Results 91 to 100 of about 66,303 (295)

SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2. [PDF]

PLoS ONE, 2017
Activation of SIRT1 has previously been shown to protect mice against osteoporosis through yet ill-defined mechanisms. In this study, we outline a role for SIRT1 as a positive regulator of the master osteoblast transcription factor, RUNX2.
Kayvan Zainabadi, Cassie J Liu, Leonard Guarente   +2 more
doaj   +1 more source

Graphene-based nanomaterials for tissue engineering in the dental field [PDF]

, 2018
The world of dentistry is approaching graphene-based nanomaterials as substitutes for tissue engineering. Apart from its exceptional mechanical strength, electrical conductivity and thermal stability, graphene and its derivatives can be functionalized ...
Antoniac, I, Bellin, G, Bressan, E, Ferroni, L, Gardin, C, Guazzo, R, Ludovichetti, FRANCESCO SAVERIO, Piattelli, A, Sbricoli, L, Zavan, B   +9 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Antagonistic Functions of USAG-1 and RUNX2 during Tooth Development. [PDF]

PLoS ONE, 2016
Supernumerary teeth and tooth agenesis are common morphological anomalies in humans. We previously obtained evidence that supernumerary maxillary incisors form as a result of the successive development of the rudimentary maxillary incisor tooth germ in ...
Yumiko Togo, Katsu Takahashi, Kazuyuki Saito, Honoka Kiso, Hiroko Tsukamoto, Boyen Huang, Motoko Yanagita, Manabu Sugai, Hidemitsu Harada, Toshihisa Komori, Akira Shimizu, Mary MacDougall, Kazuhisa Bessho   +12 more
doaj   +1 more source

Runx2 Protein Expression Utilizes the Runx2 P1 Promoter to Establish Osteoprogenitor Cell Number for Normal Bone Formation [PDF]

Journal of Biological Chemistry, 2011
The Runt-related transcription factor, Runx2, is essential for osteogenesis and is controlled by both distal (P1) and proximal (P2) promoters. To understand Runx2 function requires determination of the spatiotemporal activity of P1 and P2 to Runx2 protein production. We generated a mouse model in which the P1-derived transcript was replaced with a lacZ
Liu, Julie C., Lengner, Christopher Joachim, Gaur, Tripti, Lou, Yang, Hussain, Sadiq, Jones, Marci D., Borodic, Brent, Colby, Jennifer L., Steinman, Heather Anne, Van Wijnen, Andre J., Stein, Janet L., Jones, Stephen N., Stein, Gary S., Lian, Jane B.   +13 more
openaire   +3 more sources

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Primary extraskeletal osteosarcoma of the omentum in a young dog

Brazilian Journal of Veterinary Pathology
Extraskeletal osteosarcoma (EOSA) is a rare and aggressive mesenchymal neoplasm in dogs, primarily affecting older animals, with the spleen being the most common site of involvement.
João Pedro Sanches de Ávila, André Gustavo Alves Holanda, Caroline Cristine Ferreira Mazula, João Antônio Ulhôa Oliveira, Fernanda Gosuen Gonçalves Dias, Pâmela Rodrigues Reina Moreira, Denner Santos dos Anjos   +6 more
doaj   +1 more source

Adipose-derived stem cells: a review of osteogenesis differentiation [PDF]

, 2016
Second part of manuscript based on osteogenesis differentiation of stem cells. Bones are highly regenerative organs but there are still many problems with therapy of large bone defects.
Mazurek, Urszula, Sikora, Bartosz, Skubis, Aleksandra, Wojdas, Emilia, Zmarzły, Nikola   +4 more
core   +2 more sources

Twist Genes Regulate Runx2 and Bone Formation [PDF]

Developmental Cell, 2004
Runx2, a master regulator of osteoblast differentiation, is expressed several days before osteoblast genes in bone anlage. In this issue of Developmental Cell, show that Twist-1 and Twist-2 suppress the activity of Runx2 and thereby regulate bone formation.
openaire   +2 more sources

Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 gene [PDF]

Journal of Cellular Physiology, 2012
AbstractEpigenetic mechanisms mediating expression of the Runt‐related transcription factor Runx2 are critical for controlling its osteogenic activity during skeletal development. Here, we characterized bona fide regulatory elements within 120 kbp of the endogenous bone‐related Runx2 promoter (P1) in osteoblasts by genomic DNase I footprinting and ...
Hovhannisyan, Hayk, Zhang, Ying, Hassan, Mohammad Q., Wu, Hai, Glackin, Carlotta, Lian, Jane B., Stein, Janet L., Montecino, Martin A., Stein, Gary S., Van Wijnen, Andre J.   +9 more
openaire   +3 more sources