Results 141 to 150 of about 69,808 (343)
DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes
Scientific Reports, 2017 The Runt-related transcription factor 2 (RUNX2) is critical for bone formation as well as chondrocyte maturation. Matrix metalloproteinase (MMP)-13 is a major contributor to cartilage degradation in osteoarthritis (OA).
Atsushi Takahashi +6 more
doaj +1 more source
Advanced Science, EarlyView.Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng +16 more
wiley +1 more source
TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts.
PLoS ONE, 2011 Deletion of TIEG1/KLF10 in mice results in a gender specific osteopenic skeletal phenotype with significant defects in both cortical and trabecular bone, which are observed only in female animals.
John R Hawse +10 more
doaj +1 more source
American Journal of Men's Health, 2020 Runt-related transcription factor 2 (RUNX2) plays a pivotal role in the pathogenesis of pulmonary arterial hypertension (PAH); yet, whether circulating levels of RUNX2 can predict survival of patients with idiopathic PAH (IPAH) is still unclear.
Xuntao Yuan MD +7 more
doaj +1 more source
Advanced Science, EarlyView.An assembly porous titanium/β‐TCP implant is developed to establish a spatially programmable osteogenic microenvironment for enhanced osseointegration. By decoupling mechanical support from bioactive ion release, localized ionic gradients generated from the β‐TCP module direct osteogenic activity and bone ingrowth toward the porous titanium framework ...
Heng Zhang +5 more
wiley +1 more source
Analysis of RUNX2 expression in SKOV3 cells.
, 2013 A. Semi-quantitative duplex RT-PCR analysis of RUNX2 mRNA expression levels in the shRNA-RUNX2 clones 3 and 6, compared to the mock-transfected control clone. Displayed are images of representative results following sqRT-PCR analysis.
Stephane Gobeil (108928) +10 more
core +1 more source
Advanced Science, EarlyView.RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan +8 more
wiley +1 more source
Branch site mutated mice revealed distinct roles of two Runx2 isoforms in bone development
Frontiers in Cell and Developmental BiologyRunx2 is a key regulator of osteoblast differentiation and chondrocyte maturation. However, the distinct functions of the two functional isoforms remain to be clarified.
Qing Jiang +12 more
doaj +1 more source
Runx2 plays a central role in Osteoarthritis development
Journal of Orthopaedic Translation, 2019 Osteoarthritis (OA) is the most common form of arthritis, is the leading cause of impaired mobility in the elderly, and accounts for more than a third of chronic moderate to severe pain.
Di Chen +4 more
semanticscholar +1 more source
RUNX2 associated long non-coding RNA characterization [PDF]
, 2018 RUNX2 is a lineage-specific transcription factor (TF) known to promote cancer progression. However, the molecular mechanisms that control RUNX2 expression in cancer remain widely unknown.
Rossi, Teresa
core