Results 51 to 60 of about 93,447 (262)
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Relationship between vascular calcification, osteoporosis and systemic inflammation
Сибирский научный медицинский журналA lot of patients with coronary heart disease often suffer from vascular calcification. In many cases it is accompanied by harmful cardiovascular events.
K. A. Nichiporuk +4 more
doaj +1 more source
Vascular Calcification: Current Genetics Underlying This Complex Phenomenon
Chinese Medical Journal, 2017 Objective: Vascular calcification is the consequence of the complex interaction between genetic, environmental, and vascular factors, which ultimately lead to the deposition of calcium in the tunica intima (atherosclerotic calcification) or tunica media (
Nonanzit Pérez-Hernández +7 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2022 Atmospheric PM2.5 exposure greatly contributes to the incidence of and mortality from cardiovascular disease (CVD). Owing to the crucial role of vascular calcification in the progression of CVD, it is imperative to elucidate the effects of PM2.5 on ...
Ruijun Su +5 more
doaj +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
The chemistry of thiosulfate and vascular calcification [PDF]
Nephrology Dialysis Transplantation, 2011 Thiosulfate has been shown to inhibit vascular calcification in uremic rats and may inhibit calcification in humans with end-stage renal disease but whether this is due to a systemic or local action is unknown. The underlying mechanism is also unclear but complexation of calcium ions has been proposed.In vitro assays were used to determine the effect ...
W Charles, O'Neill +1 more
openaire +2 more sources
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
VASCULAR CALCIFICATION: FROM INNOCENT BYSTANDER TO CULPRIT RISK FACTOR
Artery Research, 2017 Vascular calcification was regarded as an innocent bystander in cardiovascular disease. It was considered to be the passive chemical nucleation of calcium and phosphate ions on cellular debris and therefore the end-stage of atherosclerosis.
Leon J. Schurgers
doaj +1 more source
The leading edge of vascular calcification [PDF]
Trends in Cardiovascular Medicine, 2015 About two decades ago, when lipids were the focus of atherosclerosis research, calcific vasculopathy (or, more commonly, “vascular calcification”) had been dismissed as a non-biological, unregulated, degenerative phenomenon. Ironically, decades earlier, atherosclerosis itself had been dismissed in the same manner.
Demer, Linda L, Tintut, Yin
openaire +5 more sources
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source