Role of α‐SMA, NOX4, Fibronectin, and HIF‐1α in Pulmonary Microvascular Remodeling in COPD Patients Without Pulmonary Arterial Hypertension [PDF]
The Clinical Respiratory JournalBackground Pulmonary arterial hypertension (PAH) is a severe chronic obstructive pulmonary disease (COPD) complication, with vascular remodeling occurring early in disease progression.
Guo Xiaotong +6 more
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Exosomal micro ribonucleic acid-154-5p derived from vascular smooth muscle cell mediates intracranial aneurysm phenotype in vitro via myosin light chain kinase targeting [PDF]
Journal of International Medical ResearchObjective The molecular pathogenesis of intracranial aneurysms remains undefined despite its central role in aneurysmal subarachnoid hemorrhage, a major cause of stroke and shock.
Jinhai Song +5 more
doaj +2 more sources
Role of smooth muscle progenitor cells in vascular mechanical injury and repair
Medicine in Novel Technology and Devices, 2022 Smooth muscle progenitor cells are precursor cells that express both smooth muscle cell and stem cell markers, and can differentiate into smooth muscle cells under specific condition.
Zhu-feng Dong +7 more
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Long non-coding RNAs: Modulators of phenotypic transformation in vascular smooth muscle cells
Frontiers in Cardiovascular Medicine, 2022 Long non-coding RNA (lncRNAs) are longer than 200 nucleotides and cannot encode proteins but can regulate the expression of genes through epigenetic, transcriptional, and post-transcriptional modifications.
Bing-Han Lu +16 more
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Transcription factor GATA6 promotes migration of human coronary artery smooth muscle cells in vitro
Frontiers in Physiology, 2022 Vascular smooth muscle cell plasticity plays a pivotal role in the pathophysiology of vascular diseases. Despite compelling evidence demonstrating the importance of transcription factor GATA6 in vascular smooth muscle, the functional role of GATA6 ...
Azra Alajbegovic +6 more
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Notch2 and Notch3 function together to regulate vascular smooth muscle development. [PDF]
PLoS ONE, 2012 Notch signaling has been implicated in the regulation of smooth muscle differentiation, but the precise role of Notch receptors is ill defined. Although Notch3 receptor expression is high in smooth muscle, Notch3 mutant mice are viable and display only ...
Qingqing Wang +3 more
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The role of p53 in the alternation of vascular functions
Frontiers in Pharmacology, 2022 Ageing is a risk factor for many degenerative diseases. Cardiovascular diseases (CVDs) are usually big burdens for elderly, caregivers and the health system.
Gabriel Hoi-Huen Chan +7 more
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Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function. [PDF]
PLoS ONE, 2015 Activation of the nuclear hormone receptor, PPARγ, with pharmacological agonists promotes a contractile vascular smooth muscle cell phenotype and reduces oxidative stress and cell proliferation, particularly under pathological conditions including ...
Jennifer M Kleinhenz +10 more
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Vinpocetine Attenuates the Osteoblastic Differentiation of Vascular Smooth Muscle Cells. [PDF]
PLoS ONE, 2016 Vascular calcification is an active process of osteoblastic differentiation of vascular smooth muscle cells; however, its definite mechanism remains unknown.
Yun-Yun Ma +8 more
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Cells, 2021 Among reactive oxygen species, superoxide mediates the critical vascular redox signaling, resulting in the regulation of the human cardiovascular system.
Kazumi Takaishi +3 more
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