Results 101 to 110 of about 69,808 (343)

Specific Residues of RUNX2 Are Obligatory for Formation of BMP2-Induced RUNX2-SMAD Complex to Promote Osteoblast Differentiation

, 2008
BMP2 signaling and RUNX2 regulatory pathways converge for transcriptional control of bone formation in vivo. SMAD proteins are recruited to RUNX2 regulatory complexes via an overlapping nuclear matrix targeting signal/Smad interacting domain sequence ...
Pratap, Jitesh, Janet L. Stein, Gary S. Stein, Soraya Gutierrez, Stein, Janet L., Javed, Amjad, Faiza Afzal, Van Wijnen, Andre J., Andre J. van Wijnen, Jong-Sup Bae, Jitesh Pratap, Lian, Jane B., Gutierrez, Soraya E., Amjad Javed, Kaleem Zaidi, Bae, Jong-Sup, Jane B. Lian, Afzal, Faiza, Zaidi, Kaleem, Stein, Gary S.   +19 more
core   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

C/EBPβ binds the P1 promoter of the Runx2 gene and up‐regulates Runx2 transcription in osteoblastic cells [PDF]

Journal of Cellular Physiology, 2011
AbstractThe Runx2 factor is an essential component of the regulatory mechanisms that control transcription during skeletogenesis. Runx2/p57 expression in osteoblastic cells is controlled by the P1 promoter, which is recognized by key regulators of osteoblast differentiation including homeodomain factors and Wnt‐ and BMP‐signaling mediators.
Henriquez, B., Hepp, M., Merino, P., Sepúlveda, H., Van Wijnen, A.J., Lian, J.B., Stein, J.L., Stein, G.S., Montecino, M.   +8 more
openaire   +7 more sources

Transcriptional Programming in Arteriosclerotic Disease: A Multifaceted Function of the Runt-related Transcription Factor 2 (Runx2)

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Despite successful therapeutic strategies in the prevention and treatment of arteriosclerosis, the cardiovascular complications remain a major clinical and societal issue worldwide.
Ya-Bing Chen, Xin-Yang Zhao, Hui-Ann Wu
semanticscholar   +1 more source

Bone morphogenetic protein-2 stimulates RUNX2 acetylation

, 2006
Runx2/Cbfa1/Pebp2aA is a global regulator of osteogenesis and is crucial for regulating the expression of bone-specific genes. Runx2 is a major target of the bone morphogenetic protein (BMP) pathway.
Norikazu Nishino, Je-Yong Choi, Jin, Yun-Hye, Eun-Joo Jeon, Byung-Chul Oh, Nishino, Norikazu, Lee, Kyeong-Sook, Hyun-Mo Ryoo, Minoru Yoshida, Mi-Hye Lee, Choi, Je-Yong, Hyun-Nam Kim, Choi, Nam-Sook, Kyeong-Sook Lee, Yun-Hye Jin, Jeon, Eun-Joo, Yong Hee Lee, Lee, Kwang-Youl, Kim, Hyun-Nam, Lee, Yong Hee, Yoshida, Minoru, Bae, Suk-Chul, Nam-Sook Choi, Suk-Chul Bae, Kwang-Youl Lee, Lee, Mi-Hye, Oh, Byung-Chul, Ryoo, Hyun-Mo   +27 more
core   +1 more source

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

Advanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang, Pan Liu, Jie Lei, Shuchang Peng, Qiu Chen, Wei Guan, Yizhou Zhu, Gang Liu, Xiaobo Feng, Cao Yang, Lei Tan   +10 more
wiley   +1 more source

SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2. [PDF]

PLoS ONE, 2017
Activation of SIRT1 has previously been shown to protect mice against osteoporosis through yet ill-defined mechanisms. In this study, we outline a role for SIRT1 as a positive regulator of the master osteoblast transcription factor, RUNX2.
Kayvan Zainabadi, Cassie J Liu, Leonard Guarente   +2 more
doaj   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source