiation, and calcification.
S. Dharmarajan, Mei Y. Speer, Katelyn Pierce, J. Lally, Elizabeth M. Leaf, Mu-En Lin, M. Scatena, C. Giachelli   +7 more
semanticscholar   +1 more source

Smad6 Interacts with Runx2 and Mediates Smad Ubiquitin Regulatory Factor 1-induced Runx2 Degradation [PDF]

Journal of Biological Chemistry, 2006
Runx2 is a bone-specific transcription factor that plays a critical role in bone development, postnatal bone formation, and chondrocyte maturation. The protein levels of Runx2 are regulated by the ubiquitin-proteasome pathway. In previous studies we discovered that E3 ubiquitin ligase Smad ubiquitin regulatory factor 1 (Smurf1) induces Runx2 ...
Run, Shen, Mo, Chen, Yong-Jun, Wang, Hiroyuki, Kaneki, Lianping, Xing, Regis J, O'keefe, Di, Chen   +6 more
openaire   +2 more sources

Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter [PDF]

, 2005
Two major isoforms of the Runx2 gene are expressed by alternative promoter usage: Runx2 type I (Runx2-I) is derived from the proximal promoter (P2), and Runx2 type II (Runx2-II) is produced by the distal promoter (P1).
Hwang, Yoo-Seok, Cho, Je-Yoel, Kim, Jee-In, Kim, Byung-Gyu, Bae, Suk-Chul, Kim, Youn-Jeong, Yoon, Won-Joon, Chi, Xin-Zi, Lee, Mi-Hye, Wozney, John M., Choi, Je-Yong, Choi, Kang-Young, Ryoo, Hyun-Mo   +12 more
core   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

The neo transgene perturbed Runx2 expression.

, 2014
(A) Expression of total Runx2, Runx2-I, and Runx2-II in Runx2-I-mutated mice. Expression was analyzed by quantitative real-time PCR using RNA prepared from E18.5 calvarial cells of wild-type (+/+), Runx2-Ineo/+ (neo/+) and Runx2-Ineo/neo (neo/neo) mice ...
Tomoki Nakashima (632614), Hiroshi Takayanagi (261902), Shintaro Sato (268347), Nobuaki Yoshida (111039), Hiroshi Kiyono (69959), Hideaki Okura (632611), Satoshi Kaneto (632613), Sari Kishikawa (632612)   +7 more
core   +1 more source

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source