Results 161 to 170 of about 69,808 (343)

Analysis of the transcription Factor RUNX2, especially the RUNX2-Cbfß interaction in the pathogenesis of cleidocranial dysplasia

, 2006
RUNX2, auch als CBFA1, OSF2 und AML-3 bezeichnet, ist ein für die Knochenentwicklung essentieller Transkriptionsfaktor. Mäuse, die einen homozygoten Defekt des RUNX2 Gens aufweisen (Runx-/-), zeigen einen vollständigen Block in der ...
Schäfer, Henning Sebastian
core  

Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+‐CaMKK2‐AMPK Signaling to Counter MASLD

Advanced Science, EarlyView.
In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong‐Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang   +18 more
wiley   +1 more source

RUNX2 isoform II protects cancer cells from ferroptosis and apoptosis by promoting PRDX2 expression in oral squamous cell carcinoma

eLife
Ferroptosis is a distinct iron-dependent programmed cell death and plays important roles in tumor suppression. However, the regulatory mechanisms of ferroptosis need further exploration. RUNT-related transcription factor 2 (RUNX2), a transcription factor,
Junjun Huang, Rong Jia, Jihua Guo
doaj   +1 more source

The prolyl hydroxylase inhibitor dimethyloxalylglycine enhances dentin sialophoshoprotein expression through VEGF-induced Runx2 stabilization.

PLoS ONE, 2014
Prolyl hydroxylase (PHD) inhibitors are suggested as therapeutic agents for tissue regeneration based on their ability to induce pro-angiogenic responses.
Saeed Ur Rahman, Min-Sun Lee, Jeong-Hwa Baek, Hyun-Mo Ryoo, Kyung Mi Woo   +4 more
doaj   +1 more source

Hepatocyte growth factor-induced BMP-2 expression is mediated by c-Met receptor, FAK, JNK, Runx2, and p300 pathways in human osteoblasts

, 2012
[[abstract]]Hepatocyte growth factor (HGF) has been demonstrated to stimulate osteoblast proliferation and participated bone remodeling. Bone morphogenetic protein-2 (BMP-2) is a crucial mediator in bone formation during fracture healing.
黃元勵;Huang, Yuan-Li
core  

C/EBPbeta binds the P1 promoter of the Runx2 gene and up-regulates Runx2 transcription in osteoblastic cells

, 2011
The Runx2 factor is an essential component of the regulatory mechanisms that control transcription during skeletogenesis. Runx2/p57 expression in osteoblastic cells is controlled by the P1 promoter, which is recognized by key regulators of osteoblast ...
Lian, Jane B., Montecino, Martin A., Stein, Janet L., Henriquez, Berta, Hepp, Matias, Van Wijnen, Andre J., Merino, Paola, Stein, Gary S.   +7 more
core   +1 more source

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source

Expression of Sox6, Runx2, and Rcan3 in inflamed joints.

, 2013
Representative histological features of the tibiotalar joints of saline-treated CIA mice and GSPE-treated mice. Immunohistochemical staining for Sox6, Runx2, and Rcan3 is shown.
Jin-Sil Park (294905), Mi-Ae Lim (294918), Ho-Youn Kim (26636), Ji Hyeon Ju (294921), Zang Hee Lee (294927), Mi-La Cho (46882), Hye-Joa Oh (294912), Jong-Ho Lee (89784), Jun-Ki Min (46887), Yun-Ju Woo (294915), Sung-Hwan Park (26633), Mi-Kyung Park (56053), Young Ok Jung (294924)   +12 more
core   +1 more source

A Programmable Braided Silk‐Glass Fiber Ligament Promoting Rapid Motoric Recovery

Advanced Science, EarlyView.
A scalable three‐dimensional braiding strategy integrates silk and glass fibers into customizable artificial ligaments with programmable “J‐shaped” nonlinear mechanics. The silk‐rich architecture supports osseoligamentous integration, while glass fibers provide mechanical reinforcement and biomimetic mineralization cues, enabling strain‐adaptive load ...
Changbo Lu, Daming Liu, Haoxin Zhang, Zhiwei Qiao, Qiuming Gao, Jia Meng, Hongyin Yue, Songkai Li, Shuo Zhang, Tao Yuan, Yun Xue, Hui Jiang, Zhenguo Liu, Yibo Wang, Nirong Bao, Yuli Chen, Xiaojiang Yang   +16 more
wiley   +1 more source

Intracellular Delivery of Recombinant RUNX2 Facilitated by Cell-Penetrating Protein for the Osteogenic Differentiation of hMSCs

, 2020
Human mesenchymal stem cells (hMSCs) are a commonly used cell source for cell therapy and tissue engineering because of their easy accessibility and multipotency.
Jina Ryu, Seung Hyun L. Kim, Lee, Haein, Yoon, Hyungro, Hyungro Yoon, Nathaniel S. Hwang, Hwang, Nathaniel S., Park, Tai Hyun, Haein Lee, Hee Ho Park, Tai Hyun Park, Park, Hee Ho, Kim, Seung Hyun L., Ryu, Jina   +13 more
core   +1 more source