Results 11 to 20 of about 2,150,041 (199)

Vascular smooth muscle contraction in hypertension [PDF]

Cardiovascular Research, 2018
Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia, and chronic kidney disease. Pathophysiological mechanisms contributing to the development of hypertension include increased vascular resistance, determined in large part by reduced vascular diameter due to ...
Touyz, Rhian M., Alves-Lopes, Rheure, Rios, Francisco J., De Lucca Camargo, Livia, Anagnostopoulou, Aikaterini, Arner, Anders, Montezano, Augusto C.   +6 more
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EPAC in Vascular Smooth Muscle Cells [PDF]

International Journal of Molecular Sciences, 2020
Vascular smooth muscle cells (VSMCs) are major components of blood vessels. They regulate physiological functions, such as vascular tone and blood flow. Under pathological conditions, VSMCs undergo a remodeling process known as phenotypic switching. During this process, VSMCs lose their contractility and acquire a synthetic phenotype, where they over ...
Nadine Wehbe, Suzanne Awni Nasser, Yusra Al-Dhaheri, Rabah Iratni, Alessandra Bitto, Ahmed F. El-Yazbi, Adnan Badran, Firas Kobeissy, Elias Baydoun, Ali H. Eid   +9 more
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Protein changes associated with embryonic stem cell differentiation to vascular smooth muscle cells [PDF]

, 2006
PhDEmbryonic stem (ES) cells can differentiate into many different cell lines, including vascular smooth muscle cells (SMCs). The aim of this project is to characterize protein changes during this differentiation process.
Yin, Xiaoke
core   +4 more sources

Smoothelin in Vascular Smooth Muscle Cells [PDF]

Trends in Cardiovascular Medicine, 2007
Smoothelin-A and -B have only been found in fully differentiated contractile smooth muscle cells. They are increasingly used to monitor the smooth muscle cell differentiation process to a contractile or synthetic phenotype. Vascular-specific smoothelin-B is the first smooth muscle cell marker that disappears when vascular tissues are compromised, for ...
van Eys, G.J.J.M., Niessen, P.M.G., Rensen, S.S.M.   +2 more
openaire   +3 more sources

Biochemical Properties of a Bushmaster Snake Venom Serine Proteinase (LV-Ka), and Its Kinin Releasing Activity Evaluated in Rat Mesenteric Arterial Rings

Journal of Pharmacological Sciences, 2004
A serine proteinase with kallikrein-like activity (LV-Ka) has been purified to homogeneity from bushmaster snake (Lachesis muta muta) venom. Physicochemical studies indicated that LV-Ka is a single chain glycoprotein with a molecular mass (Mr) of 33 kDa ...
Maria L.D. Weinberg, Liza F. Felicori, Cynthia A. Bello, Henrique P.B. Magalhães, Alvair P. Almeida, Arinos Magalhães, Eladio F. Sanchez   +6 more
doaj   +1 more source

iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling. [PDF]

PLoS ONE, 2012
Calcium independent group VIA phospholipase A(2) (iPLA(2)β) is up-regulated in vascular smooth muscle cells in some diseases, but whether the up-regulated iPLA(2)β affects vascular morphology and blood pressure is unknown.
Lindsay E Calderon, Shu Liu, Wen Su, Zhongwen Xie, Zhenheng Guo, Wanda Eberhard, Ming C Gong   +6 more
doaj   +1 more source

Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells

Frontiers in Endocrinology, 2020
The activation of purinergic receptors by nucleotides and/or nucleosides plays an important role in the control of vascular function, including modulation of vascular smooth muscle excitability, and vascular reactivity.
Miguel Martin-Aragon Baudel, Ricardo Espinosa-Tanguma, Madeline Nieves-Cintron, Manuel F. Navedo   +3 more
doaj   +1 more source

Acute glucose influx-induced mitochondrial hyperpolarization inactivates myosin phosphatase as a novel mechanism of vascular smooth muscle contraction

Cell Death and Disease, 2021
It is well-established that long-term exposure of the vasculature to metabolic disturbances leads to abnormal vascular tone, while the physiological regulation of vascular tone upon acute metabolic challenge remains unknown.
Jie Xu, Hongyan Yang, Lu Yang, Zhen Wang, Xinghua Qin, Jiaheng Zhou, Ling Dong, Jia Li, Minsheng Zhu, Xing Zhang, Feng Gao   +10 more
doaj   +1 more source

Vascular Smooth Muscle Cells [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2016
Decades of work have shown that vascular smooth muscle cell (SMC) phenotypes are controlled by cues received from the local environment.1–3 When nestled into a cage of cross-linked collagen and elastin of its own making,4 medial SMCs exhibit a fully differentiated phenotype conferred by the transcriptional activity of myocardin and serum response ...
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Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching [PDF]

, 2012
Bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs) synthesis, reduces neointimal formation in animal models of vascular injury and recently has been shown to inhibit in-stent late loss in a placebo-controlled phase II clinical trial.
DI LAURO M. V., Maria Vittoria Di Lauro (127364), Teresa Iuvone (127378), Angelo Guglielmotti, Angelo Guglielmotti (127381), Pasquale Maffia (127384), Gianluca Grassia (127362), Cicala, C., MADDALUNO, MARCELLA, Francesco Maione, Maria Vittoria Di Lauro, Nicola Mascolo, Nicola Mascolo (127387), Maffia, P., Gianluca Grassia, Armando Ialenti, Antonio Parisi (127365), GRASSIA, GIANLUCA, Guglielmotti, A., IALENTI, ARMANDO, Grassia, G., IUVONE, TERESA, MASCOLO, NICOLA DOMENICO C. FERDINANDO, Carla Cicala (127370), Pasquale Maffia, MAIONE, FRANCESCO, Maione, F., Iuvone, T., Maddaluno, M., GUGLIELMOTTI A., Daniele De Filippis (127374), De Filippis, D., Antonio Parisi, Carla Cicala, Armando Ialenti (127390), Ialenti, A., Parisi, A., CICALA, CARLA, MAFFIA, PASQUALE, Marcella Maddaluno (127360), Marcella Maddaluno, Teresa Iuvone, PARISI A., Mascolo, N., Francesco Maione (127366), Di Lauro, M.V., Daniele De Filippis, DE FILIPPIS, DANIELE   +47 more
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