Results 61 to 70 of about 52,415 (197)

C/EBPβ binds the P1 promoter of the Runx2 gene and up‐regulates Runx2 transcription in osteoblastic cells [PDF]

Journal of Cellular Physiology, 2011
AbstractThe Runx2 factor is an essential component of the regulatory mechanisms that control transcription during skeletogenesis. Runx2/p57 expression in osteoblastic cells is controlled by the P1 promoter, which is recognized by key regulators of osteoblast differentiation including homeodomain factors and Wnt‐ and BMP‐signaling mediators.
Henriquez, B., Hepp, M., Merino, P., Sepúlveda, H., Van Wijnen, A.J., Lian, J.B., Stein, J.L., Stein, G.S., Montecino, M.   +8 more
openaire   +7 more sources

SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2. [PDF]

PLoS ONE, 2017
Activation of SIRT1 has previously been shown to protect mice against osteoporosis through yet ill-defined mechanisms. In this study, we outline a role for SIRT1 as a positive regulator of the master osteoblast transcription factor, RUNX2.
Kayvan Zainabadi, Cassie J Liu, Leonard Guarente   +2 more
doaj   +1 more source

Runx2 haploinsufficiency ameliorates the development of ossification of the posterior longitudinal ligament. [PDF]

PLoS ONE, 2012
Ossification of the Posterior Longitudinal Ligament (OPLL) is a disease that is characterized by the ectopic calcification of the ligament; however, the pathogenesis of OPLL remains to be investigated.
Makiko Iwasaki, Jinying Piao, Ayako Kimura, Shingo Sato, Hiroyuki Inose, Hiroki Ochi, Yoshinori Asou, Kenichi Shinomiya, Atsushi Okawa, Shu Takeda   +9 more
doaj   +1 more source

Antagonistic Functions of USAG-1 and RUNX2 during Tooth Development. [PDF]

PLoS ONE, 2016
Supernumerary teeth and tooth agenesis are common morphological anomalies in humans. We previously obtained evidence that supernumerary maxillary incisors form as a result of the successive development of the rudimentary maxillary incisor tooth germ in ...
Yumiko Togo, Katsu Takahashi, Kazuyuki Saito, Honoka Kiso, Hiroko Tsukamoto, Boyen Huang, Motoko Yanagita, Manabu Sugai, Hidemitsu Harada, Toshihisa Komori, Akira Shimizu, Mary MacDougall, Kazuhisa Bessho   +12 more
doaj   +1 more source

Runx2/Sp7 double transgenic mice.

, 2012
(A) X-ray analysis of lower limb bones from a wild-type mouse (wt), Runx2 transgenic mouse (Runx2), Sp7 transgenic mouse (Sp7), and Runx2/Sp7 double transgenic mouse (Runx2/Sp7) at 6 weeks of age.
Hiroshi Kawaguchi (33997), Kouhei Nakamura (180123), Takeshi Moriishi (154743), Kenji Takada (180138), Zenjiro Maruyama (180098), Kei Yamana (180117), Hisato Komori (154755), Keishi Kawasaki (180103), Masako Mori (180113), Satoru Toyosawa (180128), Toshihisa Komori (154757), Wenguang Liu (147612), Toshihiro Miyazaki (154749), Carolina A. Yoshida (180093), Tatsuya Furuichi (180107), Ryo Fukuyama (154745)   +15 more
core   +1 more source

The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts

, 2009
Heparan sulfate proteoglycans cooperate with basic fibroblast growth factor (bFGF/FGF2) signaling to control osteoblast growth and differentiation, as well as metabolic functions of osteoblasts.
Stein, JL, Haupt, Larisa, Cool, SM, Ling, L, Lian, JB, Van Wijnen, AJ, Stein, Janet L., van Wijnen, Andre J., S. Nathan, Saminathan, Nathan, SS, Mun, Foong Kin, Foong, KM, Stein, GS, Haupt, LM, Ling, Ling, S. Stein, Gary, Cool, Simon M., Nathan, Saminathan S., B. Lian, Jane, M.Teplyuk, Nadiya, J. van Wijnen, Andre, Teplyuk, NM, Lian, Jane B., L. Stein, Janet, M. Cool, Simon, Dombrowski, Christian, Dombrowski, C, Stein, Gary S., Teplyuk, Nadiya M., Haupt, Larisa M.   +29 more
core   +1 more source

HDACs control RUNX2 expression in cancer cells through redundant and cell context-dependent mechanisms

Journal of Experimental & Clinical Cancer Research, 2019
Background RUNX2 is a Runt-related transcription factor required during embryogenesis for skeletal development and morphogenesis of other organs including thyroid and breast gland.
Gloria Manzotti, Federica Torricelli, Benedetta Donati, Valentina Sancisi, Mila Gugnoni, Alessia Ciarrocchi   +5 more
doaj   +1 more source

Bone morphogenetic protein-2 stimulates RUNX2 acetylation

, 2006
Runx2/Cbfa1/Pebp2aA is a global regulator of osteogenesis and is crucial for regulating the expression of bone-specific genes. Runx2 is a major target of the bone morphogenetic protein (BMP) pathway.
Norikazu Nishino, Je-Yong Choi, Jin, Yun-Hye, Eun-Joo Jeon, Byung-Chul Oh, Nishino, Norikazu, Lee, Kyeong-Sook, Hyun-Mo Ryoo, Minoru Yoshida, Mi-Hye Lee, Choi, Je-Yong, Hyun-Nam Kim, Choi, Nam-Sook, Kyeong-Sook Lee, Yun-Hye Jin, Jeon, Eun-Joo, Yong Hee Lee, Lee, Kwang-Youl, Kim, Hyun-Nam, Lee, Yong Hee, Yoshida, Minoru, Bae, Suk-Chul, Nam-Sook Choi, Suk-Chul Bae, Kwang-Youl Lee, Lee, Mi-Hye, Oh, Byung-Chul, Ryoo, Hyun-Mo   +27 more
core   +1 more source

Phosphorylated MAPK14 Promotes the Proliferation and Migration of Bladder Cancer Cells by Maintaining RUNX2 Protein Abundance

Cancer Management and Research, 2020
Junlong Liu,1 Xiuyue Yu,1 Bitian Liu,2 Hongyuan Yu,1 Zhenhua Li1 1Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, People’s Republic of China; 2Department of Urology, Shengjing Hospital of China ...
Liu J, Yu X, Liu B, Yu H, Li Z
doaj  

Runx2 and Vascular Calcification [PDF]

, 2016
Thesis (Ph.D.)--University of Washington, 2016-06Complications arising from vascular calcification, the inappropriate deposition of calcium phosphate crystals in the vasculature, have become more evident in recent years as human longevity has increased ...
Chen, Theodore
core