Results 131 to 140 of about 69,808 (343)

RANKL, OPG, and RUNX2 expression and epigenetic modifications in giant cell tumour of bone in 32 patients: association with clinicopathological characteristics and recurrence

Bone & Joint Research
Aims: The present study investigated receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG), and Runt-related transcription factor 2 (RUNX2) gene expressions in giant cell tumour of bone (GCTB) patients in relationship with ...
Raja Amri, Ameni Chelly, Mariem Ayedi, Mohammed A. Rebaii, Sami Aifa, Sabeur Masmoudi, Hassib Keskes   +6 more
doaj   +1 more source

Role of the RUNX2 p.R225Q mutation in cleidocranial dysplasia: a rare presentation and an analysis of the RUNX2 protein structure

Genetics and Molecular Research, 2014
Cleidocranial dysplasia (CCD; MIM 119600) is an autosomal dominant hereditary disorder of skeletal features whose characteristic clinical symptoms are caused by mutations in the RUNX2 gene. Varying degrees of clavicular hypoplasia and dental abnormalities are the most prominent features of this disorder.
L Z, Wu, W Q, Su, Y F, Liu, X, Ge, Y, Zhang, X J, Wang   +5 more
openaire   +2 more sources

Association of functionally different RUNX2 P2 promoter alleles with BMD

, 2006
RUNX2 gene SNPs were genotyped in subjects from the upper and lower deciles of age- and weight-adjusted femoral neck BMD. Of 16 SNPs in RUNX2 and its two promoters (P1 and P2), only SNPs in the P2 promoter were significantly associated with BMD. These P2
van Daal, Angela, Day, Christopher, Day, Christopher J., Stephens, Alexandre, Morrison, NA, Carter, SL, Nicholson, Geoff, van Daal, A, Carter, Shea, Kotowicz, MA, Carter, Shea L., Doecke, James D., Kotowicz, Mark A., Nicholson, GC, Stephens, Alexandre S. J., Morrison, Nigel, Morrison, Nigel A., Stephens, ASJ, Nicholson, Geoffrey C., Doecke, James, Kotowicz, Mark, Doecke, JD, Day, CJ   +22 more
core   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

RUNX2 Plays An Oncogenic Role in Esophageal Carcinoma by Activating the PI3K/AKT and ERK Signaling Pathways

Cellular Physiology and Biochemistry, 2018
Background/Aims: Esophageal carcinoma is a frequently occurring cancer at upper gastrointestinal tract. We aimed to evaluate the roles and possible mechanism of Runt Related Transcription Factor 2 (RUNX2) in the development of esophageal cancer. Methods:
Huibin Lu, Tian Jiang, Kewei Ren, Zongming Li Li, Jianzhuang Ren, Gang Wu, Xinwei Han   +6 more
doaj   +1 more source

NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2 [PDF]

, 2014
Runt-related transcription factor 2 (Runx2) transactivates many genes required for osteoblast differentiation. The role of N-alpha-acetyltransferase 10 (NAA10, arrest-defective-1), originally identified in yeast, remains poorly understood in mammals ...
Yoon, Haejin, Shin, Dong Hoon, Park, Jong-Wan, Lee, Dong Yeon, Lee, Kyoung-Hwa, Kim, Hye-Lim, Lee, Zang Hee, Lee, Mi-Ni, Kim, Hong-Hee, Oh, Goo Taeg, Chun, Yang-Sook, Ryoo, Hyun-Mo, Shin, Chan Soo, 이미니, 오구택   +14 more
core   +1 more source

An Injectable and Self‐Reinforced Piezoelectric Hydrogel for Irregular Bone Defects Regeneration: Dynamic Epigenetic Regulation Approach

Advanced Science, EarlyView.
An injectable and self‐reinforcing RSF‐based piezoelectric hydrogel conforms to irregular bone defects and progressively strengthens in situ, overcoming the trade‐off between injectability and mechanical stability. Mechanical loading generates bioelectrical cues that promote P300‐mediated H3K9 acetylation and upregulate PTH1R expression, thereby ...
Yu‐Kai Huang, Juan Li, Miao‐Miao Yang, Chao Jia, Quan‐Xin Gong, Guang‐Cheng Yuan, Dong Zhou, Wen‐Hui Shen, Zeng‐Gan Chen, Zhi‐Rui Dong, Jin‐Wang Huang, Jie Peng, Di‐Han Su, Ming‐Dong Zhao, Jian Dong, Li‐Bo Jiang   +15 more
wiley   +1 more source

Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells

Molecular Cancer, 2012
Background The Runt-related transcription factor Runx2 is essential for bone development but is also implicated in progression of several cancers of breast, prostate and bone, where it activates cancer-related genes and promotes invasive properties.
Tandon Manish, Gokul Karthiga, Ali Syed A, Chen Zujian, Lian Jane, Stein Gary S, Pratap Jitesh   +6 more
doaj   +1 more source

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2-KLF4. [PDF]

Cell Prolif
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Zeng W, Lin Y, Gao Y, Huang D, Li Y, Ruan H, Yuan G, Liu H, Chen Z.   +8 more
europepmc   +2 more sources

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source