RUNX2 Reverses p53-Induced Chemotherapy Resistance in Gastric Cancer
Pharmacogenomics and Personalized Medicine, 2023 Yuan Huang,1 Lu Liang,2 Yong-Xiang Zhao,3 Bi-Hui Yao,2 Rui-Min Zhang,3 Lei Song,2 Zhong-Tao Zhang1 1Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People’s Republic of China; 2Department of ...
Huang Y +6 more
doaj
RUNX2 promotes fibrosis via alveolar-to-pathological fibroblast transition
NatureA hallmark of pulmonary fibrosis is the aberrant activation of lung fibroblasts into pathological fibroblasts that produce excessive extracellular matrix1, 2–3.
Yin-Shan Fang +17 more
semanticscholar +1 more source
Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis [PDF]
, 2023 Haploinsufficiency of Runt-related transcription factor-2 (RUNX2) is responsible for cleidocranial dysplasia (CCD), a rare hereditary disease with a range of defects, including delayed closure of the cranial sutures and short stature.
Chen, Zhi +6 more
core +1 more source
Biomolecular Concepts, 2020 Human periodontal ligament stem cells (HPDLSCs) are a unique population of mesenchymal stem cells (MSCs). Recently, the positive effects of photobiomodulation on the regulation of MSCs proliferation and osteogenic differentiation have gained significant ...
Abdelgawad Latifa Mohamed +3 more
doaj +1 more source
Runx2-I was expressed in Runx2-ITGA/TGA mice as N-terminal truncated Runx2.
, 2014 (A) Anti-Runx2 mAb (clone: 8G5) could recognize Runx2-II, Runx2-I, and their truncated versions. HEK293 cells were transiently transfected with the indicated expression vectors (see Materials and Methods).
Tomoki Nakashima (632614) +7 more
core +1 more source
DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs. [PDF]
Adv Sci (Weinh)p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Lv Y +15 more
europepmc +2 more sources
Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2
Communications Biology, 2021 Runx2 is an essential transcription factor for bone formation. Although osteocalcin, osteopontin, and bone sialoprotein are well-known Runx2-regulated bone-specific genes, the skeletal phenotypes of knockout (KO) mice for these genes are marginal ...
Y. Takahata +14 more
semanticscholar +1 more source
Role and regulation of RUNX2 in osteogenesis
European Cells and Materials, 2014 Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked.
Bruderer M +3 more
openaire +4 more sources
Runx2 Integrates Estrogen Activity in Osteoblasts [PDF]
Journal of Biological Chemistry, 2003 Steroids significantly effect skeletal integrity. For example, bone mass decreases with glucocorticoid excess or with estrogen depletion after menopause. Glucocorticoid suppresses gene expression by an essential skeletal tissue transcription factor, Runx2, in rat osteoblasts.
Thomas L, McCarthy +3 more
openaire +2 more sources
The transcription factor Runx2 is under circadian control in the suprachiasmatic nucleus and functions in the control of rhythmic behavior. [PDF]
PLoS ONE, 2013 Runx2, a member of the family of runt-related transcription factors, is rhythmically expressed in bone and may be involved in circadian rhythms in bone homeostasis and osteogenesis. Runx2 is also expressed in the brain, but its function is unknown.
Meghan E Reale +5 more
doaj +1 more source