Results 91 to 100 of about 69,808 (343)
A CTGF‐RUNX2‐RANKL Axis in Breast and Prostate Cancer Cells Promotes Tumor Progression in Bone
Journal of Bone and Mineral Research, 2020 Metastasis to bone is a frequent occurrence in patients with breast and prostate cancers and inevitably threatens the patient's quality of life and survival.
Bongjun Kim +7 more
semanticscholar +1 more source
HES1 cooperates with pRb to activate RUNX2-dependent transcription
, 2018 The retinoblastoma protein, pRb, can activate the transcription factor RUNX2, an essential regulator of osteogenic differentiation, but the mechanism of this activation is unknown.
이종서
core +1 more source
Advanced Science, EarlyView.A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao +7 more
wiley +1 more source
Runx2 Regulates Mouse Tooth Root Development Via Activation of WNT Inhibitor NOTUM
Journal of Bone and Mineral Research, 2020 Progenitor cells are crucial in controlling organ morphogenesis. Tooth development is a well‐established model for investigating the molecular and cellular mechanisms that regulate organogenesis.
Quan Wen +8 more
semanticscholar +1 more source
Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 gene [PDF]
Journal of Cellular Physiology, 2012 AbstractEpigenetic mechanisms mediating expression of the Runt‐related transcription factor Runx2 are critical for controlling its osteogenic activity during skeletal development. Here, we characterized bona fide regulatory elements within 120 kbp of the endogenous bone‐related Runx2 promoter (P1) in osteoblasts by genomic DNase I footprinting and ...
Hovhannisyan, Hayk +9 more
openaire +3 more sources
The Ihh-Gli pathway positively induces Runx2 and Runx3.
, 2013 (A) Compared to the pGL3-basic, treatment with 10 ng of the Gli1 expression vector leads to a significant increase of wild-type Runx2 containing Gli-binding site (pGL3-Runx2 WT, 500 ng), but the luciferase activity of Runx2 containing mutated Gli-binding
Sung-Won Cho (142556) +5 more
core +1 more source
Advanced Science, EarlyView.ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao +6 more
wiley +1 more source
Cancer Management and Research, 2020 Junlong Liu,1 Xiuyue Yu,1 Bitian Liu,2 Hongyuan Yu,1 Zhenhua Li1 1Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, People’s Republic of China; 2Department of Urology, Shengjing Hospital of China ...
Liu J, Yu X, Liu B, Yu H, Li Z
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East Java green tea methanolic extract can enhance RUNX2 and Osterix expression during orthodontic tooth movement in vivo [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2020 Context: Alveolar bone remodeling is important to achieve an optimal Orthodontic Tooth Movement (OTM). Runt-related transcription factor 2 (RUNX2) and Osterix (OSX) expression are important for bone remodeling.
Putri I. Sitasari +5 more
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Advanced Science, EarlyView.Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su +14 more
wiley +1 more source