Results 181 to 190 of about 41,144 (263)

Ovine bone graft enhances osteogenic commitment in human osteoblasts via selective suppression of miR-6797-5p: In silico and in vitro study. [PDF]

J Oral Biol Craniofac Res
Sethi A, Shah KK, Ganapathy D, Abullais SS, Almuaddi A, Sekaran S.   +5 more
europepmc   +1 more source

Species‐specific roles of cellular communication network proteins in cartilage development: A comparative study using in vitro chondrogenic models

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Cross‐species network analysis identifies CCN1/2 as conserved hubs linking extracellular matrix assembly, growth factor signaling, and mechanosensitive pathways during chondrogenesis, guiding model selection and informing CCN‐targeted cartilage regeneration strategies.
Zhangzheng Wang, Judit Vágó, Roland Takács, Szilárd Póliska, Ee Hyun Kim, Eun‐Jung Jin, Satoshi Kubota, Celina G Kleer, Bernard Perbal, Csaba Matta   +9 more
wiley   +1 more source

High‐Content Immunofluorescence Quantification of Transcription Factors: Application to pSMADs for BMP/TGFβ Signaling Pathways

Current Protocols, Volume 6, Issue 6, June 2026.
Abstract High‐throughput immunofluorescence (IF) detection has become an essential tool in drug discovery for analyzing multiple markers and providing insights into cellular pathways. While IF techniques have been established for decades, high‐content IF protocols vary among laboratories, highlighting the need for standardized and quantitative ...
Valia Khodr, Paul Machillot, Catherine Picart   +2 more
wiley   +1 more source

The Role of MicroRNA in the Behaviour of Periodontal Ligament Stem Cells and Stem Cells from the Apical Papilla: A Systematic Review. [PDF]

Stem Cell Rev Rep
Sanz JL, Forner L, López-García S, Rodríguez-Lozano FJ, Santos JM, Folguera S, López-Ginés C, Monleón D.   +7 more
europepmc   +1 more source

VSMC phenotypic switching in thoracic aortic aneurysm at single‐cell resolution: Trajectories, regulatory circuits, and spatial niches

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
•Single‐cell/spatial multi‐omics identify four VSMC phenotypic states in TAA progression. •KLF4 as master hub (TGF‐β/TNF‐α/mechanical stress) orchestrating chromatin remodelling. •Pseudotime trajectories mapping contractile phenotypes towards osteogenic (RUNX2/SOX9) and inflammatory (TNF‐α/IL‐6) fates within spatial medial niches. •cfDNA biomarkers and
Zehua Shao, Chunguang Guo, Zhongyuan Lu, Jianyang Liu, Hao Tang, Hongwei Guo, Zhidong Zhang   +6 more
wiley   +1 more source

miR-199a-3p Promotes Adipogenic Differentiation to Aggravate Steroid-Induced Osteonecrosis of Femoral Head via the ITGB8/FAK-ERK/RUNX2 Pathway. [PDF]

Research (Wash D C)
Yang W, Yang Y, Nie M, Bai H, Zhang H, Zhang J.   +5 more
europepmc   +1 more source

NAT10‐mediated N4‐acetylcytidine modification drives RNA splicing of PML to alleviate adipose‐derived stem cell senescence and promote diabetic wound healing

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
N‐acetyltransferase 10 (NAT10) catalyses N4‐acetylcytidine (ac4C) modification of PML pre‐mRNA, shifting splicing from the senescence‐promoting PML‐FL to the senescence‐inhibiting PML‐S isoform via SRSF1. This rejuvenates adipose‐derived stem cells (ADSCs) by reducing senescence markers and senescence‐associated secretory phenotype (SASP), thereby ...
Wuhan Wei, Chanyuan Jiang, Dong Zhu, Xuefeng Han, Xuan Ma, Xinyu Jia, Jiaqi Ling, Rui Zhang, Facheng Li, Ningbei Yin   +9 more
wiley   +1 more source

Semaglutide Inhibits Osteoblast Ferroptosis Induced by Diabetic Periodontitis via Modulating the Wnt5a/Ror2/p38 MAPK Signaling Pathway. [PDF]

Drug Des Devel Ther
Zhang Z, Niu D, Qiu W, Feng H, Jia L, Zhou W.   +5 more
europepmc   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source