Results 11 to 20 of about 143,500 (200)

HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype. [PDF]

Nature Genetics, 2019
Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending ...
Bagchi, Aranya, Barnes, Hanna J, Bloch, Donald B, Bowden, Donald W, Budoff, Matthew, Buswell, Mary D, Buys, Emmanuel S, Campbell, Catherine Y, Criqui, Michael H, Debette, Stephanie, Erbel, Raimund, Feitosa, Mary F, Franceschini, Nora, Freedman, Barry I, Gudnason, Vilmundur, Guo, Xiuqing, Harris, Tamara, Hoffmann, Udo, Hwang, Shih-Jen, Johnson, Andrew D, Jöckel, Karl-Heinz, Kälsch, Hagen, Lindsay, Mark E, Lino Cardenas, Christian L, Lu, Lingyi, Malhotra, Rajeev, Mauer, Andreas C, Moebus, Susanne, Nicholson, Christopher J, Nigwekar, Sagar U, Nöthen, Markus M, O'Donnell, Christopher J, Pechlivanis, Sonali, Post, Wendy S, Rhee, David K, Rotter, Jerome I, Rourke, Caitlin O', Shelton, Georgia, Sigurdsson, Sigurdur, Sigurslid, Haakon H, Slocum, Charles, Smith, Albert V, Song, Ci, Thanassoulis, George, Wang, Judy, Wong, Quenna, Wunderer, Florian, Yao, Jie, Zapol, Warren M, Zhang, Xiaoling   +49 more
core   +3 more sources

Vascular Calcification [PDF]

Circulation Research, 2006
Once thought to result from passive precipitation of calcium and phosphate, it now appears that vascular calcification is a consequence of tightly regulated processes that culminate in organized extracellular matrix deposition by osteoblast-like cells. These cells may be derived from stem cells (circulating or within the vessel wall) or differentiation
Rebecca C, Johnson, Jane A, Leopold, Joseph, Loscalzo   +2 more
openaire   +4 more sources

Vascular Calcification [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2004
Vascular calcification, long thought to result from passive degeneration, involves a complex, regulated process of biomineralization resembling osteogenesis. Evidence indicates that proteins controlling bone mineralization are also involved in the regulation of vascular calcification.
Moeen, Abedin, Yin, Tintut, Linda L, Demer   +2 more
openaire   +4 more sources

Pathophysiology and Clinical Impacts of Chronic Kidney Disease on Coronary Artery Calcification

Journal of Cardiovascular Development and Disease, 2023
The global prevalence of chronic kidney disease (CKD) has increased in recent years. Adverse cardiovascular events have become the main cause of life-threatening events in patients with CKD, and vascular calcification is a risk factor for cardiovascular ...
Zhuoming Dai, Xiangyu Zhang
doaj   +1 more source

The Contribution of Extracellular Vesicles From Senescent Endothelial and Vascular Smooth Muscle Cells to Vascular Calcification

Frontiers in Cardiovascular Medicine, 2022
Vascular calcification is an irreversible pathological process associated with a loss of vascular wall function. This process occurs as a result of aging and age-related diseases, such as cardiovascular and chronic kidney diseases, and leads to ...
Cristina Mas-Bargues, Cristina Mas-Bargues, Cristina Mas-Bargues, Consuelo Borrás, Consuelo Borrás, Consuelo Borrás, Matilde Alique, Matilde Alique   +7 more
doaj   +1 more source

Vascular calcification [PDF]

Journal of Renal Care, 2009
Patients with chronic kidney disease have increased cardiovascular mortality from a combination of increased atherosclerotic disease, left ventricular hypertrophy and increased prevalence of vascular calcification (VC). Previously VC was thought to be a passive process which involved the deposition of calcium and phosphate into the vessel wall. However,
Sinha, Smeeta, Eddington, Helen, Kalra, Philip A.   +2 more
openaire   +2 more sources

Vascular Calcification [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2011
More than a century ago, Monckeberg1 was among the first to note that ectopic calcification may arise in the vasculature. Although this original description was of a specific form of sclerosing calcification that largely affects the vascular medial layer, we have since gone on to appreciate that generalized vascular calcification is a pervasive and ...
Jason C, Kovacic, Gwendalyn J, Randolph
openaire   +5 more sources

Epidemiological Research Advances in Vascular Calcification in Diabetes

Journal of Diabetes Research, 2021
Vascular calcification is the transformation of arterial wall mesenchymal cells, particularly smooth muscle cells (SMCs), into osteoblast phenotypes by various pathological factors.
Haipeng Yao, Zhen Sun, Guangyao Zang, Lili Zhang, Lina Hou, Chen Shao, Zhongqun Wang   +6 more
doaj   +1 more source

Research Models for Studying Vascular Calcification [PDF]

, 2020
Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process.
Babic, Milen, Giet, Markus van der, Herrmann, Jaqueline, Schuchardt, Mirjam, Tölle, Markus   +4 more
core   +1 more source

Deletion of soluble epoxide hydrolase suppressed chronic kidney disease-related vascular calcification by restoring Sirtuin 3 expression

Cell Death and Disease, 2021
Vascular calcification is common in chronic kidney disease (CKD) and contributes to cardiovascular disease (CVD) without any effective therapies available up to date.
Wanbing He, Jieping Huang, Yang Liu, Changming Xie, Kun Zhang, Xinhong Zhu, Jie Chen, Hui Huang   +7 more
doaj   +1 more source