Results 151 to 160 of about 52,415 (197)
Functionalizing biomaterials for osseointegration - microRNAs at the crossroads of bone formation and immune modulation. [PDF]
Bone Joint ResAzari M, Della Bella E, Wildemann B.
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International Journal of Molecular Sciences, 2023 Runt-related transcription factor 2 (RUNX2) is critical for the modulation of chondrocyte osteoblast differentiation and hypertrophy. Recently discovered RUNX2 somatic mutations, expressional signatures of RUNX2 in normal tissues and tumors, and the ...
Tsung-Chieh Lin
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The expression of Runx2 in the pathogenesis of periodontitis
Oral Diseases, 2023Abstract Objective Runt‐related transcription factor 2 (Runx2) plays an important role in bone metabolism; however, the relationship between Runx2 and periodontitis remains unclear. We investigated Runx2 expression in the gingiva of patients to explore its role in periodontitis.
Miaomiao Wang +6 more
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Anti-Cancer Agents in Medicinal Chemistry, 2015
Osteosarcoma (OS) is the most common pediatric bone cancer in children and young adults. Previous studies have suggested the importance of osteoblast activity in OS tumorigenesis and metastasis, as OS is characterized by abnormal bone formation, while osteoblast is the predominant cell type both in OS and in metastatic tumor tissues.
Na, Li +9 more
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Osteosarcoma (OS) is the most common pediatric bone cancer in children and young adults. Previous studies have suggested the importance of osteoblast activity in OS tumorigenesis and metastasis, as OS is characterized by abnormal bone formation, while osteoblast is the predominant cell type both in OS and in metastatic tumor tissues.
Na, Li +9 more
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Control of Tooth Morphogenesis by Runx2
Critical Reviews™ in Eukaryotic Gene Expression, 2006Odontogenesis is a complex process in which the interplay of signaling cascades of the epithelium and mesenchyme is critical. Evidence for the involvement of Runx2--a well-known osteogenic master transcription factor--in odontogenesis, has been accumulating.
Hyun-Mo, Ryoo, Xiu-Ping, Wang
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Transcriptional co-repressors of Runx2
Journal of Cellular Biochemistry, 2006Runx2 is an essential transcription factor for skeletal mineralization because it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy, and contributes to endothelial cell migration and vascular invasion of developing bones.
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Biology of RUNX2 and Cleidocranial Dysplasia
Journal of Craniofacial Surgery, 2013Three features of cleidocranial dysplasia that are not always appreciated are hypoplastic iliac wings, short stature, and brachydactyly. Because of the pelvic abnormality, pregnant women may require a cesarean delivery. Short stature and brachydactyly indicate more generalized skeletal abnormalities.
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Regulation of Runx2 by MicroRNAs in osteoblast differentiation
Life Sciences, 2019Bone is one of the most dynamic organs in the body that continuously undergoes remodeling through bone formation and resorption. A cascade of molecules and pathways results in the osteoblast differentiation that is attributed to osteogenesis, or bone formation. The process of osteogenesis is achieved through participation of the Wnt pathway, FGFs, BMPs/
Nagarajan Selvamurugan, M Rohini
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Immunolocalization and Expression of Runx2 in Tertiary Dentinogenesis
Hybridoma, 2010Runx2 is a new transcription factor that takes part in odontoblast differentiation. This study is aimed at investigating the immunolocalization and expression of Runx2 in the process of dental pulp injury and repair using immunohistochemical technique. In normal dental pulp, positive staining can hardly be detected.
Jun, Wen +4 more
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