Results 31 to 40 of about 807,608 (297)

Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4 [PDF]

Endocrinology and Metabolism, 2016
Vascular calcification, abnormal mineralization of the vessel wall, is frequently associated with aging, atherosclerosis, diabetes mellitus, and chronic kidney disease.
Jaechan Leem, In-Kyu Lee
doaj   +1 more source

Prothrombin Loading of Vascular Smooth Muscle Cell-Derived Exosomes Regulates Coagulation and Calcification [PDF]

, 2016
Objective-The drug warfarin blocks carboxylation of vitamin K-dependent proteins and acts as an anticoagulant and an accelerant of vascular calcification.
Kapustin, Alexander, Schoppet, Michael, Hackeng, Tilman M.; id_orcid, Schurgers, Leon, Schurgers, Leon J.; id_orcid, Hackeng, Tilman M., Schlieper, Georg, Reynolds, Joanne L., Schoppel, Michael, Shanahan, Catherine M., Reynolds, Joanne, Kapustin, Alexander N., Harrison, Paul; id_orcid, Jahnen-Dechent, Willi, Harrison, Paul, Schurgers, Leon J., Shanahan, Catherine, Hackeng, Tilman, McNair, Rosamund, Heiss, Alexander   +19 more
core   +2 more sources

Influence of FOSL1 Inhibition on Vascular Calcification and ROS Generation through Ferroptosis via P53-SLC7A11 Axis

Biomedicines, 2023
Background: Vascular calcification during aging is highly prevalent in patients with cardiovascular disease; however, there is still no improvement in clarifying the development of vascular calcification.
Sisi Shao, Yaoxin Liu, Wanzi Hong, Yuanxi Mo, Fen Shu, Lei Jiang, Ning Tan   +6 more
doaj   +1 more source

Vitamin K and vascular calcification [PDF]

, 2021
Purpose of review Vascular calcification is a common and important cardiovascular risk factor in patients with chronic kidney disease (CKD). Recent advances in the understanding of the biology of vascular calcification implicate vitamin K-dependent ...
Mark, Patrick B., Witham, Miles D., Jennifer S. Lees, Patrick B. Mark, Miles D. Witham, Lees, Jennifer S.   +5 more
core   +1 more source

Impact of vascular calcification on cardiovascular mortality in hemodialysis patients: clinical significance, mechanisms and possible strategies for treatment

Renal Replacement Therapy, 2017
Vascular calcification has now been recognized as a major problem in dialysis patients because of its strong influence on the prognosis. Along with the regulatory failure of calcification-inhibitory system, active phenotypic change of vascular smooth ...
Takayasu Ohtake, Shuzo Kobayashi
doaj   +1 more source

Lessons learnt from progressive vascular calcification in a renal transplant recipient

Indian Journal of Transplantation, 2022
Chronic kidney disease − mineral bone disorder is a common complication in patients with renal failure. Vascular calcification is the part of this clinical syndrome and progresses over the years.
Urmila Anandh, Ritesh Kumar, G Ramesh
doaj   +1 more source

Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification [PDF]

, 2020
Rationale: Vascular calcification, the formation of calcium phosphate crystals in the vessel wall, is mediated by vascular smooth muscle cells (VSMCs).
Catherine Shanahan, Asim Akbulut, van Gorp, Rick, Rick van Gorp, Schurgers, Leon, Brecht Willems, Guillaume van Eys, Diane Proudfoot, Furmanik, Malgorzata, Akbulut, Asim, Perisic, Ljubica, Bochaton-Piallat, Marie Luce, Ulf Hedin, Proudfoot, Diane, Biessen, Erik, Erik Biessen, Marie-Luce Bochaton-Piallat, Chatrou, Martijn, Martijn Chatrou, Shanahan, Catherine; id_orcid, Leon Schurgers, van Eys, Guillaume, Harald Schmidt, Mees, Barend, Willems, Brecht, Reutelingsperger, Chris, Chris Reutelingsperger, Biessen, Erik; id_orcid, Barend Mees, Schmidt, Harald, Hedin, Ulf, Schurgers, Leon; id_orcid, Bochaton-Piallat, Marie-Luce, Malgorzata Furmanik, Ljubica Perisic, Shanahan, Catherine   +35 more
core   +2 more sources

The role of sacubitril/valsartan in abnormal renal function patients combined with heart failure: a meta-analysis and systematic analysis

Renal Failure
Aims This study aimed to investigate the efficacy and safety of sacubitril/valsartan in abnormal renal function (eGFR < 60 ml/min/1.73m2) patients combined with heart failure based on randomized controlled trials (RCTs) and observational studies.Methods ...
Xinyue Yang, Jingjing Jin, Meijuan Cheng, Jinsheng Xu, Yaling Bai   +4 more
doaj   +1 more source

Calcification of Synthetic Vascular Grafts: A Systematic Review

EJVES Vascular Forum, 2023
Objective: Calcification of vascular grafts, including polyethylene terephthalate (PET) and expanded polytetrafluoroethylene (ePTFE) grafts may contribute to graft failure, but is under reported.
Anne Lejay, Bogdan Bratu, Salomé Kuntz, Nicole Neumann, Frederic Heim, Nabil Chakfé   +5 more
doaj   +1 more source

Genetics of Vascular Calcification [PDF]

Circulation Research, 2011
### NT5E Mutations and Arterial Calcifications Hilaire et al NEJM. 2011;364:432–442. Recessive mutations in the NTE5 gene were recently described in lower-extremity vascular calcification. ENPP1 mutations were previously described in a severe disorder of vascular calcification in infancy.
openaire   +2 more sources