Results 111 to 120 of about 69,808 (343)

Runx2 haploinsufficiency ameliorates the development of ossification of the posterior longitudinal ligament. [PDF]

PLoS ONE, 2012
Ossification of the Posterior Longitudinal Ligament (OPLL) is a disease that is characterized by the ectopic calcification of the ligament; however, the pathogenesis of OPLL remains to be investigated.
Makiko Iwasaki, Jinying Piao, Ayako Kimura, Shingo Sato, Hiroyuki Inose, Hiroki Ochi, Yoshinori Asou, Kenichi Shinomiya, Atsushi Okawa, Shu Takeda   +9 more
doaj   +1 more source

Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2

Nature Communications, 2019
Vascular calcification is highly prevalent in end-stage renal diseases and is predictive of cardiovascular events and mortality. Poly(ADP-ribose) polymerase 1 (PARP1) inhibition or deletion is vasoprotective in several disease models.
Cheng Wang, Wen-Jing Xu, J. An, Ming-Lu Liang, Yi-Qing Li, Feng-Xiao Zhang, Q. Tong, Kai Huang   +7 more
semanticscholar   +1 more source

Regulatory mechanisms of central nervous system by Runx2 [PDF]

我々は、骨芽細胞特異的表現型を特徴付けるRunt-related transcription factor 2(Runx2)分子が、中枢神経系にも機能的に発現する事実を報告した。本研究では、個体レベルでのRunx2の脳機能解析を実施する目的で、Cre/loxPシステムを利用したRunx2 conditional欠損マウスの作製に取り組み、Runx2遺伝子のexon 4をloxP配列にて挟んだRunx2^flox/+のマウス作製に成功した。We have previously shown the ...
70020, 宝田, 剛志, 30377428
core   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation

, 2015
The synthesis of type I collagen, the main component of bone matrix, precedes the expression of Runx2, the earliest determinant of osteoblast differentiation. We hypothesized that the energetic needs of osteoblasts might explain this apparent paradox. We
Zong H., Shimazu J., Lezaki T., Hinoi E., Kajimura D., Pessin J. E., Karsenty G., Wei J., Takarada T., Makinistoglu M. P., Maurizi A.   +10 more
core   +2 more sources

Primary extraskeletal osteosarcoma of the omentum in a young dog

Brazilian Journal of Veterinary Pathology
Extraskeletal osteosarcoma (EOSA) is a rare and aggressive mesenchymal neoplasm in dogs, primarily affecting older animals, with the spleen being the most common site of involvement.
João Pedro Sanches de Ávila, André Gustavo Alves Holanda, Caroline Cristine Ferreira Mazula, João Antônio Ulhôa Oliveira, Fernanda Gosuen Gonçalves Dias, Pâmela Rodrigues Reina Moreira, Denner Santos dos Anjos   +6 more
doaj   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Pin1-mediated Runx2 modification is critical for skeletal development

, 2013
Runx2 is the master transcription factor for bone formation. Haploinsufficiency of RUNX2 is the genetic cause of cleidocranial dysplasia (CCD) that is characterized by hypoplastic clavicles and open fontanels.
Islam, Rabia, Woo, Kyung-Mi, Baek, Jeong-Hwa, Stein, Janet L., Bae, Suk-Chul, Lian, Jane B., Yoon, Won-Joon, van Wijnen, Andre, Komori, Toshihisa, Cho, Young-Dan, Uchida, Takafumi, Choi, Je-Yong, Stein, Gary S., Ryoo, Hyun-Mo   +13 more
core   +2 more sources

Long non-coding RNAs in bone formation: Key regulators and therapeutic prospects

Open Life Sciences
Recent scientific investigations have revealed the intricate mechanisms underlying bone formation, emphasizing the essential role of long non-coding RNAs (lncRNAs) as critical regulators.
Jiang Chun, Wang Peng, Tan ZhenWei, Zhang Yin   +3 more
doaj   +1 more source

Force‐Electric Nanotentacles of Tantalum Implant Accelerate Cellular Energy Metabolism/Crosstalk for Immunomodulation‐Vascularized Bone Integration

Advanced Science, EarlyView.
A biomimetic force‐electric nanotentacle‐enabled tantalum (Ta) implant with surface‐nanostructured LiTaO3 (n‐LiTaO3) was first developed via laser nanofabrication combined with Li+‐induced in situ reaction, enabling the transduction of ultrasound into bioelectrical cues.
Taixing Zhang, Ke Ma, Kangqing Zuo, Pandong Lin, Tailong Zhang, Rongliang Ding, Linbo Zhang, Aonan Li, Yinchuan Wang, Yanling Huang, Jichao Feng, Guiyong Xiao, Yupeng Lu, Bing Han, Zhiqiang Wang, Ningbo Li   +15 more
wiley   +1 more source