Results 121 to 130 of about 69,808 (343)
Cancer Management and Research, 2020 Yonghai Guan,1,* Ying Zhang,2,* Lina Hao,3 Zhenwang Nie1 1Department of Infectious Diseases, The Second Hospital of Dalian Medical University, Dalian 116023, Liaoning, People’s Republic of China; 2Sixth Department of Liver Diseases, The Sixth ...
Guan Y, Zhang Y, Hao L, Nie Z
doaj
Journal of Experimental & Clinical Cancer Research, 2019 Background RUNX2 is a Runt-related transcription factor required during embryogenesis for skeletal development and morphogenesis of other organs including thyroid and breast gland.
Gloria Manzotti +5 more
doaj +1 more source
RUNX2 and CBFB co-occupy many loci in the genome.
, 2016 (A) Genomic views of RUNX2 and CBFB binding on the SP7 and ALPL loci. Black bars underneath genomic view are identified peaks by the MACS algorithm. (B) Venn diagram of the numbers of RUNX2 peaks and CBFB peaks.
Eryney Marrogi (2541376) +8 more
core +1 more source
Advanced Science, EarlyView.This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li +12 more
wiley +1 more source
Oro-dental phenotype in patients with RUNX2 duplication
, 2018 International audienceRunt-related transcription factor 2 (RUNX2) is well-known for its role in bone development and tooth mor-phogenesis. Most RUNX2 mutations described in the literature result in loss-of-function mutations of RUNX2 responsible for ...
Tony Prud’Homme +9 more
core +1 more source
Advanced Science, EarlyView.Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai +12 more
wiley +1 more source
VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcription
Science Advances, 2020 VGLL4 relieves TEADs-mediated RUNX2 transcriptional inhibition by impairing TEADs-RUNX2 interaction. VGLL4 has been identified as a YAP inhibitor. However, the exact function of VGLL4 in bone development and bone homeostasis remains unclear.
Jinlong Suo +6 more
semanticscholar +1 more source
TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma
Advanced Science, EarlyView.TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin +9 more
wiley +1 more source
Runx2+ Niche Cells Maintain Incisor Mesenchymal Tissue Homeostasis through IGF Signaling
Cell Reports, 2020 SUMMARY Stem cell niches provide a microenvironment to support the self-renewal and multi-lineage differentiation of stem cells. Cell-cell interactions within the niche are essential for maintaining tissue homeostasis. However, the niche cells supporting
Shuo Chen +8 more
semanticscholar +1 more source
Advanced Science, EarlyView.Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu +5 more
wiley +1 more source